Metabolic Disease

Pyridindolol (NSC 266530) is a β-galactosidase inhibitor. Pyridindolol can be produced by actinomycetes.

SB 415286 (Standard) is the analytical standard of SB 415286. This product is intended for research and analytical applications. SB 415286 is a potent and selective cell permeable inhibitor of GSK-3α, with an IC50 of 77.5 nM, and a Ki of 30.75 nM; SB 415286 is equally effective at inhibiting human GSK-3α and GSK-3β.

MK-4074 (Standard) is the analytical standard of MK-4074 (HY-107709). This product is intended for research and analytical applications. MK-4074 is a liver-specific inhibitor of acetyl-CoA carboxylase ACC1 and ACC2 with IC₅₀ values of approximately 3 nM.

2,5-Diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine is a metabolite in the biosynthesis pathway (purine metabolism process) of Riboflavin (HY-B0456).

11β-Hydroxy-17α-methyltestosterone is a metabolite of 17α-methyltestosterone.

5-Hydroxyoxindole is a structural analog of uric acid for its antioxidant. 5-Hydroxyoxindole has DPPH radical scavenging activities and lipid peroxidation-inhibitory activities. 5-Hydroxyoxindole is a product of partial metabolism of tryptophan involving conversion in the gut lumen of tryptophan to indole through the action of bacterial tryptophanase and tryptophan synthase. 5-Hydroxyoxindole is one of the main molecules responsible for the neurological symptoms of hepatic encephalopathy in rats. 5-Hydroxyoxindole can be used for the research of oxidative stress-mediated disorders.

cis-12,13-Epoxy-9(Z),15(Z)-octadecadienoic acid is an ester product.

Anti-Mouse TIM-4 Antibody (RMT4-54) is a rat-derived IgG2a κ type antibody inhibitor, targeting to mouse TIM-4. Anti-Mouse TIM-4 Antibody (RMT4-54) reacts with mouse T cell immunoglobulin and mucin domain 4 (TIM-4) and blocks TIM-4 signaling. Anti-Mouse TIM-4 Antibody (RMT4-54) inhibits phagocytosis of apoptotic cells. Anti-Mouse TIM-4 Antibody (RMT4-54) can be used for the researches of immunology and metabolic disease.

Lysyllysine trihydrochloride (L-Lysyl-L-lysine trihydrochloride) is an orally active PepT1 substrate. Lysyllysine trihydrochloride enhances whole-body protein synthesis, improves intestinal structure, alleviates intestinal mucosal inflammation, and exhibits higher lysine bioavailability in neonatal piglets with PN-induced intestinal atrophy. Lysyllysine trihydrochloride inhibits the growth of axenic cyanobacterial strains and induces their cell lysis. Lysyllysine trihydrochloride can be used in studies related to intestinal atrophy and metabolism.

Benfluorex (hydrochloride) (Standard) is the analytical standard of Benfluorex (hydrochloride). This product is intended for research and analytical applications. Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator.

8(R)-Hydroxyoctadecanoic acid is an ester product.

13(Z),16(Z),19(Z)-Docosatrienoyl chloride is an ester product.

Heptacosane (Standard) is the analytical standard of Heptacosane. This product is intended for research and analytical applications. Heptacosane is an ester product.

1,3-Digamma linolenin is an acylglycerol.

MCPD dioleate (1,2-Dioleoyl-3-chloropropanediol) is an ester product.

L-Palmitoylcarnitine-d₉ is deuterium labeled L-Palmitoylcarnitine. L-Palmitoylcarnitine, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine inhibits K_ATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.

Diethylumbelliferyl phosphate (DEUP), a selective and potent inhibitor of cholesterol esterase, does not inhibit protein kinase activity A in vitro, and it effectively disrupts steroidogenesis by blocking the transport of cholesterol into the mitochondria of steroidogenic cells, with an IC₅₀ of 11.6 μM, potentially limiting dietary cholesterol absorption.

p-Toluic acid (Standard) is the analytical standard of p-Toluic acid. This product is intended for research and analytical applications. p-Toluic acid (4-Methylbenzoic acid), coumarin, is a substituted benzoic acid. p-Toluic acidis synthetic p-aminomethylbenzoic acid (PAMBA), intermediates such as p-toluonitrile. p-Toluic acidMay have potential reproductive toxicity, press 1g/kgRepeated administration of doses can produce a variety of adverse effects on the epididymis.

Anti-Monkey/Human CD20 Antibody (2H7) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to monkey/human CD20. Anti-Monkey/Human CD20 Antibody (2H7) specifically depletes B cells. Anti-Monkey/Human CD20 Antibody (2H7) can be used for the researches of inflammation and metabolic disease, such as diabetes and experimental autoimmune encephalomyelitis.

3β,25-OH-7-Oxo-5-cholestenoic acid is an oxysterol.