Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
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Calcium Channel Inhibitors
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Calcium Channel Agonists
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Calcium Channel Antagonists
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Calcium Channel Activators
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Calcium Channel Modulators
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Calcium Channel Chemical
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Calcium Channel Inducers
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Calcium Channel Controls
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Calcium Channel Ligands
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Calcium Channel Related Products (1247)
Related Products (1247)
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Antibodies (29)
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Related Compound Screening Libraries (1)
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Calcium Channel Isoform Comparison
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Mioflazine dihydrochloride
0 ImagesCat. No.: HY-U00049BCAS No.: 83898-67-3Mioflazine dihydrochloride is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride significantly improves cardiac survival after global cardiac ischemia. Mioflazine dihydrochloride reduces the mitochondrial calcium content in guinea-pig. Mioflazine dihydrochloride does not exhibit inotropic effects during induction and nursing.
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Naltiazem
0 ImagesCat. No.: HY-106810CAS No.: 108383-95-5Synonyms: Ro 23-6152Naltiazem (Ro 23-6152) is a thiazepinone-type calcium antagonist. Naltiazem inhibits platelet aggregation in vitro and in vivo.
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FURNIDIPINE
0 ImagesCat. No.: HY-16213CAS No.: 138661-03-7Synonyms: CRE 319FURNIDIPINE, an orally active cardio-protective agent, possesses anti-arrhythmic and antihypertensive effects.
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Phenchlobenpyrrone
0 ImagesCat. No.: HY-119492CAS No.: 215036-81-0Phenchlobenpyrrone is a highly selective neuronal calcium antagonist that crosses the blood-brain barrier. Phenchlobenpyrrone mildly inhibits AChE activity. Phenchlobenpyrrone inhibits Aβ aggregation and promotes the clearance of Aβ oligomers. Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. Phenchlobenpyrrone may be used in research on Alzheimer's disease.
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Iganidipine dihydrochloride
0 ImagesCat. No.: HY-101685ACAS No.: 117241-46-0Synonyms: NKY-722Iganidipine dihydrochloride is a Ca2+ antagonist.
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Nilvadipine-d4
0 ImagesCat. No.: HY-14284SCAS No.: 2928067-26-7Nilvadipine-d4 is deuterium labeled Nilvadipine. Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.
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BN 50341
0 ImagesCat. No.: HY-116400CAS No.: 107550-66-3BN 50341 is an orally active anticalcic agent and a benzazepine derivative. BN 50341 decreases the in vivo electrically induced thrombus formation in rat or guinea-pig artery and can be utilized in cardiovascular research.
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Drotaverine-d10 hydrochloride
0 ImagesCat. No.: HY-108974SDrotaverine-d10 (hydrochloride) is the deuterium labeled Drotaverine hydrochloride. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine hydrochloride exhibits in vivo antispasmodic efficacy without anticholinergic effects.
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AJ-3941
0 ImagesCat. No.: HY-165572CAS No.: 143110-70-7AJ-3941 is an orally active cerebrovascular-selective Calcium Channel antagonist having anti-lipid peroxidative action. AJ-3941 can ameliorate the brain infarction and edema after permanent focal cerebral ischemia.
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m-Nisoldipine
0 ImagesCat. No.: HY-W184837CAS No.: 113578-26-0Synonyms: KR-1008m-Nisoldipine (KR-1008) is a dihydropyridine calcium antagonist that can significantly increase cardiac output and heart index, significantly reduce the negative inotropic effect on the myocardium, and has a relatively high selectivity for the thoracic aorta. m-Nisoldipine can be used in the research of cardiovascular diseases.
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RQ-00311651
0 ImagesCat. No.: HY-118030CAS No.: 1257116-00-9RQ-00311651 is a T-type calcium channel blocker that specifically targets the Cav3.2 isoform with a role in neuropathic and visceral pain. RQ-00311651 significantly inhibits T currents in HEK293 cells expressing human Cav3.1 or Cav3.2. RQ-00311651 also inhibited high potassium-induced calcium signaling. RQ-00311651 also inhibits antiallergic properties in rats and mice with neuropathic pain induced by spinal nerve injury or Paclitaxel (HY-B0015). Oral and intraperitoneal injection (10-20 mg/kg) inhibits Cerulein (HY-A0190)-induced acute pancreatitis and cyclophosphamide-induced cystitis in mice.
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sFTX-3.3
0 ImagesCat. No.: HY-131942CAS No.: 141997-14-0sFTX-3.3 is a Ca2+ channel antagonist with IC50s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels.
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L-Phenylalanine-13C9,15N,d8
0 ImagesCat. No.: HY-N0215S9CAS No.: 1994331-22-4Synonyms: (S)-2-Amino-3-phenylpropionic acid-13C9,15N,d8L-Phenylalanine-13C9,15N,d8 is the deuterium, 13C-, and 15-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
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Amlodipine orotate
0 ImagesCat. No.: HY-B0317HCAS No.: 914941-70-1Amlodipine orotate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine orotate can be used for the research of high blood pressure and cancer.
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Norverapamil-d7 hydrochloride
0 ImagesSynonyms: (±)-Norverapamil-d7 hydrochloride; D591-d7 hydrochlorideNorverapamil-d7 (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
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Palonidipine hydrochloride
0 ImagesCat. No.: HY-108997ACAS No.: 96515-74-1Palonidipine hydrochloride is a calcium antagonist which is potential for the therapy of angina-pectoris and hypertension.
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Nifedipine-d4
0 ImagesCat. No.: HY-B0284S1CAS No.: 1219798-99-8Synonyms: BAY-a-1040-d4Nifedipine-d4 is the deuterium labeled Nifedipine. Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.
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PD 175069
0 ImagesCat. No.: HY-105365CAS No.: 217170-95-1PD 175069 is a potent and selective N-type calcium channel antagonist with an IC50 of 0.32 μM. PD 175069 is efficacious in an audiogenic seizure model using DBA/2 mice. PD 175069 can be used for research on neurological conditions such as neuropathic pain and stroke.
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Naltiazem hydrochloride
0 ImagesCat. No.: HY-106810ACAS No.: 108383-96-6Synonyms: Ro 23-6152 hydrochlorideNaltiazem (Ro 23-6152) hydrochloride is a thiazepinone-type calcium antagonist. Naltiazem hydrochloride inhibits platelet aggregation in vitro and in vivo.
