5-HT Receptor
Serotonin Receptor; 5-hydroxytryptamine Receptor
5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. Type: 5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, 5-HT7. They mediate both excitatory and inhibitory neurotransmission. The serotonin receptors are activated by the neurotransmitter serotonin, which acts as their natural ligand. The serotonin receptors modulate the release of many neurotransmitters, as well as many hormones. The serotonin receptors influence various biological and neurological processes such as aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, andthermoregulation. The serotonin receptors are the target of a variety of pharmaceutical drugs, including many antidepressants, antipsychotics, anorectics,antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens.
5-HT Receptor Isoform Specific Products
-
5-HT Receptor
(567)
View all products
-
5-HT1 Receptor
(458)
View all products
-
5-HT2 Receptor
(478)
View all products
-
5-HT3 Receptor
(34)
View all products
-
5-HT4 Receptor
(18)
View all products
-
5-HT5 Receptor
(14)
View all products
-
5-HT6 Receptor
(86)
View all products
-
5-HT7 Receptor
(89)
View all products
All Product Categories
-
5-HT Receptor Inhibitors
(197)
View all products
-
5-HT Receptor Agonists
(553)
View all products
-
5-HT Receptor Antagonists
(683)
View all products
-
5-HT Receptor Activators
(19)
View all products
-
5-HT Receptor Modulators
(98)
View all products
-
5-HT Receptor Inducers
(2)
View all products
-
5-HT Receptor Controls
(19)
View all products
-
5-HT Receptor Ligands
(32)
View all products
-
5-HT Receptor Related Products (1754)
Related Products (1754)
-
Antibodies (1)
-
Related Compound Screening Libraries (1)
-
5-HT Receptor Isoform Comparison
-
SB 242084 dihydrochloride (Standard)
0 ImagesCat. No.: HY-13409ARCAS No.: 1049747-87-6SB 242084 (dihydrochloride) (Standard) is the analytical standard of SB 242084 (dihydrochloride). This product is intended for research and analytical applications. SB 242084 dihydrochloride is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 dihydrochloride increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 dihydrochloride also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 dihydrochloride has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage.
-
Norbaeocystin
0 ImagesCat. No.: HY-168809CAS No.: 21420-59-7Norbaeocystin is an intermediate/minor metabolite naturally present in the psilocybin biosynthetic pathway of hallucinogenic mushrooms (Psilocybe spp.). Norbaeocystin has weak or no affinity for the serotonin 2A (5-HT2A) receptor and does not induce receptor activation. Norbaeocystin is rapidly metabolized by monoamine oxidase, and thus does not participate in centrally mediated psychedelic effects. Norbaeocystin can be used for studies on biological pathways associated with hallucinogenic effects.
-
Vortioxetine-d4
0 ImagesCat. No.: HY-15414S2Synonyms: Lu AA 21004-d4Vortioxetine-d4 (Lu AA 21004-d4) is the deuterium labeled Vortioxetine (HY-15414). Vortioxetine is an antagonist of 5-HT3A and 5-HT7 receptors (Ki: 3.7 nM, 19 nM) and an inhibitor of serotonin transporter (SERT) (Ki: 1.6 nM), as well as a 5-HT1A agonist and a partial agonist of 5-HT1B (Ki: 15 nM, 33 nM).
-
Teniloxazine
0 ImagesCat. No.: HY-164009CAS No.: 62473-79-4Teniloxazine is an inhibitor for norepinephrine neuronal reuptake and an weak inhibitor for reuptake of Serotonin (HY-B1473A) and Dopamine (HY-B0451). Teniloxazine exhibits antidepressant, antihypoxic and anti-amnestic properties without anticholinergic, sedative, and cardiovascular adverse effects.
-
Aramisulpride (Standard)
0 ImagesCat. No.: HY-109167RCAS No.: 71675-90-6Synonyms: (R)-Amisulpride (Standard); (R)-Esamisulpride (Standard); (R)-DAN 2163 (Standard)Aramisulpride (Standard) is the analytical standard of Aramisulpride (HY-109167). This product is intended for research and analytical applications. Aramisulpride (R-(+)-Amisulpride) is the R-isomer of Amisulpride (HY-14545). Aramisulpride is a 5-HT7 receptor antagonist with a Ki value of 22 nM. Aramisulpride is a D2/D3 receptor antagonist with a Ki value of 140 nM for D2R and a Ki value of 13.9 nM for D3R. Aramisulpride can be used in psychiatric research.
-
Granisetron-d3
0 ImagesCat. No.: HY-132348SCAS No.: 1224925-64-7Granisetron-d3 is the deuterium labeled Granisetron. Granisetron (BRL 43694) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
-
3C-B-FLY hydrochloride
0 ImagesCat. No.: HY-130393CAS No.: 178557-19-23C-B-FLY hydrochloride is an α-methylated analog of 2C-B-FLY.
-
Sarizotan (Standard)
0 ImagesCat. No.: HY-100820RCAS No.: 351862-32-3Synonyms: EMD 128130 (Standard)Sarizotan (Standard) is the analytical standard of Sarizotan. This product is intended for research and analytical applications. Sarizotan (EMD 128130) is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively.
-
5-Methoxytryptoline
0 ImagesCat. No.: HY-177797CAS No.: 30439-19-15-Methoxytryptoline acts as a modulator of the Serotonin transporter complex, as well as a ligand for the 5-HT2A and 5-HT2C receptors, with Ki values of 130 nM and 140 nM for the 5-HT2A and 5-HT2C receptors, respectively. 5-Methoxytryptoline inhibits the active uptake of Serotonin (HY-B1473A) and Tryptamine (HY-B2132) in platelets. 5-Methoxytryptoline induces behavioral excitation, cortical electroencephalographic desynchronization, and dose-dependent elevation of plasma prolactin, followed by behavioral sedation and partial recovery of cortical electroencephalographic voltage. 5-Methoxytryptoline antagonizes Reserpine (HY-N0480)-induced sedation, reduced locomotor activity, and hypothermia. 5-Methoxytryptoline exerts dose-dependent effects on behavior and cortical electroencephalographic activity in freely moving rats. 5-Methoxytryptoline can be used in depression-related research.
-
Paliperidone (Standard)
0 ImagesSynonyms: 9-Hydroxyrisperidone (Standard)Paliperidone (Standard) is the analytical standard of Paliperidone. This product is intended for research and analytical applications. Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and 5-HT2A antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia.
-
CE-103
0 ImagesCat. No.: HY-W1133231CAS No.: 1879038-73-9CE-103 is a selective, blood-brain barrier-permeable dopamine transporter (DAT) inhibitor with an IC50 of 14.73 μM. CE-103 blocks DAT-mediated dopamine reuptake and exhibits antagonistic activity against 5-HT1A. CE-103 reduces working memory errors in the radial arm maze test of rats, decreases the levels of complexes containing phosphorylated DAT (pDAT) and D1R in the hippocampus of rats, and increases the levels of complexes containing D2R and D3R simultaneously. CE-103 can be used in studies related to dopaminergic neurotransmission, working memory and cognitive function.
-
Alosetron (Hydrochloride(1:X))
0 ImagesCat. No.: HY-70050CAS No.: 132414-02-9Synonyms: GR 68755 (Hydrochloride(1:X)); GR 68755X (Hydrochloride(1:X))Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride(1:X) is used for the research of irritable bowel syndrome (IBS). Alosetron Hydrochloride(1:X) blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride(1:X) attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.
-
(S)-Cilansetron
0 ImagesCat. No.: HY-105109BCAS No.: 120635-77-0(S)-Cilansetron is the S-isomer of Cilansetron. Cilansetron is a 5-HT3 receptor antagonist that can be used in research related to irritable bowel syndrome.
-
SR 57227A (Standard)
0 ImagesCat. No.: HY-102064RCAS No.: 77145-61-0SR 57227A (Standard) is the analytical standard of SR 57227A (HY-102064). This product is intended for research and analytical applications. SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects.
-
Tipindole
0 ImagesTipindole is a serotonin antagonist. Tipindole can be used in depression research.
-
Arotinolol (Standard)
0 ImagesCat. No.: HY-122537ARCAS No.: 68377-92-4Arotinolol (Standard) is the analytical standard of Arotinolol. This product is intended for research and analytical applications. Arotinolol is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases.
-
Opiranserin hydrochloride (Standard)
0 ImagesCat. No.: HY-109067ARCAS No.: 1440796-75-7Synonyms: VVZ-149 hydrochloride (Standard)Opiranserin hydrochloride (Standard) is the analytical standard of Opiranserin (hydrochloride) (HY-109067A). This product is intended for research and analytical applications. Opiranserin (VVZ-149) hydrochloride, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin hydrochloride shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin hydrochloride is development as an injectable agent for the treatment of postoperative pain.
-
Granisetron-d6 Hydrochloride
0 ImagesCat. No.: HY-B0071ASSynonyms: BRL 43694A-d6Granisetron-d6 (Hydrochloride) (BRL 43694A-d6) is deuterium labeled Granisetron (Hydrochloride). Granisetron (Hydrochloride) (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.
-
Dopamine D3 receptor ligand-5
0 ImagesCat. No.: HY-156239CAS No.: 2899250-94-1Dopamine D3 receptor ligand-5 (13a), a Cariprazine (HY-14763) analogue, is a dopamine D3 receptor ligand, with Ki values of 2.85 nM and 0.14 nM for D2R and D3R, respectively.
