Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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3,4-Mdma tert-butyl carbamate
0 ImagesCat. No.: HY-139265CAS No.: 1228259-70-83,4-MDMA tert-butyl carbamate is a psychoactive compound.
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BH3I-2'
0 ImagesCat. No.: HY-121934CAS No.: 315195-18-7BH3I-2' is the BH3I-2 analogue. BH3I-2 is a Bcl-2 family inhibitor. BH3I-2' can be used for various studies.
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DT-678
0 ImagesCat. No.: HY-182012DT-678 is an orally active antiplatelet and antithrombotic inhibitor. DT-678 is a conjugate formed by linking the active metabolite of Clopidogrel (HY-15283) with 3-nitropyridine-2-thiol via a mixed disulfide bond. DT-678 does not rely on CYP2C19 for activation, and directly releases active substances via thiol exchange reactions in vivo, exhibiting superior efficacy over Clopidogrel. DT-678 can be used in research related to acute coronary syndrome and thrombosis.
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Gliamilide
0 ImagesCat. No.: HY-121307CAS No.: 51876-98-3Gliamilide is an active and well tolerated sulfamylurea derivative and displays a very short plasma half-life. Gliamilide is promising for research of maturity-onset diabetic deseases.
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Rhodomollein III
0 ImagesCat. No.: HY-N21745CAS No.: 142060-05-7Rhodomollein III is a grayanane-type tetracyclic diterpenoid found in the flowers of Rhododendron molle, the branches and leaves of Lyonia ovalifolia, and Pieris formosa, with a free OH group at the C (16) position.
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Ornithine-methotrexate
0 ImagesCat. No.: HY-115850CAS No.: 80407-73-4Ornithine-methotrexate is an active compound.
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Dibromochloroacetaldehyde
0 ImagesCat. No.: HY-133649CAS No.: 64316-11-6Dibromochloroacetaldehyde belongs to trihalogenated acetaldehyde and is a byproduct in drinking water. Dibromochloroacetaldehyde has genotoxicity.
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Physaminimin C
0 ImagesCat. No.: HY-N13789CAS No.: 1582259-03-7Physaminimin C is a natural steroid.
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Dodovisone A
0 ImagesCat. No.: HY-N16885CAS No.: 1616683-50-1Dodovisone A is a natural flavonoid.
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(3β,5α)-Androstan-3-amine hydrochloride
0 ImagesCat. No.: HY-122084CAS No.: 54156-23-9(3β,5α)-Androstan-3-amine (hydrochloride) is an active compound.
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3,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester
0 ImagesCat. No.: HY-N17534CAS No.: 409361-62-23,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester is a Caffeoylquinic acid derivative. 3,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester can be isolated from Aster tataricus. 3,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester does not inhibit LPS-induced nitric oxide production.
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Acoraminol A
0 ImagesCat. No.: HY-N15714CAS No.: 1342797-57-2Acoraminol A is one of the stereoisomers of phenylpropanoids, the other of which is Acoraminol B (HY-N15715), which can be isolated from the methanol extract of the rhizome of Acorus tatarinowii. Acoraminol A has weak cytotoxic effects on several human tumor cell lines (IC50>30 μM).
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ZIMET 124/73
0 ImagesCat. No.: HY-123168CAS No.: 61930-46-9ZIMET 124/73 is a hetarylhydrazone derivative. ZIMET 124/73 is a potent antiviral agent. ZIMET 124/73 can be used for Mengo virus research.
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Isoxepac-d6
0 ImagesCat. No.: HY-W050088SCAS No.: 2012598-71-7Synonyms: HP 549-d6Isoxepac-d6 (HP 549-d6) is the deuterium labeled Isoxepac (HY-W050088). Isoxepac (HP 549) is an orally active non-steroidal anti-inflammatory agent. Isoxepac can inhibit Carrageenan (HY-125474) paw oedema, adjuvant-induced polyarthritis, and prostaglandin synthesis. Isoxepac (200 mg) has an analgesic effect after meniscectomy with a low incidence of side effects. Isoxepac can be used in the research of inflammatory (rheumatoid arthritis) and pain-related diseases.
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Homofukinolide
0 ImagesCat. No.: HY-N21780CAS No.: 41059-96-5Homofukinolide is a bakkenolide-type sesquiterpenoid found in the rhizomes of Petasites tatewakianus Kitam and can serve as a marker for plant quality evaluation.
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Methyl cis-15-tetracosenoate
0 ImagesSynonyms: Methyl nervonate; Methyl (Z)-tetracos-15-enoate; Nervonic acid methyl esteMethyl cis-15-tetracosenoate (Methyl nervonate; Methyl (Z)-tetracos-15-enoate; Nervonic acid methyl ester) is the methyl ester form of nervonic acid (Nervonic acid, HY-N2526). Nervonic acid is an orally active monounsaturated fatty acid. Nervonic acid exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. Nervonic acid can be used in the research of neurodegenerative diseases.
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(+)-Epinortrachelogenin
0 ImagesCat. No.: HY-N10909CAS No.: 124988-62-1(+)-Epinortrachelogenin is a natural lignan.
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DL-Methionine Sulfone
0 ImagesCat. No.: HY-W141863CAS No.: 820-10-0DL-Methionine Sulfone is a Methionine (HY-13694) derivative.
