Polygalaceae Extract

Tenuifoliside B, a component isolated from Polygalae Radix, inhibits potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment. Tenuifoliside B shows potential cognitive improvement and cerebral protective effects. Tenuifoliside B has potential to become an anti-AD lead compound.

Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection.

(E)-3',6-Disinapoylsucrose is an orally active, blood-brain barrier permeable neuroprotective agent that inhibits Aβ protein aggregation. (E)-3',6-Disinapoylsucrose exerts anxiolytic, anti-inflammatory and cognitive-enhancing effects. (E)-3',6-Disinapoylsucrose regulates the TrkB/BDNF signaling pathway, inhibits the expression of NF-κB p65, reduces pro-inflammatory cytokine levels, and alleviates neuronal damage. (E)-3',6-Disinapoylsucrose also enhances the functions of central 5-HT and noradrenergic systems, thereby improving spatial learning and memory abilities and reducing anxiety-like behaviors. (E)-3',6-Disinapoylsucrose can be used for the research of related diseases such as Alzheimer's disease, depression, memory impairment and anxiety disorder.

Frutinone A is a CYP1A2 inhibitor, possesses a chromonocoumarin structural scaffold. Frutinone A shows various biological activities, including antibacterial and antioxidant.

Verbascose, an alacto-oligosac-charides (GOS), has potent immunostimulatory activity. Verbascose acts as a potential natural immunomodulatory agent.

Sibiricaxanthone B is a xanthone isolated from Polygala tenuifolia.

Onjisaponin Z is a natural product isolated from Radix Polygalae.

Tenuifoliside C, isolated from polygala tenuifolia willd, significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.

Lancerin, isolated from the root bark of Cudraniu cochinchinensis, possesses anti-lipid peroxidation.

Polygalaxanthone XI, a xanthone glycoside isolated from the cortexes of Polygala tenuifolia, can be used in the study of expectorant, and tranquilizing agent.

Rhamnetin 3-O-β-D-glucopyranoside is a flavonoid, that can be isolated from the roots of Polygala sibirica L. (Polygalaceae).

4-Hydroxy-9h-xanthen-9-one is a natural product.

Sibiricose A6 is an oligosaccharide ester isolated from Polygalae Radix with potent antioxidant activity.

Polygalasaponin XXXII is an orally active cognitive enhancer. Polygalasaponin XXXII promotes the phosphorylation of ERK, CREB, Synapsin I and TrkB. Polygalasaponin XXXII enhances basal synaptic transmission. Polygalasaponin XXXII attenuates Scopolamine (HY-N0296)-induced cognitive impairment and improves hippocampus-dependent learning and memory abilities. Polygalasaponin XXXII can be used in research related to cognitive dysfunction.

3'-Hydroxy-5-methoxy-3,4-methylenedioxybiphenyl is a biphenyl compound found in Monnina obtusifolia. 3'-Hydroxy-5-methoxy-3,4-methylenedioxybiphenyl has antifungal activity.

[8]-Dehydrogingerdione is a Hydroxyphenylalkanone. [8]-Dehydrogingerdione can be isolated from the seeds of Aframomum melegueta and the rhizomes of Curcuma xanthorrhia. [8]-Dehydrogingerdione acts as an inhibitor of α-glucosidase and Tyrosinase, with an IC₅₀ value of 19.5 μM against α-glucosidase and an approximate IC₅₀ value of 100 μM against tyrosinase. [8]-Dehydrogingerdione can be used in diabetes-related research.

Polygalatenoside A is a noradrenaline reuptake inhibitor with an IC₅₀ of 30.0 μM against human noradrenaline transporter. Polygalatenoside A can be used in the research of mental disorders.

Tenuifoliose Q is an oligosaccharide ester esterified with acetic acid, benzoic acid and p-hydroxycinnamic acid, which can be isolated from the root bark of Polygala tenuifolia Willd.

Tenuifoliose S is an oligosaccharide multiester compound. Tenuifoliose S can be isolated from the Polygala tenuifolia.

Tenuifoliose W is a sugar ester found in the roots of Polygala tenuifolia Willd. Tenuifoliose W targets hydrogen peroxide-induced oxidative stress in keratinocytes. Tenuifoliose W can be used for the research of skin aging.