(+)-Aureol
(+)-Aureol is a tetracyclic benzopyran-fused decalin-type 9-norspongiane heteroterpenoid. (+)-Aureol exhibits antifungal activity, with an EC50 value of 6.9 μM against Rhizoctonia solani and an EC50 value of 19 μM against Sclerotinia sclerotiorum. (+)-Aureol shows selective inhibitory activity against human tumor cells. (+)-Aureol acts as an anti-influenza agent with activity against influenza A virus. (+)-Aureol can be used in research related to fungal infections, non-small cell lung cancer, colon adenocarcinoma and influenza A virus infections.
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- CAS. Nr.: 72853-81-7
- Formel: C21H30O2
- Molecular Weight:314.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
(+)-Aureol (compound 22) (0.78125-50 μg/mL; fungal growth period) potently inhibits the growth of Rhizoctonia solani with an EC50 of 6.9 μM[1].
(+)-Aureol (0.78125-50 μg/mL; fungal growth period) inhibits the growth of Sclerotinia sclerotiorum with an EC50 of 19 μM[1].
(+)-Aureol (150 μM; fungal growth period) inhibits the growth of Botrytis cinerea (62%), Fusarium graminearum (66%), and Phytophthora capsica (57%)[1].
(+)-Aureol (compound 1) exhibits selective cytotoxicity against human nonsmall cell lung cancer A549 cells and human colon adenocarcinoma HT-29 cells[2].
(+)-Aureol possesses potent activity against influenza A virus[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 72853-81-7
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Molecular Weight 314.46
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Formel C21H30O2
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SMILES
C[C@]12[C@@]3(OC4=CC=C(O)C=C4C2)[C@](CC[C@@H]1C)([H])C(C)(CCC3)C
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Structure Classification
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Initial Source
Smenospongia aurea
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Sun S, et al.. Facile Synthesis and First Antifungal Exploration of Tetracyclic Meroterpenoids: (+)-Aureol, (-)-Pelorol, and Its Analogs. Journal of natural products. 2024 Apr 26;87(4):1092-1102. [Content Brief]
[2]. Kuan KK, et al.. Total synthesis of (+)-aureol. Organic letters. 2012 Sep 21;14(18):4710-3. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(+)-Aureol Related Classifications
HY-N20663 Related Classifications
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