Infection

Adenosine monophosphate-¹³C₁₀,¹⁵N₅ (AMP-¹³C₁₀,¹⁵N₅) is the ¹³C- and ¹⁵N-labeled Adenosine monophosphate (HY-A0181). Adenosine monophosphate is an adenosine A1 receptor agonist. Adenosine monophosphate has significant antiviral activity against HSV-1 and HSV-2. Adenosine monophosphate is a key cellular metabolite regulating energy homeostasis and signal transduction.

Antimalarial agent 60 is an antimalarial agent with an IC₅₀ of 116.2 nM against asexual blood-stage parasites of Plasmodium falciparum 3D7. Antimalarial agent 60 can be used in malaria research.

Pyrametostrobin is a strobilurin fungicide used to protect crops from fungal infection. Pyrametostrobin can be applied to research related to cucumber powdery mildew, powdery mildew, rust, downy mildew and blight.

4,5-O-Dicaffeoyl quinic acid methyl ester (compound 4), a dicaffeoylquinic acid, has potent antiviral activity against respiratory syncytial virus (RSV) with an IC₅₀ of 0.63 μg/mL and a CC₅₀ of 118.68 μg/mL.

Indole-3-thio carboxamide is an antifungal agent. Indole-3-thio carboxamide is a biotransformation product of Camalexin (HY-119502) by plant pathogenic fungi Botrytis cinerea.

Bictegravir-d₇ (GS-9883-d₇) is deuterium labeled Bictegravir. Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC₅₀ of 7.5 nM.

Antimicrobial agent-37 (compound 6a) is a potent broad-spectrum antimicrobial agent that has a biofilm-destroying effect, acting on bacterial membranes and cracking them.

Isazofos is a broad-spectrum organophosphate insecticide-nematicide that controls numerous pests of turf, such as nematode Radopholus similis. Isazofos is also effective in the control of rice gall midge.

HIV-1-IN-88 (compound 20a) is a potent HIV‑1 protease inhibitor (IC₅₀ = 10 pM) with an antiviral EC₅₀ of 10.4 nM. HIV-1-IN-88 exhibits potency against the multidrug-resistant variants HIV-1_Muta and HIV-1_I50V with EC₅₀ values of 30.0 and 34.3 nM, respectively. HIV-1-IN-88 can be used for HIV research.

Methyl isoferulate (Isoferulic acid methyl ester) is an anti-H1N1 swine flu compound. Methyl isoferulate exerts its anti-swine flu activity by blocking the influenza M2 proton channel.

Benastatin B is an inhibitor for glutathione S-transferase, that inhibits human pi class GST with an IC₅₀ of 1.10 μg/mL. Benastatin B exhibits board-spectrum antibacterial efficacy, inhibits MRSA with MIC 3.1 μg/mL. Benastatin B exhibits anti-inflammatory efficacy through inhibition of IgE mediated β-hexosaminidase release with an IC₅₀ of 79 μg/mL.

Crotoniazide (compound 9) is an isonicotinic acid hydrazide derivative with anti-HIV potential with an EC₅₀ value of 11 ug/mL.

Pinselin is a nitrogen-containing heterocyclic antibiotic. Pinselin has anti-yeast activity.

CHIKV nsP2 protease-IN-1(compound J13) is an oral active non-structural protein 2 protease inhibitor with the EC₅₀ of 0.39 μM aganist of CHIKV S27. CHIKV nsP2 protease-IN-1 can be used for study of Chikungunya virus.

4-Chloro-α-propylbenzeneacetonitrile is a PvdQ acylase competitive inhibitor with an IC₅₀ of 5.9 μM. 4-Chloro-α-propylbenzeneacetonitrile binds to the acyl-binding site of PvdQ to block acylase activity. 4-Chloro-α-propylbenzeneacetonitrile can be used for the research of Pseudomonas aeruginosa infection.

Favipiravir-¹³C3 is the ¹³C labeled isotope of Favipiravir (HY-14768). Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

Austroside A is found in Evodia austrosinensis. Austroside A shows antibacterial activity against the Staphylococcus aureus antibiotic resistant strain.

DHFR-IN-26 is an Escherichia coli dihydrofolate reductase (ecDHFR) inhibitor with an IC₅₀ of 0.75 nM. DHFR-IN-26 exerts broad-spectrum antibacterial activity. DHFR-IN-26 disrupts folate metabolism, nucleotide synthesis, and bacterial amino acid metabolic pathways. DHFR-IN-26 disrupts bacterial inner membranes, inhibited biofilm formation, and attenuated phage-related processes. DHFR-IN-26 shows lower toxicity to non-cancerous cells. DHFR-IN-26 can be used for the research of bacterial infections (including infections caused by methicillin-resistant Staphylococcus aureus, multidrug-resistant Escherichia coli, multidrug-resistant Pseudomonas aeruginosa, and lysogenic bacteria).

SARS-CoV-2 Mpro-IN-59 is a competitive, nonpeptidic SARS-CoV-2 M_pro inhibitor. SARS-CoV-2 Mpro-IN-59 can be used for the research of covid-19.

Lauryl sulfate (Dodecyl hydrogen sulphate) is an anionic chaotropic surfactant. Lauryl sulfate dissolves viral envelopes, denatures viral proteins, inhibits viral infectivity and HIV-1 syncytium formation. Lauryl sulfate potently inhibits the infectivity of HSV-1 strain F (ED₅₀ = 17.9 μM) and HSV-2 strain 333 (ED₅₀ = 32.7 μM). Lauryl sulfate induces environmental toxicity, disrupting environmental balance and physiological processes of organisms. As a contaminant, Lauryl sulfate is toxic to aquatic and terrestrial organisms. Lauryl sulfate can be used in studies related to sexually transmitted infections.