Infection

Roselipin 1A inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm.

Scytalol D is a natural compound found in the strain of Scytalidium sp. 36-93.

CYP51-IN-22, the non-deuterated analog of CYP51-IN-23-d₃ (HY-174353S), is a potent and broad-spectrum CYP51 inhibitor.CYP51-IN-22 inhibits Aspergillus fumigatum with a MIC₈₀ of 1 μg/mL. CYP51-IN-22 can prevent fungal phase transformation and biofilm formation. CYP51-IN-22 exhibits anti-drug resistance activity and fungal activity, and shows excellent safety for cells and significant pharmacological activity in mice. CYP51-IN-22 can be used for the study of invasive fungal infections (IFIs).

Dapsone (Standard) is the analytical standard of Dapsone. This product is intended for research and analytical applications. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al.

Laccase-IN-6 is a laccase inhibitor with an IC₅₀ of 0.097 nM. Laccase-IN-6 exhibits broad-spectrum anti-fungal effect and can destroy the normal morphology of the fungi. Laccase-IN-6 can be used for the research of infection.

Cefiderocol (Standard) is the analytical standard of Cefiderocol (HY-17628). This product is intended for research and analytical applications. Cefiderocol (S-649266) is a siderophore cephalosporin which has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC₅₀s of 2 μg/mL or less.

NMT-IN-9 is an arylpyrrolidone-based NMT inhibitor with an IC₅₀ of 93.20 nM and a K_D of 5.57 × 10^-9 M against NMT. NMT-IN-9 exhibits broad-spectrum antifungal activity against Candida albicans, Candida glabrata, Candida tropicalis, Cryptococcus neoformans and Aspergillus fumigatus, with an MIC of 2-16 μg/mL, and retains activity against fluconazole-resistant Candida isolates, with an MIC of 8-16 μg/mL. NMT-IN-9 induces intracellular ROS accumulation, mitochondrial membrane depolarization, DNA damage, apoptosis and necrotic cell death in fungal cells, and disrupts fungal cell integrity. NMT-IN-9 can be used for studies on NMT-targeted antifungal mechanisms and fluconazole-resistant Candida infections.

Trimyristin (Standard) is the analytical standard of Trimyristin (HY-N2511). This product is intended for research and analytical applications. Trimyristin is an orally active compound. Trimyristin can be isolated from the seeds of nutmeg (Myristica fragrans). Trimyristin inhibits the activities of acetylcholinesterase (AChE), ACP and ALP, with IC₅₀ values of 0.11, 0.16 and 0.18 mM, respectively. Trimyristin exerts competitive-noncompetitive inhibition on acetylcholinesterase, uncompetitive inhibition on ACP, and competitive/noncompetitive inhibition on ALP. Trimyristin restores the downregulated acetylcholinesterase concentration in the cerebral cortex of rats exposed to sodium arsenite. Trimyristin can be used in studies related to fascioliasis and neurotoxicity.

Supradamal is a peptidyl-prolyl cis-trans isomerase (PPIase) inhibitor with an IC₅₀ of 83 nM against *Plasmodium falciparum* and an IC₅₀ of 75 nM against *Plasmodium vivax*. Supradamal inhibits the development, maturation and in vitro growth of *Plasmodium falciparum* trophozoites. Supradamal is applicable to malaria-related research.

Helvecardin A is a glycopeptidtic antibiotic. Helvecardin A has strong activity of anti-aerobic and anaerobic Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus.

Bromfenac (sodium) (Standard) is the analytical standard of Bromfenac (sodium). This product is intended for research and analytical applications. Bromfenac sodium is a potent and orally active inhibitor of COX, with IC50s of 5.56 and 7.45 nM for COX-1 and COX-2, respectively. Bromfenac sodium can be used in ocular inflammation research.

epi-D-Captopril (epi-D-SQ 14225) is a stereoisomer of Captopril (HY-B0368) and an inhibitor of metallo-β-lactamases (MBLs). The IC₅₀ values of epi-D-Captopril against NDM-1, IMP-1, and VIM-2 are 64 μM, 173 μM, and 5.5 μM, respectively. epi-D-Captopril is expected to be used in the research of diseases caused by MBLs-related drug-resistant bacterial infections.

7-Amino-4-methylcoumarin (Standard) is the analytical standard of 7-Amino-4-methylcoumarin. This product is intended for research and analytical applications. 7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.[4]

(S)-ZK824859 hydrochloride is a uPA inhibitor and anticoagulant. (S)-ZK824859 hydrochloride can be used for the research of severe acute respiratory syndrome caused by coronavirus and complications thereof .

Mupirocin (calcium hydrate) (Standard) is the analytical standard of Mupirocin (calcium hydrate). This product is intended for research and analytical applications. Mupirocin (BRL-4910A, Pseudomonic acid) calcium hydrate is an orally active antibiotic isolated from Pseudomonas fluorescens. Mupirocin calcium hydrate apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis.

1,3-Dithiane-d2 is the deuterium labeled 1,3-Dithiane (HY-W001189). 1,3-Dithiane is a protected formaldehyde anion equivalent and a sulfur-containing Maillard reaction product. 1,3-Dithiane is found in cooked beef extracts. 1,3-Dithiane is a potent mutagenic agent against S. typhimurium TA98 and TA100. 1,3-Dithiane can be used as a useful marker synthon.

Mniopetal C is a reverse transcriptase inhibitor found in Mniopetalum sp. 87256.

PPQ-581 is an anti-influenza agent with an EC₅₀ of 1 μM for preventing virus-induced cytopathic effects. PPQ-581 inhibits viral protein synthesis. PPQ-581 blocks the RNP nuclear export and cytoplasmic RNP aggregation.

Oganomycin GB is Streptomyces str. oganonensis Y-G 19Z and Oganomycin A is produced when p-hydroxycinnamate sodium salt is added to the fermentation medium. Under the action of D-amino acid oxidase, A generates glutaryl derivative, GA; A and GA were converted to B and GB by acid hydrolysis to remove sulfate esters. The effect of B on d-amino acid oxidase was also changed to GB. A and B were more stable than A and B of cemycin, and had stronger effect against Gram-positive and Gram-negative bacteria than Gram-positive bacteria. The antibacterial activity of A and B was higher than that of GA and GB.

D-Ribonolactone (Standard) is the analytical standard of D-Ribonolactone. This product is intended for research and analytical applications. D-Ribonolactone is sugar lactone and an inhibitor of β-galactosidase of Escherichia coli with a Ki of 26 mM.