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CRFR Related Products (61)
Related Products (61)
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Urotensin I TFA
0 ImagesCat. No.: HY-P1542BSynonyms: Catostomus urotensin I TFAUrotensin I (Catostomus urotensin I) TFA, a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively.
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Urocortin III, mouse
0 ImagesUrocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.
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Urotensin I
0 ImagesCat. No.: HY-P1542CAS No.: 83930-33-0Synonyms: Catostomus urotensin IUrotensin I (Catostomus urotensin I), a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively.
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Urocortin III (human) TFA
0 ImagesCat. No.: HY-P3019AUrocortin III (human) TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) TFA preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) TFA potently binds to type 2 CRF receptors, specifically mCRF2β (Ki = 13.5 nM) and rCRF2α (Ki = 21.7 nM), while demonstrating negligible affinity for hCRF1 (Ki >100 nM). Urocortin III (human) TFA mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion.
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Emicerfont
0 ImagesSynonyms: GW876008Emicerfont is a corticotropin-releasing factor type 1 (CRF1) receptor antagonist with an IC50 of 66 nM.
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Urocortin III (human)
0 ImagesUrocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates CRF-R2 and has a discrete central nervous system and peripheral distribution. Urocortin III (human) potently binds to type 2 CRF receptors, specifically mCRF2β (Ki = 13.5 nM) and rCRF2α (Ki = 21.7 nM), while demonstrating negligible affinity for hCRF1 (Ki >100 nM). Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion[1][2].
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NVS-CRF38
0 ImagesCat. No.: HY-12339CAS No.: 1207258-55-6NVS-CRF38 is a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with low water solubility.
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CP 154526
0 ImagesCat. No.: HY-12130CAS No.: 157286-86-7CP 154526 is a potent, brain-penetrant and selective corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki of 2.7 nM. CP 154526 shows selective for CRF1 over CRF2 (Ki = >10 μM). CP 154526 has anxiolytic activities.
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DMP 904
0 ImagesCat. No.: HY-12132CAS No.: 202579-74-6DMP 904 is a noncompetitive full corticotropin-releasing factor receptor (CRFR) antagonist. DMP 904 can inhibit CRF-stimulated adenylate cyclase activity and ACTH release. DMP 904 exhibits anti-depressant and anti-anxiety activity.
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CRF, bovine
0 ImagesCat. No.: HY-P1533CAS No.: 92307-52-3Synonyms: Corticotropin Releasing Factor bovineCRF, bovine is a potent agonist of CRF receptor, and displaces [125I-Tyr]ovine CRF with a Ki of 3.52 nM.
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BMS-665053
0 ImagesCat. No.: HY-14132CAS No.: 1173435-64-7BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM).
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NBI 30545
0 ImagesCat. No.: HY-119247CAS No.: 195054-99-0NBI 30545 is a blood-brain barrier permeable CRF1R antagonist with a Ki value of 3.4 nM for the human receptor. NBI 30545 inhibits CRF-stimulated intracellular cAMP accumulation and ACTH release. NBI 30545 can be used in the research of depression, anxiety disorders and stress-related diseases.
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NGD 98-2 hydrochloride
0 ImagesCat. No.: HY-110310CAS No.: 1780390-58-0NGD 98-2 hydrochloride is an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist
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Mepixanox
0 ImagesCat. No.: HY-100150CAS No.: 17854-59-0Synonyms: PimexoneMepixanox (Pimexone) is an analeptic agent used in respiratory and cardiorespiratory insufficiency.
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E-2508 free base
0 ImagesCat. No.: HY-119114CAS No.: 685885-75-0E-2508 free base is an orally active and highly selective corticotropin-releasing factor type 1 receptor (CRF1) antagonist with anxiolytic effects (Ki=11 nM). E-2508 free base blocks CRF-induced cAMP accumulation via CRF1 receptor inhibition. E-2508 free base is promising for research of stress-related psychiatric disorders, such as anxiety and depression.
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BMS-763534
0 ImagesCat. No.: HY-120564CAS No.: 1188407-40-0BMS-763534 is a CRF1 antagonist that inhibits neurological disorders such as depression and anxiety..
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BMS-764459
0 ImagesCat. No.: HY-14225CAS No.: 1188407-45-5BMS-764459 is a CRF1 antagonist. BMS-764459 can be used for the research of neurological disorders such as depression and anxiety. BMS-764459 is also an atypical CYP1A1 inducer.
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a-Helical Corticotropin Releasing Factor (12-41)
0 ImagesCat. No.: HY-P3683CAS No.: 158535-55-8a-Helical Corticotropin Releasing Factor (12-41) is a 30 amino acids long, α-helical analogue of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, which stimulates the secretion of adrenocorticotrophic hormone (ACTH). a-Helical Corticotropin Releasing Factor (12-41) would suppress the stimulatory effect.
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Neuropeptide SF (human) acetate
0 ImagesCat. No.: HY-P1245ACAS No.: 2924824-03-1Synonyms: Neuropeptide NPFF (human) acetateNeuropeptide SF (human) acetate augments paraventricular corticotrophin-releasing hormone (CRH) release and increases adrenocorticotropic hormone (ACTH) and corticosterone levels in the plasma. Neuropeptide SF (human) acetate play a physiologic role in the regulation of such circadian functions as the activity of motor centers and the HPA axis, through the release of CRH.
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JNJ19567470
0 ImagesCat. No.: HY-107095CAS No.: 724471-26-5Synonyms: R317573; CRA5626; TAI041JNJ19567470 (R317573) is a selective, non-peptidergic CRF type 1 receptor (CRF1) antagonist. JNJ19567470 blocks NaLac-induced panic-like behaviour and cardiovascular responses. JNJ19567470 decreases regional glucose utilization in the amygdala, and attenuates anxiety responses.
