Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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Antifibrotic agent 2
0 ImagesCat. No.: HY-177739CAS No.: 1590409-23-6Antifibrotic agent 2 (Compound 636) is a polycyclic pyridinone derivative with antifibrotic activity. Antifibrotic agent 2 reduces the pathological accumulation of fibrosis-related proteins such as fibronectin and collagen, prevents excessive fibrous connective tissue from depositing in organs or tissues, and reverses or delays the remodeling of tissue fibrosisby regulating the abnormal proliferation and activation of fibroblasts. Antifibrotic agent 2 can be used for research on pulmonary fibrosis.
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Isosativanone
0 ImagesCat. No.: HY-N13741CAS No.: 82829-55-8Isosativanone is a natural flavonoid.
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WAY-629450
0 Images3,3,9-Trimethyl-3,4-dihydroacridin-1(2H)-one is an active molecule.
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TG3-95-1
0 ImagesCat. No.: HY-116845CAS No.: 301322-12-3TG3-95-1 is an active compound.
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6-Methoxyspirotryprostatin B
0 ImagesCat. No.: HY-N7735CAS No.: 1031727-28-26-Methoxyspirotryprostatin B is a natural alkaloid.
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Blapsin B
0 ImagesCat. No.: HY-N19296CAS No.: 861145-00-8Blapsin B is a potent 14-3-3 inhibitor and a naturally occurring compound from Blaps japanensis. Blapsin B potently inhibits 14-3-3 protein-protein interactions (PPIs) with an IC50 value of 10.0 μM in the ELISA assay and 2.5 μM in the FP assay, respectively. Blapsin B modulates signaling pathways involved in cell proliferation and transformation. Blapsin B can be used for cancer research.
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Ligustilidiol
0 ImagesCat. No.: HY-N17482CAS No.: 88551-87-5Ligustilidiol is a natural product that can be found in Chuanxiong.
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β-Glucosyl indole-3-carboxylate
0 ImagesCat. No.: HY-N13735CAS No.: 106871-55-0β-Glucosyl indole-3-carboxylate is a natural alkaloid.
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1-O-Methylclausenolide
0 ImagesCat. No.: HY-N16845CAS No.: 148763-15-91-O-Methylclausenolide is a natural triterpene.
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Siagoside
0 ImagesCat. No.: HY-106366CAS No.: 100345-64-0Siagoside is an inner ester of Ganglioside GM1 (HY-N10546). Siagoside selectively attenuates morphological and functional striatal impairments induced by transient forebrain ischemia in rats. Siagoside can be used for the research of neurological disease, such as acute cerebral ischemia.
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Suffruticosol C
0 ImagesCat. No.: HY-N17094CAS No.: 220936-94-7Suffruticosol C is a natural phenolic compound.
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BO-653
0 ImagesCat. No.: HY-182603CAS No.: 157360-23-1BO-653 is an orally active anti-atherosclerotic antioxidant that exhibits high binding affinity for LDL. BO-653 scavenges linoleic acid peroxyl radicals, inhibits lipid peroxidation during the auto-oxidation of linoleic acid, and potently suppresses LDL oxidation. BO-653 inhibits Hepatitis C Virus (HCV) replication in a concentration-dependent manner, with an IC50 of 36.0 μM against the HCV subgenomic replicon in FLR3-1 cells. BO-653 demonstrates significant anti-atherosclerotic effects in various animal models, including the Watanabe heritable hyperlipidemic rabbit. BO-653 is suitable for use in research related to atherosclerosis and Hepatitis C Virus infection.
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N-Cholyl-L-glutamic acid
0 ImagesCat. No.: HY-176967CAS No.: 23828-78-6Synonyms: GluCAN-Cholyl-L-glutamic acid (GluCA) is a Cholic acid (HY-N0324) conjugated with L-glutamic acid (HY-14608). N-Cholyl-L-glutamic acid increases expression of PXR and downstream PXR-target gene Cyp3a11. N-Cholyl-L-glutamic acid can be used in the research of Crohn's disease.
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Neuroprotective agent 1
0 ImagesCat. No.: HY-149094CAS No.: 2344786-13-4Neuroprotective agent 1 (2), a promising neuroprotective agent for the study of ischemic stroke, shows promising neuroprotective activity with the EC50 value of 16.07 μM in the model of glutamate-induced excitotoxicity and 19.30 μM in the model of H2O2-induced oxidative damage.
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Yunnancoronarin B
0 ImagesCat. No.: HY-N16806CAS No.: 162762-94-9Yunnancoronarin B is a natural diterpene.
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Cimiside A
0 ImagesCat. No.: HY-N18122CAS No.: 152685-90-0Cimiside A is a 9,19-cycloartane triterpene monoglycoside.Cimiside A can be found in the rhizome of Cimicifuga foetida.
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Pyridylpaeoniflorin
0 ImagesCat. No.: HY-N17052CAS No.: 1427054-19-0Pyridylpaeoniflorin is a natural terpenoid.
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(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol
0 ImagesCat. No.: HY-N17401CAS No.: 71097-07-9(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol is a natural product that can be found in Claviceps purpurea.
