Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
-
Fungal Related Products (2753)
Related Products (2753)
-
Antibodies (1)
-
Related Compound Screening Libraries (1)
-
N-Decyl-N,N-dimethyldecan-1-aminium-d6 chloride
0 ImagesCat. No.: HY-W042181SSynonyms: Didecyldimethylammonium-d6 chloride; DDAC-d6N-Decyl-N,N-dimethyldecan-1-aminium-d6 (chloride) is a deuterated labeled N-Decyl-N,N-dimethyldecan-1-aminium (chloride). N-Decyl-N,N-dimethyldecan-1-aminium chloride (Didecyldimethylammonium chloride) is a dialkyl-quaternary ammonium compound that is used in numerous products for its bactericidal, virucidal and fungicidal properties.
-
Phomalactone
0 ImagesCat. No.: HY-N10269CAS No.: 28921-94-0Phomalactone, produced by the fungus Nigrospora sphaerica, specifically inhibits the mycelial growth of Phytophthora infestans, with an MIC value of 2.5 mg/L. Phomalactone is phytotoxic to Z. elegans and other plant species by inhibition of seedling growth and by causing electrolyte leakage from photosynthetic tissues of both Z. elegans leaves and cucumber cotyledons.
-
Antifungal agent 177
0 ImagesCat. No.: HY-N21986CAS No.: 1096965-33-1Antifungal agent 177 is a novel steroidal saponin found in the rhizomes of Paris polyphylla Smith. Antifungal agent 177 exhibits antifungal activity against Cladosporium cladosporioides, with a liquid MIC of 50 μg/mL against Candida albicans. Antifungal agent 177 is applicable to research related to fungal infections.
-
β-Cedrene
0 Imagesβ-Cedrene ((+)-β-Cedrene) is a sesquiterpene compound that can be isolated from Centaurea kotschyi var. kotschyi and Centaurea kotschyi var. decumbens, exhibiting antibacterial, anti-inflammatory, antispasmodic, tonic, diuretic, sedative, insecticidal, and antifungal activities. β-Cedrene is also a potent competitive inhibitor of the CYP2B6-mediatedbupropion hydroxylase, with a Ki value of 1.6 μM.
-
Antifungal agent 121
0 ImagesCat. No.: HY-169252CAS No.: 343362-45-8Antifungal agent 121 (compound TM11) is a fungicide. The chemical nature of Antifungal agent 121 is a benzimidazole-acrylonitrile derivative.
-
SDH-IN-18
0 ImagesCat. No.: HY-159486CAS No.: 723748-50-3SDH-IN-18 (Compound 3a) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 8.70 mg/L. SDH-IN-18 destroys fungal morphology and reproduction, exhibits antifungal activity against Rhizoctonia solani and Sclerotinia sclerotiorum with EC50 of 0.48 and 1.4 mg/L.
-
VEGFR-2/DHFR-IN-2
0 ImagesCat. No.: HY-151459CAS No.: 2831498-09-8VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer.
-
Isobellidifolin
0 ImagesIsobellidifolin, a xanthone, is a free radical scavenger and antioxidant compound. Isobellidifolin has potent antifungal effect.
-
Alterlactone
0 ImagesCat. No.: HY-N9068CAS No.: 1030376-89-6
-
Antifungal agent 60
0 ImagesCat. No.: HY-155545Antifungal agent 60 (compound 16) is an inhibitor of ergosterol biosynthesis with broad-spectrum antifungal activity. Antifungal agent 60 inhibits 7 human pathogenic fungal species, 2 fluconazole-resistant C. albicans isolates and 2 multi-drug resistant Candida auris isolates. Antifungal agent 60 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
(+)-Aureol
0 ImagesCat. No.: HY-N20663CAS No.: 72853-81-7(+)-Aureol is a tetracyclic benzopyran-fused decalin-type 9-norspongiane heteroterpenoid. (+)-Aureol exhibits antifungal activity, with an EC50 value of 6.9 μM against Rhizoctonia solani and an EC50 value of 19 μM against Sclerotinia sclerotiorum. (+)-Aureol shows selective inhibitory activity against human tumor cells. (+)-Aureol acts as an anti-influenza agent with activity against influenza A virus. (+)-Aureol can be used in research related to fungal infections, non-small cell lung cancer, colon adenocarcinoma and influenza A virus infections.
-
Succinate dehydrogenase-IN-1
0 ImagesCat. No.: HY-162648CAS No.: 2969128-94-5Succinate dehydrogenase-IN-1 (Compound 34) is an inhibitor for succinate dehydrogenase (SDH) with an IC50 of 0.94 μM and a KD of 22.4 μM. Succinate dehydrogenase-IN-1 exhibits antifungal activity against Rhizoctonia solani, Sclerotinia sclerotiorum, Monilinia fructicola, and Botrytis cinerea, with EC50 of 0.04 μM, 1.13 μM, 1.61 μM and 1.21 μM, respectively.
-
Mollicellin K
0 ImagesCat. No.: HY-178724CAS No.: 1179374-63-0Mollicellin K is a depsidone that can be isolated from the fungus Chaetomium brasiliense. Mollicellin K exhibits antimicrobial activity against Myobacterium tuberculosis, antimalarial activity (IC50 = 1.2 μM) against Plasmodium falciparum as well as antifungal property (IC50 = 1.2 μM) against Candida albicans. Mollicellin K is cytotoxic against KB (IC50 = 1.9 μM), BC1 (IC50 = 6.8 μM), NCI-H187 (IC50 = 0.35 μM), and five cholangiocarcinoma cell lines. Mollicellin K also has an MIC of 12.5 μM for tuberculosis.
-
Benodanil (Standard)
0 ImagesCat. No.: HY-108422RCAS No.: 15310-01-7Synonyms: NSC 100499 (Standard); BAS 3170F (Standard)Benodanil (Standard) is the analytical standard of Benodanil. This product is intended for research and analytical applications. Benodanil (NSC 100499) is a group of benzanilide fungicide, is used extensively in agriculture.
-
P163-0892
0 ImagesCat. No.: HY-150972CAS No.: 1574576-45-6P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium BBB penetration.
-
Sortin2
0 ImagesCat. No.: HY-122245CAS No.: 372972-39-9Sortin2 is a synthetic compound and a Yeast vacuolar protein sorting (vps) inhibitor . Sortin2 can affect protein targeting to the vacuole in Saccharomyces cerevisiae.
-
Dimethomorph-d8
0 ImagesCat. No.: HY-B0846SCAS No.: 1346606-71-0Dimethomorph-d8 is the deuterium labeled Dimethomorph. Dimethomorph is a fungicide belongs to the fungicide group of sterol biosynthesis inhibitor. Dimethomorph can inhibit fungal cell wall formation. Dimethomorph also inhibits androgen receptor (AR) activity in MDA-kb2 cells with an IC20 of 0.263 μM.
-
Pterolactam
0 ImagesCat. No.: HY-N1567CAS No.: 38072-88-7Pterolactam can be isolated from Chrysanthemum coronarium L. Pterolactam derivates serval analogues that Mannich bases of amide with antifungal activities and cytotoxicity.
-
F2928-1
0 ImagesCat. No.: HY-N19242CAS No.: 877060-85-0F2928-1 is a small-molecule polyketide antifungal antibiotic. F2928-1 can kill harmful fungi such as Aspergillus fumigatus. F2928-1 can be used in studies related to aspergillosis and candidiasis.
-
8-Acetonyldihydronitidine
0 ImagesCat. No.: HY-N21597CAS No.: 80330-39-88‑Acetonyldihydronitidine is a naturally occurring benzophenanthridine alkaloid with antibacterial, antifungal, and anti-proliferative activities against colorectal cancer cells. 8‑Acetonyldihydronitidine inhibits Staphylococcus aureus and exerts a potent antifungal effect against Cladosporium cladosporioides. 8‑Acetonyldihydronitidine activates the p53 signaling pathway, upregulates the expression of target genes including p21, BAX, and FAS, downregulates cyclin A and cyclin B, and induces cell cycle arrest and apoptosis, thereby suppressing the proliferation of colorectal cancer cells. 8‑Acetonyldihydronitidine is used in research related to colorectal cancer, fungal infections, and bacterial infections.
