2. Signaling Pathways
  3. Protein Tyrosine Kinase/RTK
  4. Ack1
  5. Ack1 Inhibitor

Ack1 Inhibitor

Ack1 Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-15290
    AIM-100
    		Inhibitor 99.95%
    AIM-100 is a potent and selective Ack1 inhibitor with an IC50 of 21.58 nM. AIM-100 also inhibits Tyr267 phosphorylation. AIM-100 does not inhibits other kinases including PI3-kinase and AKT subfamily members. AIM-100 has an anticancer effect.
  • HY-10943
    GNF-7
    		Inhibitor 98.93%
    GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-AblWT and Bcr-AblT315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies.
  • HY-12331
    KRCA-0008
    		Inhibitor 98.88%
    KRCA-0008 is a selective ALK/Ack1 inhibitor with IC50s of 12 and 4 nM for ALK and Ack1, respectively. KRCA-0008 can be used for the research of cancer.