1. Anti-infection
  2. Bacterial
  3. LED209

LED209 

Cat. No.: HY-19748 Purity: 98.87%
COA Handling Instructions

LED209 is a potent and orally active small molecule inhibitor of the bacterial receptor QseC and a potent prodrug with high selectivity for QseC. LED209 inhibits the binding of signaling molecules to QseC. LED209 has antibacterial activity.

For research use only. We do not sell to patients.

LED209 Chemical Structure

LED209 Chemical Structure

CAS No. : 245342-14-7

Size Price Stock Quantity
5 mg USD 31 In-stock
10 mg USD 50 In-stock
50 mg USD 220 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

LED209 is a potent and orally active small molecule inhibitor of the bacterial receptor QseC and a potent prodrug with high selectivity for QseC. LED209 inhibits the binding of signaling molecules to QseC. LED209 has antibacterial activity[1].

In Vitro

LED209 (5 nM, 24 h) decreases biofilm formation in EAEC O104:H4 and several multidrug-resistant clinical isolates of rUTIs[1].
LED209 (7.5-30 μM, 0-80 h) reduces L. pneumophila replication with IC50 values of 1.27 µM and 50.6 µM respectively[2].
LED209 (5 pM) inhibits the binding of signals (norepinephrine) to QseC, preventing QseC autophosphorylation and inhibiting QseC-mediated activation of virulence gene expression[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LED209 (20 mg/kg, p.o., a single dose at 30 min prior to intraperitoneal injection of S. Typhimurium) protects mice against S. Typhimurium and F. tularensis murine infections, as well as F. tularensis murine infections (administered orally to mice either 1, 3, 6, 9, or 24 h prior to infection)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

383.49

Formula

C19H17N3O2S2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC=C(NC(NC2=CC=CC=C2)=S)C=C1)(NC3=CC=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (651.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6076 mL 13.0381 mL 26.0763 mL
5 mM 0.5215 mL 2.6076 mL 5.2153 mL
10 mM 0.2608 mL 1.3038 mL 2.6076 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 98.87%

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

LED209 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
LED209
Cat. No.:
HY-19748
Quantity:
MCE Japan Authorized Agent: