EGFR
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EGFR Ligands
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EGFR Related Products (757)
Related Products (757)
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Neratinib-d6
0 ImagesCat. No.: HY-32721SCAS No.: 1259519-18-0Neratinib-d6 (HKI-272-d6) is the deuterium labeled Neratinib. Neratinib (HKI-272) is an orally available, irreversible tyrosine kinase inhibitor with IC50s of 59 nM and 92 nM for HER2 and EGFR, respectively.
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NSC 104999
0 ImagesCat. No.: HY-180480CAS No.: 1118745-14-4NSC 104999 is a Grb7 SH2 domain binder with moderate affinity (Kd = 32.3 μM). NSC 104999 exhibits anticancer activity against breast cancer.
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Dacomitinib (Standard)
0 ImagesSynonyms: PF-00299804 (Standard); PF-299804 (Standard)Dacomitinib (Standard) is the analytical standard of Dacomitinib. This product is intended for research and analytical applications. Dacomitinib (PF-00299804) is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
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Canertinib (Standard)
0 ImagesSynonyms: CI-1033 (Standard); PD-183805 (Standard)Canertinib (Standard) is the analytical standard of Canertinib. This product is intended for research and analytical applications. Canertinib (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib is active against vaccinia virus respiratory infection in mice.
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Rociletinib hydrobromide (Standard)
0 ImagesSynonyms: CO-1686 hydrobromide (Standard); AVL-301 hydrobromide (Standard); CNX-419 hydrobromide (Standard)Rociletinib hydrobromide (Standard) is the analytical standard of Rociletinib hydrobromide. This product is intended for research and analytical applications. Rociletinib hydrobromide (CO-1686 hydrobromide) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.
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AKOS024836912
0 ImagesCat. No.: HY-137081CAS No.: 1705763-81-0AKOS024836912 is a EGFR-EGF interaction inhibitor. AKOS024836912 is applicable to research related to non-small cell lung cancer.
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Icotinib (Standard)
0 ImagesCat. No.: HY-15164ARCAS No.: 610798-31-7Synonyms: BPI-2009 (Standard)Icotinib (Standard) is the analytical standard of Icotinib. This product is intended for research and analytical applications. Icotinib (BPI-2009) is a potent and specific EGFR inhibitor with an IC50 of 5 nM; also inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M and EGFRL861Q. Icotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Tyrphostin 23 (Standard)
0 ImagesCat. No.: HY-15644RCAS No.: 118409-57-7Synonyms: Tyrphostin A23 (Standard); RG-50810 (Standard); AG 18 (Standard)Tyrphostin 23 (Standard) is the analytical standard of Tyrphostin 23. This product is intended for research and analytical applications. Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively.
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Eucommin A
0 ImagesCat. No.: HY-N20729CAS No.: 99633-12-2Eucommin A is a natural polyphenolic antioxidant. Eucommin A forms stable complexes with EGFR and MAPK8 via hydrogen bonding and hydrophobic interactions, and regulates osteoarthritis-related Autophagy. Eucommin A is applicable to research related to oxidative stress, such as osteoarthritis.
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Paeciloquinone C
0 ImagesCat. No.: HY-N14637CAS No.: 92439-42-4Paeciloquinone C can inhibit the EGFR protein tyrosine kinase. Paeciloquinone C inhibits the V-abl protein tyrosine Kinase with an IC50 of 0.56 μM.
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MTX-211 (Standard)
0 ImagesCat. No.: HY-107364RCAS No.: 1952236-05-3Synonyms: Mol 211 (Standard)MTX-211 (Standard) (Mol 211 (Standard)) is the analytical standard of MTX-211 (HY-107364). This product is intended for research and analytical applications. MTX-211 (Mol 211) is a dual inhibitor of EGFR and PI3K with IC50 values of ＜100 nM. MTX-211 can be used for the research of cancer and other diseases.
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TX1-85-1 (Standard)
0 ImagesCat. No.: HY-100848RCAS No.: 1603845-32-4TX1-85-1 (Standard) is the analytical standard of TX1-85-1 (HY-100848). This product is intended for research and analytical applications. TX1-85-1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling.
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1,2,3,4-Tetrahydro Staurosporin
0 ImagesCat. No.: HY-W740378CAS No.: 220038-19-7Synonyms: AFN-9411,2,3,4-Tetrahydrostaurosporine is a derivative of Staurosporine (HY-15141) and an inhibitor of mutant EGFR (IC50=74 nM for EGFRT790M). It is selective for EGFRT790M over wild-type EGFR (IC50=390 nM). It also binds to Janus kinase 3 (JAK3).
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Rezivertinib (Standard)
0 ImagesCat. No.: HY-109189RCAS No.: 1835667-12-3Synonyms: BPI-7711 (Standard)Rezivertinib (Standard) is the analytical standard of Rezivertinib (HY-109189). This product is intended for research and analytical applications. Rezivertinib (BPI-7711) is an orally active, highly selective and irreversible third-generation EGFR tyrosine Kinase inhibitor (TKi). Rezivertinib exhibits high potency against the common activation EGFR and the resistance T790M mutations. Rezivertinib has excellent central nervous system (CNS) penetration and has antitumor activity.
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Pelitinib (Standard)
0 ImagesSynonyms: EKB-569 (Standard); WAY-EKB 569 (Standard)Pelitinib (Standard) is the analytical standard of Pelitinib. This product is intended for research and analytical applications. Pelitinib (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively.
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HKI-357 (Standard)
0 ImagesCat. No.: HY-103443RCAS No.: 848133-17-5HKI-357 (Standard) is the analytical standard of HKI-357 (HY-103443). This product is intended for research and analytical applications. HKI-357 is an irreversible dual inhibitor of EGFR and ERBB2 with IC50s of 34 nM and 33 nM, respectively. HKI-357 suppresses EGFR autophosphorylation (at Y1068), and AKT and MAPK phosphorylation.
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BMS-690514 (Standard)
0 ImagesCat. No.: HY-10333RCAS No.: 859853-30-8BMS-690514 (Standard) is the analytical standard of BMS-690514 (HY-10333). This product is intended for research and analytical applications. BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR; has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.
