Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
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Calcium Channel Inhibitors
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Calcium Channel Agonists
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Calcium Channel Antagonists
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Calcium Channel Activators
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Calcium Channel Modulators
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Calcium Channel Chemical
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Calcium Channel Inducers
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Calcium Channel Controls
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Calcium Channel Ligands
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Calcium Channel Related Products (1247)
Related Products (1247)
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Antibodies (29)
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Related Compound Screening Libraries (1)
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Calcium Channel Isoform Comparison
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D-159404
0 ImagesCat. No.: HY-187591CAS No.: 1158221-32-9D-159404 is an orally active, blood-brain barrier-permeable, selective allosteric PDE4D inhibitor. It partially inhibits cAMP hydrolysis by binding to the UCR2 regulatory domain, elevates intracellular cAMP levels, and triggers calcium influx, thereby improving working memory and episodic memory consolidation. D-159404 is used in research on asthma, chronic obstructive pulmonary disease, and cognitive impairment.
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Efonidipine hydrochloride monoethanolate (Standard)
0 ImagesSynonyms: NZ-105 hydrochloride monoethanolate (Standard); (±)-Efonidipine hydrochloride monoethanolate (Standard)Efonidipine (NZ-105) hydrochloride monoethanolate (Standard) is the analytical standard of Efonidipine hydrochloride monoethanolate (HY-12502AR). This product is intended for research and analytical applications. Efonidipine (NZ-105) hydrochloride monoethanolate is an orally active dual L-type and T-type calcium channel blocker (CCB) with IC50 values of 1.8 and 350 nM, respectively. Efonidipine hydrochloride monoethanolate inhibits SARS-CoV-2 main protease. Efonidipine hydrochloride monoethanolate modulates adrenal steroidogenesis by increasing the expression of steroidogenic acute regulatory protein (StAR), dbcAMP-or angiotensin II-induced StAR mRNA expression and DHEA-S production, while suppressing the biosynthesis of aldosterone and cortisol. Efonidipine hydrochloride monoethanolate reduces plasma aldosterone levels in vivo. Efonidipine hydrochloride monoethanolate improves cardiac function in heart failure models by inhibiting T-type calcium channels (via both tonic and use-dependent blockade), independently of blood pressure reduction. Efonidipine hydrochloride monoethanolate can be used for research in hypertension, heart failure, and disorders involving dysregulated steroid hormone synthesis.
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o-3M3FBS (Standard)
0 ImagesCat. No.: HY-108608RCAS No.: 313981-55-4o-3M3FBS (Standard) is the analytical standard of o-3M3FBS (HY-108608). This product is intended for research and analytical applications. o-3M3FBS is the negative control of m-3M3FBS. o-3M3FBS inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner. In contrast, o-3M3FBS also causes an increase in [Ca2+]i in an agonistic manner.
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Dexnafenodone
0 ImagesCat. No.: HY-105521CAS No.: 92629-87-3Synonyms: (S)-Nafenodone free base; LU-43706 free baseDexnafenodone ((S)-Nafenodone free base; LU-43706 free base) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone inhibits the fast inward Na+ current and slow inward Ca2+ current in cardiomyocytes. Dexnafenodone inhibits voltage-gated and receptor-activated Ca2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca2+ stores, suppresses agonist-stimulated Ca2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone can be used in the research of depression.
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Lomerizine-d4
0 ImagesCat. No.: HY-B0768SLomerizine-d4 is the deuterium labeled Lomerizine (HY-B0768). Lomerizine is an antagonist of L- and T-type voltagegated calcium channels.
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Trimebutine maleate (Standard)
0 ImagesTrimebutine maleate (Standard) is the analytical standard of Trimebutine maleate (HY-B0380A). This product is intended for research and analytical applications. Trimebutine maleate is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine maleate inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine maleate also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine maleate also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine maleate also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).
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DHP-218
0 ImagesCat. No.: HY-106766CAS No.: 102097-78-9DHP-218 is a vasodilatory calcium antagonist with pronounced and long-lasting antihypertensive effects .
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JW480 (Standard)
0 ImagesCat. No.: HY-107582RCAS No.: 1354359-53-7
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(+)-Kavain (Standard)
0 Images(+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied.
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2-(tert-Butyl)-4,6-dimethylphenol
0 ImagesSynonyms: 6-tert-Butyl-2,4-xylenol2-(tert-Butyl)-4,6-dimethylphenol (6-tert-Butyl-2,4-xylenol) is an electrophilic alkylating agent, gasoline antioxidant and hydration substrate. 2-(tert-Butyl)-4,6-dimethylphenol inhibits SERCA activity in rabbit hindleg microsomes with an IC50 of 53 μM. Oxidation of 2-(tert-Butyl)-4,6-dimethylphenol generates the intermediate BDMP-QM, which covalently modifies nitrogen sites of proteins, polypeptides and free amino acids via Michael addition, triggering covalent modification of macromolecules and mediating cytotoxicity. 2-(tert-Butyl)-4,6-dimethylphenol is widely used in toxicological and biochemical studies of alkylphenols.
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Amlodipine (Standard)
0 ImagesAmlodipine (Standard) is the analytical standard of Amlodipine. This product is intended for research and analytical applications. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer.
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Saquinavir (Standard)
0 ImagesSynonyms: Ro 31-8959 (Standard)Saquinavir (Standard) (Ro 31-8959 (Standard)) is the analytical standard of Saquinavir (HY-17007). This product is intended for research and analytical applications. Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.
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FPL64176 (Standard)
0 ImagesCat. No.: HY-103307RCAS No.: 120934-96-5FPL64176 (Standard) is the analytical standard of FPL64176. This product is intended for research and analytical applications. FPL64176, a nondihydropyridine compound, is a potent agonist of L-type Ca2+ channels with an EC50 value of 16 nM.
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Falipamil
0 ImagesCat. No.: HY-106682CAS No.: 77862-92-1Synonyms: AQ-A 39Falipamil (AQ-A 39), a calcium channel blocker, is a bradycardic agent. The bradycardic effect results from a reduction in the diastolic depolarization rate and a prolongation of the action potential duration.
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GSK1016790A (Standard)
0 ImagesCat. No.: HY-19608RCAS No.: 942206-85-1GSK1016790A (Standard) is the analytical standard of GSK1016790A (HY-19608). This product is intended for research and analytical applications. GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells.
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D-myo-Inositol-3,4,5-triphosphate hexasodium
0 ImagesCat. No.: HY-181471CAS No.: 911105-38-9
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Tazanolast (Standard)
0 ImagesSynonyms: TO 188 (Standard); Tazalest (Standard); Tazanol (Standard)Tazanolast (Standard) (TO 188 (Standard)) is the analytical standard of Tazanolast (HY-101810). This product is intended for research and analytical applications. Tazanolast (TO 188) is an orally active selective mast cell stabilizer. Tazanolast prevents the elevation of intracellular calcium concentration, inhibits calcium uptake and Protein kinase C translocation, without directly inhibiting phospholipase C. Tazanolast inhibits ozone-induced airway hyperresponsiveness to Methacholine in guinea pigs, as well as passive cutaneous anaphylaxis, Schultz-Dale reaction, experimental asthma, passive cutaneous anaphylaxis in rats, and increased cutaneous vascular permeability in rats. Tazanolast does not alter airway responsiveness in sham-exposed guinea pigs, cell distribution in bronchoalveolar lavage fluid after ozone exposure, type II-IV allergic reactions, or histamine release from atopic leukocytes. Tazanolast can be used in research related to allergic diseases.
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SOICR-IN-1 (Standard)
0 ImagesCat. No.: HY-103059RCAS No.: 1479049-35-8SOICR-IN-1 (Standard) is the analytical standard of SOICR-IN-1 (HY-103059). This product is intended for research and analytical applications. SOICR-IN-1 (compound 32) is a store-overload induced calcium release (SOICR) inhibitor with an IC50 value of 14.6 μM. SOICR-IN-1 can be used for the research of cardiac arrhythmias.
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Calciseptine
0 ImagesCat. No.: HY-P3269CAS No.: 178805-91-9Calciseptine is a natural polypeptide toxin found in the venom of the black mamba snake (Dendroaspis p. polylepis). Calciseptine is a highly effective and selective blocker of the L-type channel of the Cav1.2 subtype, with an IC50 value of 92 nM. Calciseptine has no effect on Cav3.1, Cav2.2, Cav2.1, Cav1.1, voltage-sensitive sodium channels and potassium channels. Calciseptine exhibits negative inotropic and negative relaxant effects on mice, and does not affect heart rate or the action potential of sinoatrial node pacemaker cells. Calciseptine can be used for research on cardiovascular diseases[1].
