- Signaling Pathways
- Metabolic Enzyme/Protease
- Glycosidase
Glycosidase
Glycosidase
- [1]. Wang X, et al. Metabolites extracted from microorganisms as potential inhibitors of glycosidases (α-glucosidase and α-amylase): A review. Front Microbiol. 2022 Nov 17;13:1050869.
- [2]. Ohtsubo K, et al. Glycosylation in cellular mechanisms of health and disease. Cell. 2006 Sep 8;126(5):855-67. [Content Brief]
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Glycosidase Inhibitors
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Glycosidase Substrates
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Glycosidase Ligands
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Glycosidase Related Products (696)
Related Products (696)
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Antibodies (3)
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(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid
0 ImagesCat. No.: HY-N7170CAS No.: 771493-42-6(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid (compound 4) is a α-Glucosidase inhibitor with an IC50 value of 577.7 µM. -
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Ethyl-3,5-di-O-caffeoylquinate
0 ImagesCat. No.: HY-N13813CAS No.: 143051-74-5Ethyl-3,5-di-O-caffeoylquinate is an ethyl caffeoylquinate (ECQ), and ECQ analogs are potential α-glucosidase (α-glucosidase) inhibitors and PTP1B inhibitors. Ethyl-3,5-di-O-caffeoylquinate, which can be isolated from the flower buds of Lonicera macranthoides, is an isomer of chlorogenic acid (ethyl dicaffeoylquinate). -
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Ganomycin I
0 ImagesCat. No.: HY-N10076CAS No.: 1191255-15-8Ganomycin I is a non-competitive dual inhibitor of α-glucosidase and HMG-CoA reductase, with IC50 values of 0.3 μM and 12.3 μM, respectively. Ganomycin I inhibits HIV-1 protease, with an IC50 of 7.5 μg/mL. Ganomycin I also suppresses RANKL-induced osteoclast differentiation and bone resorption by inhibiting the activation of ERK, JNK and p38 MAPK, as well as downregulating the c-Fos/NFATc1 signaling pathway. Ganomycin I exhibits antibacterial activity against Gram-positive bacteria, and shows weak activity against Mycobacterium tuberculosis H37Ra. It can be used in research related to metabolic diseases, bone metabolism and anti-infection. -
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α-Glucosidase-IN-38
0 ImagesCat. No.: HY-155344CAS No.: 2991427-89-3α-Glucosidase-IN-38 (Compound 11j) is a potent inhibitor of α-glucosidase inhibitor with IC50 of 12.44±0.38 μM.α-Glucosidase-IN-38 plays an important role in Diabetes mellitus (DM). -
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α-Glucosidase-IN-24
0 ImagesCat. No.: HY-N11512CAS No.: 60354-05-4α-Glucosidase-IN-24 (Compound 13) is an α-Glucosidase inhibitor with an IC50 of 451 μM. α-Glucosidase-IN-24 can be isolated from Swertia kouitchensis. -
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α-Glucosidase-IN-34
0 ImagesCat. No.: HY-149533α-Glucosidase-IN-34 (compound 7f) is a potent α-glucosidase inhibitor (IC50: 2.90 μM) and can be used in the study of type 2 diabetes and hyperglycemia. -
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Hyaluronidase, Streptomyces hyalurolyticus
0 ImagesCat. No.: HY-108903BHyaluronidase, Streptomyces hyalurolyticus (EC 3.2.1.35) degrades hyaluronan and has been found to be inappropriately regulated during cancer progression. Hyaluronidase randomly cleaves β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates. -
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α-Glucosidase-IN-113
0 ImagesCat. No.: HY-181476CAS No.: 3095548-30-1α-Glucosidase-IN-113 is an α-glucosidase inhibitor with an IC50 of 17.52 μM. α-Glucosidase-IN-113 shows antiglycating activity and inhibits advanced glycation end-product formation. α-Glucosidase-IN-113 can be used for the research of type 2 diabetes. -
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5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl
0 ImagesCat. No.: HY-N11999CAS No.: 838826-34-95,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl (compound 8) can be isolated from Dendrobium infundibulum (D. infundibulum). 5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl has no inhibitory activity against α-glucosidase and pancreatic lipase. -
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α-Glucosidase-IN-27
0 ImagesCat. No.: HY-154998α-Glucosidase-IN-27 (compound 8l) is an α-glucosidase inhibitor (IC50=25.78 μM). α-Glucosidase-IN-27 has the potential to study type 2 diabetes (D2M). -
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N-Formyldehydroanonaine
0 ImagesCat. No.: HY-N17553CAS No.: 165900-12-9N-Formyldehydroanonaine is a potent α-glucosidase inhibitor with an IC50 of 104.6 μM against yeast α-glucosidase. N-Formyldehydroanonaine can be used for the research of diabetes mellitus. -
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- α-Glucosidase-IN-80
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α-Glucosidase-IN-98
0 ImagesCat. No.: HY-178383α-Glucosidase-IN-98 is a potent orally active α-Glucosidase inhibitor with an IC50 of 18.1 μM. α-Glucosidase-IN-98 reversibly binds with α-Glucosidase via hydrogen bonds, electrostatic interactions and hydrophobic effects, which induces significant conformational alterations in the secondary structure of α-Glucosidase. α-Glucosidase-IN-98 decreases postprandial hyperglycemia in Starch (HY-B2225B)/Sucrose (HY-B1779)-challenged mice. α-Glucosidase-IN-98 can be used for type 2 diabetes mellitus (T2DM) research. -
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cis-3-O-Hydroxycinnamoyl-ursolic acid
0 ImagesCat. No.: HY-N19933CAS No.: 331243-42-6cis-3-O-Hydroxycinnamoyl-ursolic acid is a cis-cinnamic acid ester derivative. cis-3-O-Hydroxycinnamoyl-ursolic acid exhibits no α-glucosidase inhibitory activity. -
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α-Amylase/α-Glucosidase-IN-23
0 ImagesCat. No.: HY-179141CAS No.: 2093387-94-9α-Amylase/α-Glucosidase-IN-23 (Compound 5e) is a α-Amylase/α-Glucosidase inhibitor with IC50 values of 73.68 nM for α-glucosidase and 146.18 nM for α-amylase. α-Amylase/α-Glucosidase-IN-23 can be used in the research of hypoglycemia. -
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α-Amylase/α-Glucosidase-IN-12
0 ImagesCat. No.: HY-163439α-Amylase/α-Glucosidase-IN-12 (compound 10k) is a dual inhibitor targeting α-glucosidase and α-amylase with IC50 of 34.52 nM and 24.62 nM, respectively. α-Amylase/α-Glucosidase-IN-12 is an inhibitor designed based on triazolo[4,3-b][1,2,4]triazine and has the potential to be used in diabetes research. -
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LY-23
0 ImagesCat. No.: HY-182289LY-23 is an orally active α-glucosidase inhibitor (Ki = 0.05 μM), with IC50 values of 0.18 μM, 0.14 μM and 0.51 μM against maltase, sucrase and isomaltase, respectively. LY-23 reduces the level of postprandial blood glucose elevation. LY-23 is applicable to research related to postprandial hyperglycemia. -
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α-Amylase/α-Glucosidase-IN-17
0 ImagesCat. No.: HY-172211α-Amylase/α-Glucosidase-IN-17 (Compound 3) is an inhibitor of α-amylase and α-glucosidase, with IC50 values of 14.61 μM and 25.38 μM, respectively. α-Amylase/α-Glucosidase-IN-17 has certain inhibitory activity against A549 cancer cells. α-Amylase/α-Glucosidase-IN-17 has anti-tumor and anti-diabetic effects. -
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α-Glucosidase-IN-32
0 ImagesCat. No.: HY-156078α-Glucosidase-IN-32 (compound f26) is a reversible, noncompetitive and orally active α-glucosidase inhibitor with an IC50 value of 3.07 μM. α-Glucosidase-IN-32 complex with α-glucosidase through hydrogen bonds and hydrophobic interactions, led to changes in the conformation and secondary strictures of α-glucosidase and further the inhibition of the enzymatic activity. α-Glucosidase-IN-32 can be used for diabetic disease research. -
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Glycosidase-IN-2
0 ImagesCat. No.: HY-135670BCAS No.: 476310-39-1Glycosidase-IN-2 (Compound 20) is an azasugar class of glycosidase inhibitor. Glycosidase-IN-2 has hypoglycemic activity. -
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