Bacterial Inhibitor

Diethylcarbamazine (Standard) is the analytical standard of Diethylcarbamazine (HY-12642A). This product is intended for research and analytical applications. Diethylcarbamazine is an orally active microfilaricidal agent used originally in onchocerciasis and lymphatic filiariasis. Diethylcarbamazine reduces eosinophil trafficking to the lung tissue and exerts anti-allergic effects. Diethylcarbamazine reduces serum levels of leptin, TNF-α, IL-6, MCP-1, glucose, insulin, and triglycerides, and ameliorates insulin resistance without altering body, liver, or adipose tissue weights. Diethylcarbamazine enhances reactive oxygen intermediate expression by polymorphonuclear neutrophils, increases lymphocyte proliferation, and inhibits actinomycetoma lesion development. Diethylcarbamazine can be used for the researches of bronchial asthma, insulin resistance and infection.

ZTB23(R) is a potent and selective Mycobacterium tuberculosis zinc metalloproteinase-1 (Zmp1) inhibitor with K_i value of 0.054 μM. ZTB23(R) can be used for tuberculosis (TB) research.

Julimycin B2 has anti-Gram-positive bacteria and anti-virus activity and it has effects on ehrman ascites carcinoma in mice.

Antibacterial agent 324 is an amphipathic antibacterial agent. Antibacterial agent 324 exhibits selective activity against Gram-positive bacteria, with limited activity against enterococci and weak activity against Gram-negative bacteria.

Epelmycin E has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin.

Finafloxacin-d₄ (hydrochloride) is deuterium-labeled Finafloxacin (hydrochloride) (HY-13451A).

Cyclothialidine ( Ro 09-1437) is a potent DNA gyrase inhibitor isolated from Streptomyces filipinensisNR0484.

Miyakamide A2 is an antibiotic with insecticidal effect. Miyakamide A2 inhibits the growth of Artemia salina. Miyakamide A2 has a weak antixanthomonas activity. Miyakamide A2 inhibits P388 cells with an IC₅₀ of 12.2 μg/mL.

Terrestribisamide ((E)-N,N′-Diferuloylputrescine) can be isolated from dried fruits of Tribulus terrestris. Terrestribisamide has antibacterial, antifungal, antioxidant, anticancer effects.

Chloropolysporin B has strong activity of anti-Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and enterococcus bacteria.

GlmU-IN-1 is an inhibitor of the GlmU acetyltransferase domain in Escherichia coli and Haemophilus influenzae. GlmU-IN-1 acts as a competitive inhibitor of AcCoA and a non-competitive inhibitor of GlcN-1-P. GlmU-IN-1 targets the acetyltransferase domain of bacterial GlmU, interferes with the biosynthesis of UDP‑GlcNAc, and impairs bacterial cell wall integrity. GlmU-IN-1 can be used for the research of Gram-negative bacterial infections.

Deoxyfrenolicin is a quinone antibiotic that can be isolated from the fermentation broth of the Streptomyces roseofulvus strain AM-3867. Deoxyfrenolicin belongs to the frenolicin class of antibiotics. Deoxyfrenolicin exhibits antibacterial activity in vitro and can effectively inhibit the activity of Mycoplasma gallisepticum.

Cerexin B1 has anti-Gram-positive bacterial activity.

Saquayamycin B1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin B1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells.

Porothramycin B is an antibiotic. Porothramycin B has activity against Gram-positive bacteria and anaerobic bacteria.

Methicillin (sodium salt) (Standard) is the analytical standard of Methicillin (sodium salt). This product is intended for research and analytical applications. Methicillin sodium salt (Meticillin sodium) is a β-lactam, semi-synthetic antibiotic related to penicillin antibiotic. Methicillin sodium salt inhibits penicillin-binding proteins involved in the synthesis of peptidoglycan. Methicillin sodium salt inhibits S. aureus with a MIC value of 2.1 μg/mL. Methicillin sodium salt can be used for the research of inflammation.

Antibacterial agent 286 (compound 5) is an effective broad-spectrum antimicrobial agent with strong inhibitory activity against methicillin-resistant S. aureus (MRSA) with an MIC of 25 μg/mL.

Pacidamycin 32 has inhibitory effect on Pseudomonas aeruginosa. Pacidamycin 3 also has effect on a few strains of bacteria such as Suppurative staphylococcus and Escherichia coli.

Sakyomicin D is a Benzoquinone antibiotic. Sakyomicin D has activity against Gram-positive bacteria.

Megovalicin A has the effect against Bacillus Subtilis and Escherichia coli.