Pertussis Toxin
Based on 19 publication(s) in Google Scholar
Pertussis Toxin is a protein-based AB5-type exotoxin produced by the bacterium Bordetella pertussis, which causes whooping cough. Pertussis Toxin inhibits G protein-coupled receptor (GPR) signaling through Gi proteins.
For research use only. We do not sell to patients.
- CAS No.: 70323-44-3
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Pertussis Toxin
More- Signal Transduct Target Ther. 2024 Sep 26;9(1):254. [Abstract]
- Nat Cell Biol. 2024 Aug;26(8):1346-1358. [Abstract]
- Adv Funct Mater. 2025 Jun 17.
- Nat Commun. 2025 May 15;16(1):4502. [Abstract]
- Nat Commun. 2022 Oct 26;13(1):6365. [Abstract]
- Adv Sci (Weinh). 2026 Feb;13(10):e11069. [Abstract]
- Nat Chem Biol. 2026 Jan 6. [Abstract]
- Sci Adv. 2022 Sep 30;8(39):eabo4250. [Abstract]
- Pharmacol Res. 2023 May:191:106754. [Abstract]
- Int J Biol Macromol. 2023 Aug 30:247:125816. [Abstract]
- Clin Transl Med. 2022 Aug;12(8):e999. [Abstract]
- Glia. 2025 Apr 4. [Abstract]
- Int Immunopharmacol. 2025 Apr 4:154:114608. [Abstract]
- Int Immunopharmacol. 2024 Jul 12:139:112646. [Abstract]
- Int Immunopharmacol. 2024 May 10:132:111928. [Abstract]
- FASEB J. 2025 Jun 30;39(12):e70696. [Abstract]
- FASEB J. 2020 Nov;34(11):14892-14904. [Abstract]
- Mol Biol Rep. 2025 Nov 15;53(1):92. [Abstract]
- Res Sq. 2026 May 20:rs.3.rs-9499667. [Abstract]
All Endogenous Metabolite Isoforms
More
Biological Activity
Pertussis toxin is a secreted protein exotoxin and an important virulence factor produced exclusively by B. pertussis[1].
Pertussis toxin (PTX; 100 ng/ml; 12 h) completely suppresses the increase in G protein-coupled receptor kinase 2 (GRK2)-dependent migration in HeLa cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 70323-44-3
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Appearance Solid
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Color White to off-white
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (19)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system. [Abstract]2024 Sep 26;9(1):254. PMID: 39327467 -
Nat Cell Biol
Trafficking circuit of CD8+ T cells between the intestine and bone marrow governs antitumour immunity. [Abstract]2024 Aug;26(8):1346-1358. PMID: 39039181 -
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Nat Commun
TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis. [Abstract]2025 May 15;16(1):4502. PMID: 40374622 -
Nat Commun
Biased signaling due to oligomerization of the G protein-coupled platelet-activating factor receptor. [Abstract]2022 Oct 26;13(1):6365. PMID: 36289206 -
Adv Sci (Weinh)
An Automated Organotypic SCN Culture System Revealing Novel Insights into VIP Regulation of Circadian Rhythm. [Abstract]2026 Feb;13(10):e11069. PMID: 41536242 -
Nat Chem Biol
Photo-cross-linking-assisted deorphanization deciphers GPR50-L-LEN pairing in metabolism. [Abstract]2026 Jan 6. PMID: 41495223 -
Sci Adv
Regulation of autoimmune disease progression by Pik3ip1 through metabolic reprogramming in T cells and therapeutic implications. [Abstract]2022 Sep 30;8(39):eabo4250. PMID: 36179018 -
Pharmacol Res
G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation. [Abstract]2023 May:191:106754. PMID: 37019194 -
Int J Biol Macromol
NPFR regulates the synthesis and metabolism of lipids and glycogen via AMPK: Novel targets for efficient corn borer management. [Abstract]2023 Aug 30:247:125816. PMID: 37451386 -
Clin Transl Med
Iron controls T helper cell pathogenicity by promoting glucose metabolism in autoimmune myopathy. [Abstract]2022 Aug;12(8):e999. PMID: 35917405 -
Glia
Role of Cx43 and ACKR3 in Modulating Astrocytic Response and Neuronal Survival Post-Subarachnoid Hemorrhage. [Abstract]2025 Apr 4. PMID: 40183383 -
Int Immunopharmacol
Methyl 3,4-dihydrobenzoate attenuates muscle fiber necroptosis and macrophage pyroptosis by regulating oxidative stress in inflammatory myopathies. [Abstract]2025 Apr 4:154:114608. PMID: 40186902 -
Int Immunopharmacol
A novel PROTAC molecule dBET1 alleviates pathogenesis of experimental autoimmune encephalomyelitis in mice by degrading BRD4. [Abstract]2024 Jul 12:139:112646. PMID: 39002520 -
Int Immunopharmacol
2024 May 10:132:111928. PMID: 38537540 -
FASEB J
Hypoxia Exposure Promotes Th17 Cell Differentiation Through Activin A-PKM2 Axis to Exacerbate Autoimmune and Autoinflammatory Diseases. [Abstract]2025 Jun 30;39(12):e70696. PMID: 40515525 -
FASEB J
Inhibition of α1-adrenoceptor reduces TGF-β1-induced epithelial-to-mesenchymal transition and attenuates UUO-induced renal fibrosis in mice. [Abstract]2020 Nov;34(11):14892-14904. PMID: 32939891 -
Mol Biol Rep
Th2 cell-derived exosomes alleviate central nervous system inflammation and demyelination in experimental autoimmune encephalomyelitis by regulating inflammasomes to inhibit microglia activation. [Abstract]2025 Nov 15;53(1):92. PMID: 41240231 -
Res Sq
2026 May 20:rs.3.rs-9499667. PMID: 42239782
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Carbonetti NH, et al. Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools. Future Microbiol. 2010 Mar;5(3):455-69. [Content Brief]
[2]. Petronila Penela, et al. G protein-coupled receptor kinase 2 positively regulates epithelial cell migration. EMBO J. 2008 Apr 23;27(8):1206-18. [Content Brief]
[3]. Nicholas H Carbonetti, et al. Contribution of pertussis toxin to the pathogenesis of pertussis disease. Pathog Dis. 2015 Nov;73(8):ftv073. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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