Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2768)
Related Products (2768)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Nidulin
0 ImagesCat. No.: HY-135422CAS No.: 10089-10-8Synonyms: MethylustinNidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candida albicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp.
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Eupenoxide
0 ImagesCat. No.: HY-N15024CAS No.: 89773-19-3Eupenoxide is an antibiotic with antifungal activity that can be found by fungi of the genus Eupenicillium.
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Cyclosporin L
0 ImagesCat. No.: HY-N9754CAS No.: 108027-39-0Cyclosporin L is a cyclosporin that can be found in Tolypocladium inflatum, with moderate immunosuppressive and antifungal activities.
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2,6-Dibromophenol (Standard)
0 Images2,6-Dibromophenol (2,6-DBP) is a weak inhibitor targeting voltage-gated Ca2+ channels. 2,6-Dibromophenol has no significant effect on potassium-induced calcium elevation in PC12 cells. 2,6-Dibromophenol shows a 48 h EC50 of 2.78 mg/L for Daphnia magna and a 96 h EC50 of 9.90 mg/L for algae (Scenedesmus quadricauda).
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Pseudolaric Acid C (Standard)
0 ImagesCat. No.: HY-N0672RCAS No.: 82601-41-0Pseudolaric Acid C (Standard) is the analytical standard of Pseudolaric Acid C. This product is intended for research and analytical applications. Pseudolaric C is a diterpenoid isolated from the root bark of Pseudolarix amabilis, has antifungal activity.
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Erigeside II
0 ImagesCat. No.: HY-N10318CAS No.: 100187-70-0Synonyms: Dictamnoside AErigeside II is a sesquiterpene glycoside found in the root bark of Dictamnus dasycarpus. Erigeside II stimulates the proliferation of T-cells.
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2-Chloro-N-(2-methyl-4-bromophenyl)acetamide
0 ImagesCat. No.: HY-101424CAS No.: 96686-51-02-Chloro-N-(2-methyl-4-bromophenyl)acetamide is an antifungal compound.
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CYP51-IN-30
0 ImagesCat. No.: HY-179270CAS No.: 108590-84-7
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Nuarimol
0 ImagesCat. No.: HY-W714300CAS No.: 63284-71-9Nuarimol is a fungicide used for plant protection in agriculture. Nuarimol is a phenobarbital-type inducer of hepatic drug-metabolizing enzymes. It triggers transient but robust regenerative hepatocyte proliferation accompanied by hepatomegaly by causing reversible hepatocellular injury.
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Appenolide A
0 ImagesCat. No.: HY-125487CAS No.: 148077-10-5Appenolide A is an antifungal furanones that can be isolated from the coprophilous fungus Podospora appendiculata.
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β-Prumycin hydrochloride
0 ImagesCat. No.: HY-N14912CAS No.: 54612-74-7β-Prumycin hydrochloride is a carbohydrate antibiotic. β-Prumycin hydrochloride has anti-fungal activity and weak anti-individual bacterial activity.
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Oomycete-IN-1
0 ImagesCat. No.: HY-175038CAS No.: 2945180-71-0Oomycete-IN-1 (Compound X4) is a selective inhibitor targeting the PH domain of PcORP1 in Phytophthora species. Oomycete-IN-1 shows EC50 values ranging from 1 to 4 μg/mL against six oomycetes. Oomycete-IN-1 disrupts lipid transport and metabolism, leading to mycelium hyperplasia and cell membrane ruffling in P. capsici. Oomycete-IN-1 can be used in the research of preventing and controlling oomycete diseases (such as P. capsici infection).
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5,7-Dihydroxy-4-methylcoumarin (Standard)
0 Images5,7-Dihydroxy-4-methylcoumarin (Standard) is the analytical standard of 5,7-Dihydroxy-4-methylcoumarin. This product is intended for research and analytical applications. 5,7-Dihydroxy-4-methylcoumarin is a coumarin derivative from Mexican tarragon. 5,7-Dihydroxy-4-methylcoumarin possesses antifungal and antibacterial activities.
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Antimicrobial agent-42
0 ImagesCat. No.: HY-175699Antimicrobial agent-42 (Compound 6j) is an antimicrobial agent. Antimicrobial agent-42 interacts with key amino acids such as Lys59 and Ser170 within the ALS3 protein, crucial for the binding of host peptides. Antimicrobial agent-42 significantly inhibits Candida albicans biofilm formation and reduces planktonic cells aggregation and hyphal formation. Antimicrobial agent-42 has an antifungal activity, promising for fungal infections reseach.
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CYP51-IN-2
0 ImagesCat. No.: HY-136752CAS No.: 1155361-00-4CYP51-IN-2 (compound 1b), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows 64 and 128 times higher activity than that of Fluconazole against Microsporum gypseum and Candida albicans, respectively.
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Rhizocticin A
0 ImagesCat. No.: HY-126770CAS No.: 114301-25-6Rhizocticin A is a natural antifungal phosphonate oligopeptide produced by Bacillus subtilis ATCC 6633 that targets threonine synthase (TS). Rhizocticin A enters sensitive fungal cells via oligopeptide transport systems and releases its active (S,Z)-APPA moiety through hydrolysis by intracellular peptidases. Rhizocticin A exhibits antifungal activity against yeasts and filamentous fungi, with a MIC of 0.35 μg/mL against Saccharomyces cerevisiae, Saccharomycopsis lipolytica and Schizosaccharomyces pombe. Rhizocticin A can be used in studies related to fungal infections, oligopeptide transport and threonine biosynthesis.
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Leucomycin A5
0 ImagesCat. No.: HY-125569CAS No.: 18361-45-0Leucomycin A5 has antifungal activity, with the MIC for Staphylococcus pyogenes pen S, Staphylococcus pyogenes pen R, and Staphylococcus faecalis being 0.8, 3.2, and 0.8 μg/mL, respectively.
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3-Amino-1,2,4-triazin-5(2H)-one
0 ImagesCat. No.: HY-W167979CAS No.: 1121-90-03-Amino-1,2,4-triazin-5(2H)-one is an organic compound belonging to the triazine family. 3-Amino-1,2, 4-Triazin-5 (2H)-one and its derivatives may have a variety of biological activities, such as antibacterial, antifungal, antiviral, or antitumor but the specific activity depends on its chemical structure and functional groups. 3-Amino-1,2, 4-Triazin-5 (2H)-one is a lead compound with a wide range of applications.
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Albiducin A
0 ImagesCat. No.: HY-N15343CAS No.: 2222286-14-6Albiducin A is an antibiotic found in Hymenoscyphus albidus, exhibiting antibacterial and anticancer activities. The MIC range of Albiducin A against bacteria and fungi is 16.7-66.7 mg/mL. Its IC50 values for mouse fibroblast cell line (L929) and human cervical carcinoma cell line (KB3-1) are 6.1 and 2.7 μg/mL, respectively. Albiducin A holds promise for research in the fields of infection and cancer diseases.
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Iprovalicarb
0 ImagesCat. No.: HY-121766CAS No.: 140923-17-7Synonyms: Fencaramid; SZX-0722Iprovalicarb (Fencaramid; SZX-0722) is a fungicide that can be used for the study of fungal diseases in the wine sector.
