Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Controls
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Drug Derivative Related Products (4056)
Related Products (4056)
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1,8-Dihydroxy-p-menth-3-en-2-one
0 ImagesCat. No.: HY-N16951CAS No.: 1392224-56-41,8-Dihydroxy-p-menth-3-en-2-one is a natural terpenoid.
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NPC 573
0 ImagesCat. No.: HY-129266CAS No.: 119953-19-4NPC 573 is a Bradykinin (HY-P0206) analog. NPC 573 inhibits contraction of the uterus.
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Visartiside E
0 ImagesCat. No.: HY-N13775CAS No.: 1212005-08-7Visartiside E is a natural phenolic compound.
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5α-4,5-Dihydroscillaren A
0 ImagesCat. No.: HY-N19798CAS No.: 131221-53-95α-4,5-Dihydroscillaren A is a bufadienolide that can be found in the bulbs of Urginea sanguinea.
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LAS 30538
0 ImagesCat. No.: HY-116109CAS No.: 145067-04-5LAS 30538 is an active compound.
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Steppogenin-5'-C-β-D-glucopyranoside
0 ImagesCat. No.: HY-N16844CAS No.: 2082826-38-6Steppogenin-5'-C-β-D-glucopyranoside is a natural flavonoid.
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3β-(4-Hydroxybenzoyloxy)-21β,29-dihydroxyserrat-14-en-24-oic acid
0 ImagesCat. No.: HY-N17064CAS No.: 1217268-13-73β-(4-Hydroxybenzoyloxy)-21β,29-dihydroxyserrat-14-en-24-oic acid is a natural triterpene.
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Wilfordeuphone
0 ImagesCat. No.: HY-N17068CAS No.: 2721399-33-1Wilfordeuphone is a natural triterpene.
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WO677
0 ImagesCat. No.: HY-187835CAS No.: 3088105-77-2WO677 is a KCNT1 inhibitor that can be used in studies of nervous system disorders associated with KCNT1 function, such as epilepsy.
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Salicyloylsalicin
0 ImagesCat. No.: HY-N17577CAS No.: 27968-78-1Salicyloylsalicin is a salicylic acid glycoside natural product present in the bark of Populus balsamifera.
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Antitumor agent-208
0 ImagesCat. No.: HY-180430CAS No.: 1385011-94-8Antitumor agent-208, a Bufalin (HY-N0877) analogue, is a potent and orally active antitumor agent. Antitumor agent-208 exhibits antiproliferative activity against tumor cell line (IC50 =0.30-1.09 nM). Antitumor agent-208 inhibits tumor growth in a MV-4-11 xenograft mouse model. Antitumor agent-208 can be used for cancer research, such as acute myeloid leukemia (AML) and non-small cell lung cancer (NSCLC).
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Juncuenin A
0 ImagesCat. No.: HY-N9771CAS No.: 1161681-18-0Juncuenin A is a natural phenolic compound.
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12-Deoxyphorbol-13-isobutyrate-20-acetate
0 ImagesCat. No.: HY-N18070CAS No.: 25090-71-512-Deoxyphorbol-13-isobutyrate-20-acetate is a 12-deoxy-phorbol diterpene ester. 12-Deoxyphorbol-13-isobutyrate-20-acetate is a protein kinase C (PKC) agonist that activates protein kinase C to phosphorylate troponin I and troponin T. 12-Deoxyphorbol-13-isobutyrate-20-acetate induces skin irritation and necrosis in mice without cocarcinogenic activity. 12-Deoxyphorbol-13-isobutyrate-20-acetate inhibits Aspergillus carbonarius growth. 12-Deoxyphorbol-13-isobutyrate-20-acetate supports research on heart failure, cardiomyopathies and fungal infection.
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Re 80
0 ImagesCat. No.: HY-118239CAS No.: 116193-60-3Re 80 is an anti-angiogenic agent and is a synthetic retinoid.
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MTAAAR
0 ImagesCat. No.: HY-P12337MTAAAR is a polypeptide obtained from the enzymatic hydrolysis of C-phycocyanin (HY-D1025) and possesses neuroprotective activity. MTAAAR enhances the activities of antioxidant enzymes SOD, CAT, and GSH-Px, reduces ROS, inhibits apoptosis and acetylcholinesterase (AChE) activity in brain tissue, and decreases protein carbonyl content. In the MPTP (HY-W114750)-induced zebrafish Parkinson's disease model, MTAAAR exhibits antioxidant effects, inhibits autophagy and apoptosis, reverses the loss of dopaminergic neurons and cerebral blood vessels, and alleviates motor deficits. MTAAAR can be used for research on Parkinson's disease.
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Antifibrotic agent 2
0 ImagesCat. No.: HY-177739CAS No.: 1590409-23-6Antifibrotic agent 2 (Compound 636) is a polycyclic pyridinone derivative with antifibrotic activity. Antifibrotic agent 2 reduces the pathological accumulation of fibrosis-related proteins such as fibronectin and collagen, prevents excessive fibrous connective tissue from depositing in organs or tissues, and reverses or delays the remodeling of tissue fibrosisby regulating the abnormal proliferation and activation of fibroblasts. Antifibrotic agent 2 can be used for research on pulmonary fibrosis.
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Isosativanone
0 ImagesCat. No.: HY-N13741CAS No.: 82829-55-8Isosativanone is a natural flavonoid.
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WAY-629450
0 Images3,3,9-Trimethyl-3,4-dihydroacridin-1(2H)-one is an active molecule.
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TG3-95-1
0 ImagesCat. No.: HY-116845CAS No.: 301322-12-3TG3-95-1 is an active compound.
