Infection

Dapivirine hydrochloride is a non-nucleoside reverse transcriptase inhibitor with antitumor activity. Dapivirine hydrochloride attenuates the proliferation of glioblastoma cells and induces apoptosis. Dapivirine hydrochloride modulates autophagy and activates Akt, Bad, and SAPK/JNK signaling pathways. Dapivirine hydrochloride has shown inhibitory effects on glioma cell growth both in vitro and in vivo. Dapivirine hydrochloride is also a promising drug candidate for topical microbial agents for the prevention of sexual transmission of HIV-1.

LBP-14, a peptide, is a synthetic fragment of the LPS (HY-D1056) binding protein (LBP) and is a LPS antagonist. LBP-14 interacts with LPS via electrostatic contacts between arginine/lysine residues and LPS phosphate groups, and hydrophobic contacts between aromatic/aliphatic residues and LPS acyl chains, blocking LPS binding to LBP. LBP-14 moderately inhibits LPS-induced TNF-α formation. LBP-14 can be used for the research of gram-negative sepsis.

Indanomycin is an antibiotic of the pyrroloketoindane class, which includes an unusual indane ring structure. It has bactericidal activity against Gram-positive bacteria, with minimum inhibitory concentration (MIC) values of ≤0.2 μg/mL.

Cap-dependent endonuclease-IN-5 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-5 inhibits influenza virus well, and/or has lower cytotoxicity, better in vivo pharmacokinetic properties and in vivo pharmacodynamic properties (extracted from patent WO2020078401A1, compound 13-1).

Dymanthine (N,N-Dimethyloctadecan-1-amine) is a broad-spectrum intestinal anthelmintic. Dymanthine is used in research related to various helminth infections (Ascaris lumbricoides, Trichuris trichiura, and Ancylostoma duodenale).

3-Methyl-1-hexanol, a volatile organic compound, is a microbial antagonist that can be isolated from Aureobasidium pullulans. 3-Methyl-1-hexanol has antifungal activities against Alternaria alternate and Botrytis cinerea. 3-Methyl-1-hexanol can be used for microbial infections research.

ANA975, 5-amino-3-β -D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one derivative, is an oral prodrug of the TLR-7 agonist Isatoribine (HY-13655A). ANA975 is converted to Isatoribine via a combined mechanism of hydrolysis by esterases and oxidation by aldehyde oxidase. ANA975 can be used in the research of hepatitis C virus infection.

AZ5385 is an EGFR-tyrosine kinase inhibitor. AZ5385 is a HRV-2 virus blocker, with EC₅₀ of 0.35 µM. AZ5385 affects the late stage of viral life cycle.

Zanamivir–cholesterol conjugate is a long-acting neuraminidase inhibitor with potent efficacy against drug-resistant influenza viruses.

AM4085 is an orally active Antagonist for FmlH with an IC₅₀ of 0.19 μM. AM4085 reveals metabolic stability in mouse liver microsomes and blood plasma.

CDK9-IN-34 (Compound 1b) is an inhibitor for CDK9 with an IC₅₀ of 0.25 μM. CDK9-IN-34 exhibits cytotoxicity to cancer cell HCT116, MCF7 and K652 with IC₅₀s of 1.43, 3.01 and 50.27 μM, respectively. CDK9-IN-34 exhibits antiviral activity against coronavirus 229E with an IC₅₀ of 145.92 μM.

Glenthmycin E is an antibacterial agent found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin E inhibits growth of multiple bacterial and exhibits no detectable cytotoxicity to eukaryotic cells including fungal and human carcinoma cells. Glenthmycin E can be used for the research of bacterial infections.

Strevertene A ((-)-Strevertene A) (Compound 1), a pentaene macrolide, is a microbial secondary metabolite. Strevertene A is an antibiotic and has a potent antifungal activity. Strevertene A significantly inhibits the mycelial growth of phytopathogenic fungi (such as Alternaria mali, Aspergillus oryzae and Cylindrocarpon destructans) with IC₅₀s of 4-16 μg/mL. Strevertenes A can strongly prevent Fusarium wilt development on tomato plants.

Furazolium hydrochloride is a broad-spectrum antibacterial agent with inhibitory activity against a variety of Gram-positive and Gram-negative Bacterial strains. In a gelatin-acacia complex coacervate system, Furazolium hydrochloride exhibits protein-binding properties, where protein binding dominates at low concentrations, while micellization occurs at high concentrations. Furazolium hydrochloride does not alter the water permeability of cellulose membranes, and it can induce delayed-type hypersensitivity reactions in guinea pigs, with cross-reactivity observed in animals sensitized with aflatoxin B1. Furazolium hydrochloride can be used in studies related to bacterial infections and local wound infections.

PqsR/LasR-IN-2 (Standard) is the analytical standard of PqsR/LasR-IN-2. This product is intended for research and analytical applications. PqsR/LasR-IN-2 (Compound 3) is a potent inhibitor of PqsR and LasR systems in P. aeruginosa. PqsR/LasR-IN-2 also inhibits hERG with the IC50 of 1.408 µM[1].

XT17 is an anthrone compound with broad-spectrum antibacterial activity. It exerts its antibacterial effect by disrupting the cell wall and inhibiting DNA synthesis. XT17 exhibits weak hemolytic activity, low cytotoxicity against mammalian cell lines, and a low frequency of drug resistance. Meanwhile, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies have confirmed that XT17 can form a stable complex with bacterial gyrase. XT17 can be used in the research of the anti - infection field.

SB-734117 is a human cytomegalovirus (HCMV) replication inhibitor that prevents CREB and histone H3 post-translational modifications.

3-Deoxyaphidicolin exhibits phytotoxic efficacy, that inhibits root growth of lettuce seedlings. 3-Deoxyaphidicolin also exhibits leishmanicidal activity against Leishmania major and Leishmania braziliensis.

PTD-N5-1 acetate is an IRF5 inhibitory peptide. PTD-N5-1 acetate blocks the activation of IRF5. PTD-N5-1 acetate inhibits β-glucan-induced IL-12 production in bone marrow-derived dendritic cells pre-stimulated with IFN-γ. PTD-N5-1 acetate reduces the levels of IL-12 and IFN-γ in the kidneys of mice with Candida albicans infection. PTD-N5-1 acetate is applicable to the research of Candida albicans infection.

Nigella sativa extract (seed) is a seed extract of black cumin that contains a variety of bioactive components.