5-HT Receptor
Serotonin Receptor; 5-hydroxytryptamine Receptor
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.
5-HT Receptor Isoform Specific Products
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5-HT Receptor
(569)
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5-HT1 Receptor
(458)
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5-HT2 Receptor
(478)
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5-HT3 Receptor
(34)
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5-HT4 Receptor
(18)
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5-HT5 Receptor
(14)
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5-HT6 Receptor
(86)
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5-HT7 Receptor
(89)
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All Product Categories
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5-HT Receptor Inhibitors
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5-HT Receptor Agonists
(554)
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5-HT Receptor Antagonists
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5-HT Receptor Activators
(19)
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5-HT Receptor Modulators
(98)
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5-HT Receptor Inducers
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5-HT Receptor Controls
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5-HT Receptor Ligands
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5-HT Receptor Related Products (1756)
Related Products (1756)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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5-HT Receptor Isoform Comparison
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SB-699551 free base
0 ImagesCat. No.: HY-136700CAS No.: 791789-61-2SB-699551 free base is a selective and brain penetrant 5-HT5A receptor antagonist with a pKi of 8.2 nM. SB-699551 free base shows high selectivity over most other 5-HT receptor subtypes, dopamine receptors, and α1B adrenoceptor. SB-699551 free base disrupts Gαi/o-coupled and PI3K/AKT/mTOR signaling pathways, alters CREB, ATF1, AKT, PRAS40, S6K, and FOXO1 phosphorylation in breast tumor cells. SB-699551 free base can be used for the research of anxiety, breast cancer, and Alzheimer's disease.
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25I-NBMD hydrochloride
0 ImagesCat. No.: HY-138237CAS No.: 1539266-14-225I-NBMD hydrochloride is a derivative of the phenethylamine 2C-I that increases the affinity and activity at the 5-HT2A receptor.
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Rotigotine (Standard)
0 ImagesSynonyms: N-0923 (Standard); (-)-N 0437 (Standard)Rotigotine (Standard) is the analytical standard of Rotigotine. This product is intended for research and analytical applications. Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research.
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(E)-[10]-Shogaol
![(E)-[10]-Shogaol](https://file.medchemexpress.com/product_pic/hy-n2434a.gif "Click to View (E)-[10]-Shogaol Product Detail")
0 ImagesCat. No.: HY-N2434ACAS No.: 104186-05-2(E)-[10]-Shogaol is a 5-HT1A receptor partial agonist found in Zingiber officinale, with a Ki of 5.84 μM. (E)-[10]-Shogaol may be used in research on anxiety and depression.
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Dolasetron Mesylate
0 ImagesCat. No.: HY-B0750ACAS No.: 115956-13-3Synonyms: MDL-73147EFDolasetron Mesylate (MDL-73147EF) is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.
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Altanserin (Standard)
0 ImagesAltanserin (Standard) is the analytical standard of Altanserin. This product is intended for research and analytical applications. Altanserin can synthesize Fluorine-18 Altanserin. Fluorine-18 Altanserin binds to the brain 5HT2 receptors.
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Eletriptan hydrobromide (Standard)
0 ImagesSynonyms: Eletriptan HBr (Standard); UK-116044 hydrobromide (Standard)Eletriptan hydrobromide (Standard) is an analytical standard for Eletriptan hydrobromide. This product is intended for research and analytical applications. Eletriptan hydrobromide (Eletriptan HBr) is a 5-HT1B and 5-HT1D receptor agonist with antimigraine activity, with Ki of 0.92 nM and 3.14 nM, respectively.
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8 Hydroxy PIPAT
0 ImagesCat. No.: HY-101225ACAS No.: 159651-91-98 Hydroxy PIPAT is a 5-HT1A receptor agonist that promotes histamine release. 8 Hydroxy PIPAT selectively activates 5-HT1A receptors, thereby triggering mast cell degranulation and histamine release. 8 Hydroxy PIPAT is applicable to research related to irritable bowel syndrome.
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Tedatioxetine hydrobromide (Standard)
0 ImagesSynonyms: Lu AA24530 hydrobromide (Standard)Tedatioxetine hydrobromide (Standard) (Lu AA24530 hydrobromide (Standard)) is the analytical standard of Tedatioxetine hydrobromide (HY-101755). This product is intended for research and analytical applications. Tedatioxetine (Lu AA24530) hydrobromide acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist. ,
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2-(1-Piperazinyl)pyrimidine (Standard)
0 Images2-(1-Piperazinyl)pyrimidine Standard is the analytical standard of 2-(1-Piperazinyl)pyrimidine (HY-W004464). This product is intended for research and analytical applications. 2-(1-Piperazinyl)pyrimidine is an orally effective α2-adrenoceptor antagonist and 5-HT1A receptor agonist. 2-(1-Piperazinyl)pyrimidine is an in vivo metabolite related to buspirone. 2-(1-Piperazinyl)pyrimidine modulates excitatory synaptic transmission in the hippocampus and the release of monoamine transmitters such as norepinephrine and 5-HT by blocking α2-adrenoceptor and activating 5-HT1A Receptor. 2-(1-Piperazinyl)pyrimidine is used in research on psychiatric disorders such as anxiety and depression.
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Cinanserin hydrochloride (Standard)
0 ImagesCat. No.: HY-100943RCAS No.: 54-84-2Synonyms: SQ 10643 (Standard)Cinanserin (hydrochloride) (Standard) is the analytical standard of Cinanserin (hydrochloride) (HY-100943). This product is intended for research and analytical applications. Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro.
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SC-53116
0 ImagesCat. No.: HY-123747CAS No.: 141196-99-8SC-53116 is a selective 5-HT4 receptor agonist with EC50 at 23 nM.
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Decloxizine (Standard)
0 ImagesDecloxizine (UCB-1402; NSC289116) (Standard) is the analytical standard of Decloxizine. This product is intended for research and analytical applications.Decloxizine is an orally active bronchodilator that can penetrate the blood-brain barrier. Decloxizine is a piperazine-type H1 histamine receptor antagonist. Decloxizine selectively blocks H1 histamine receptors, inhibiting histamine-induced capillary dilation, edema, and itching. Decloxizine has some 5-HT2 receptor antagonistic activity. Decloxizine can be used in studies of urticaria, allergic rhinitis, and bronchial asthma.
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LY108742
0 ImagesCat. No.: HY-116606CAS No.: 150196-69-3LY108742 is a 5-HT2 receptor antagonist, with IC50 values of 9.3 nM (Rat), 57.2 nM (Pig), 56.8 nM (Monkey).
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ST1936 (Standard)
0 ImagesCat. No.: HY-103110RCAS No.: 1210-81-7ST1936 (Standard) is the analytical standard of ST1936 (HY-103110). This product is intended for research and analytical applications. ST1936 is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 also shows moderate affinity (Ki of 300 nM) for human and rat α2 adrenergic receptor.
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Nelotanserin (Standard)
0 ImagesCat. No.: HY-10559RCAS No.: 839713-36-9Synonyms: APD125 (Standard)Nelotanserin (Standard) is the analytical standard of Nelotanserin (HY-10559). This product is intended for research and analytical applications. Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively.
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Quipazine (Standard)
0 ImagesCat. No.: HY-W028142RCAS No.: 4774-24-7Quipazine is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine behaves as a 5-HT3R agonist in peripheral models. Quipazine can be used for neurological disease research.
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5-Methoxytryptamine hydrochloride (Standard)
0 ImagesCat. No.: HY-W015169ARCAS No.: 66-83-15-Methoxytryptamine (hydrochloride) (Standard) is the analytical standard of 5-Methoxytryptamine (hydrochloride) (HY-W015169A). This product is intended for research and analytical applications. 5-Methoxytryptamine hydrochloride, a metabolite of Melatonin, is a nonselective 5-HT receptor agonist. 5-Methoxytryptamine hydrochloride has no affinity for the 5-HT3 receptor. 5-Methoxytryptamine hydrochloride is also a potent antioxidant and has radioprotective action.
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Loxapine-d8 hydrochloride
0 ImagesCat. No.: HY-17390BSCAS No.: 1246820-19-8Loxapine-d8 hydrochloride is the deuterium labeled Loxapine. Loxapine Succinate is a D2DR and D4DR inhibitor, serotonergic receptor antagonist and also a dibenzoxazepine anti-psychotic agent.
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18-Methoxycoronaridine
0 ImagesCat. No.: HY-106980CAS No.: 308123-60-6Synonyms: (-)-18-Methoxycoronaridine18-Methoxycoronaridine ((-)-18-Methoxycoronaridine) is an orally active and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist. 18-Methoxycoronaridine is an inhibitor of serotonin transporter (SERT) and norepinephrine transporter (NET), with IC50 values of 51.6 μM and 121 μM for SERT and NET, respectively. 18-Methoxycoronaridine inhibits the function of SERT and NET, promotes 5-HT3A receptor desensitization, blocks α3β4 nAChR, and modulates receptor signaling pathways associated with reinforcement. 18-Methoxycoronaridine also exhibits potent antiparasitic activity. 18-Methoxycoronaridine can be used in research related to depression, obesity, alcoholism, smoking addiction, and cutaneous leishmaniasis.
