Bacterial Inhibitor

Pluracidomycin D is a carbapenem antibiotic. Pluracidomycin D has anti-Gram-positive bacteria and Gram-negative bacteria activities.

Arphamenine B is a Zn²⁺-dependent exopeptidase that selectively removes arginine and/or lysine residues from the NH2-terminus of several peptide substrates. Arphamenine B is an inhibitor of aminopeptidase B that can be isolated from bacteria. Arphamenine B enhances the immune response and is used to characterize novel proteases.

7-Aminocephalosporanic acid (Standard) is the analytical standard of 7-Aminocephalosporanic acid. This product is intended for research and analytical applications. 7-aminocephalosporanic acid (7-ACA) is a HSP90β inhibitor and an antibiotic. 7-Aminocephalosporanic acid is the core chemical structure of the synthesis of cephalosporin antibiotics and an effective β-lactamase inhibitor.

Lapyrium is a broad-spectrum antimicrobial surfactant.

Pyloricidin A is an antibiotic against Helicobacter pylori found in Bacillus sp. HC-70. Pyloricidin A has strong anti-Helicobacter pylori activity. Pyloricidin A has no activity against other bacteria and yeast.

Sutezolid-¹³C₄ (PNU-100480-¹³C₄) is ¹³C labeled Sutezolid. Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis.

DDA-tetracycline is a tetracycline derivative (4-des-dimethylaminotetracycline, also called CMT-1).DDA-tetracycline is subject to conflicting classification, with one source noting no definitive identity or classification, and specifying the abbreviation 'DDA' may refer to the disk diffusion agar method rather than the reagent itself.

Dihydrogranaticin has anti-Bacillus cereus activity.

Darlucin B has antibacterial and fungi activity, and weak cytotoxicity.

Coumermycin A2 has anti-Gram positive bacteria, negative bacteria, mycobacterium (weak) activity.

Irinotecan (hydrochloride) (Standard) is the analytical standard of Irinotecan (hydrochloride). This product is intended for research and analytical applications. Irinotecan hydrochloride ((+)-Irinotecan hydrochloride) is a topoisomerase I inhibitor mainly used to treat colon cancer and rectal cancer.

Tenuigenin (Standard) is the analytical standard of Tenuigenin. This product is intended for research and analytical applications. Tenuigenin is a major active component isolated from the root of the Chinese herb Polygala tenuifolia. Tenuigenin protects against S.aureus-induced pneumonia by inhibiting NF-κB activation. Tenuigenin has anti-inflammatory effect.

Antituberculosis agent-17 (compound 21) is a potent and selective antituberculosis agent. Antituberculosis agent-17 displays excellent anti-Tuberculosis (TB) activity against H37Rv, MDR and XDR strains of TB (MIC = 0.2-0.78 μM). Antituberculosis agent-17 exhibits selectivity for Mycobacterium tuberculosis over selected non-TB forming mycobacteria and bacteria. Antituberculosis agent-17 can be used for TB research.

Antibacterial agent 317 (Compound 5h) is an antibacterial agent. Antibacterial agent 317 has multiple antibacterial mechanisms, including enhancing cell membrane permeability, inhibiting EPS production and cell membrane formation, and also interfering with flagella and methionine biosynthesis. Antibacterial agent 317 significantly suppresses the growth of tested plant pathogens, namely, Xanthomonas oryzae pv oryzicola (Xoc) and Xanthomonas oryzae pv oryzae (Xoo) with EC₅₀ values of 1.53 and 6.07 μg/mL, respectively.

Azithromycin-amide-C3-amide-quinoxaline (Compound 5f) is an Azithromycin (HY-17506) derivative and antibacterial agent. Azithromycin-amide-C3-amide-quinoxaline inhibits topoisoisomerase I with an IC₅₀ of 120.7 μM. Azithromycin-amide-C3-amide-quinoxaline interacts with 70S E. coli ribosome with a K_d of 0.8 nM. Azithromycin-amide-C3-amide-quinoxaline inhibits bacterial translation with an IC₅₀ of 0.7 μM. Azithromycin-amide-C3-amide-quinoxaline shows antibacterial potency against S. pneumonia ATCC 49619, S. aureus ATCC 29213, E. faecalis ATCC 29212 with MICs of 0.06 μg/mL, 2 μg/mL, 0.5 μg/mL, respectively. Azithromycin-amide-C3-amide-quinoxaline exhibits anticancer activity against prostate cancer, colon cancer.

Carbonic anhydrase-IN-2 is an orally active carbonic anhydrase inhibitor. Carbonic anhydrase-IN-2 shows antibacterial effect against various vancomycin-resistant Enterococcus (VRE) strains. Carbonic anhydrase-IN-2 can be used for the research of infection, such as E. faecium.

KY-9 is an antibacterial active compound.

Linolenyl alcohol (Standard) is the analytical standard of Linolenyl alcohol. This product is intended for research and analytical applications. Linolenyl alcohol is an unsaturated alcohol that inhibits Gram-positive bacteria.

Anhydrotetracycline (hydrochloride) (Standard) is the analytical standard of Anhydrotetracycline (hydrochloride). This product is intended for research and analytical applications. Anhydrotetracycline hydrochloride, a tetracycline biosynthetic precursor, is a potent competitive broad-spectrum tetracycline destructase enzymes inhibitor. Anhydrotetracycline hydrochloride is an effector for tetracycline controlled gene expression systems in eukaryotic cells.

Guaijaverin (Standard) is the analytical standard of Guaijaverin. This product is intended for research and analytical applications. Guaijaverin is a urease inhibitor with an IC₅₀ of 120 μM. Guaijaverin shows antioxidant and anti-Streptococcus mutans activities.