Insulin Receptor
Insulin receptor (IR), a phylogenetically ancient tyrosine kinase receptor, is a large cell surface glycoprotein that concentrates insulin at the site of action and also initiates responses to insulin. The receptor is a disulfide-linked oligomer comprised of two alpha and two beta subunits. The insulin receptor exists in two isoforms, IR-A and IR-B, expressed in different relative abundance in the various organs and tissues. The two IR isoforms have similar binding affinity for insulin but different affinity for insulin-like growth factor (IGF)-2 and proinsulin, which are bound by IR-A but not IR-B.
The insulin receptor has a crucial role in controlling glucose homeostasis, regulating lipid, protein and carbohydrate metabolism, and modulating brain neurotransmitter levels. Insulin receptor dysfunction has been associated with many diseases, including diabetes, cancer and Alzheimer's disease.
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Insulin Receptor Inhibitors
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Insulin Receptor Agonists
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Insulin Receptor Antagonists
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Insulin Receptor Activators
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Insulin Receptor Modulators
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Insulin Receptor Inducer
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Insulin Receptor Degrader
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Insulin Receptor Substrates
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Insulin Receptor Ligand
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Insulin Receptor (INSR) Proteins
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INSR/CD220 Proteins
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Insulin Receptor Verwandte Produkte (204)
Verwandte Produkte (204)
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Recombinant Proteins (8)
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Antibodies (8)
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D-Galactose pentaacetate
0 ImagesArt. -Nr.: HY-W102387CAS. Nr.: 25878-60-8Synonyms: Pentaacetyl-D-galactopyranoseD-Galactose pentaacetate inhibits leucine-induced insulin release. D-Galactose pentaacetate can be used for the research of persistent hyperinsulinemia in childhood or insulinoma.
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Rhoifolin (Standard)
0 ImagesRhoifolin (Standard) is the analytical standard of Rhoifolin. This product is intended for research and analytical applications. Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines.
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NBI-6024
0 ImagesArt. -Nr.: HY-106171CAS. Nr.: 239480-61-6NBI-6024, an altered peptide ligand (APL), is an epitope recognized by inflammatory interferon-gamma-producing T helper lymphocytes in type 1 diabetic patients.
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GIP, rat
0 ImagesArt. -Nr.: HY-P5390Reinheit: 98.44%GIP, rat is a bioactive peptide derived from rats. GIP, rat inhibits GIP-mediated postprandial insulin release as well as GIP-promoted glucose uptake in the upper small intestine. GIP, rat can be used in research related to insulin resistance, glucose intolerance, and type 2 diabetes.
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HNMPA
0 ImagesHNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities
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Pancreastatin (37-52), human
0 ImagesArt. -Nr.: HY-P3864CAS. Nr.: 133605-57-9Pancreastatin (37-52), human is a pancreastatin fragment. Pancreastatin a CgA-derived peptide (CgA residues 250–301) with biological activity, inhibited the releasing of insulin by islet beta cells.
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Bilpatide
0 ImagesArt. -Nr.: HY-P12137CAS. Nr.: 2869056-74-4Synonyms: RAY1225Bilpatide (RAY1225) is a dual agonist of glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR). Bilpatide is applicable to research related to obesity and diabetes.
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SaRI 59-801
0 ImagesArt. -Nr.: HY-121565CAS. Nr.: 80565-58-8
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IMP2-IN-3
0 ImagesArt. -Nr.: HY-150255CAS. Nr.: 1448353-63-6IMP2-IN-3 is a potent IMP2 inhibitor. IMP2-IN-3 shows anticancer effects.
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Ceritinib mesylate
0 ImagesArt. -Nr.: HY-15656BCAS. Nr.: 2055376-74-2Synonyms: LDK378 mesylate
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Glyceollin III
0 ImagesArt. -Nr.: HY-N18033CAS. Nr.: 61080-23-7Glyceollin III is a glyceollin found in soybeans. Glyceollin III enhances insulin-stimulated glucose uptake and increases glucagon-like peptide-1 (GLP-1) secretion. Glyceollin III can be used for the research of type 2 diabetes.
![[Pro3]-GIP (Rat)](https://file.medchemexpress.com/product_pic/hy-p1433.gif "Click to View [Pro3]-GIP (Rat) Product Detail")
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Tirzepatide sodium
0 ImagesArt. -Nr.: HY-P1731CSynonyms: LY3298176 sodiumTirzepatide sodium (LY3298176 sodium) is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Tirzepatide sodium exerts anti-apoptotic and pro-differentiation effects via the pAkt/CREB/BDNF cascade and miRNA in neurons; in the heart, it promotes BCAA catabolism and inhibits the mTOR pathway by mediating the dephosphorylation of BCKDHA; meanwhile, it effectively reduces insulin and leptin levels and suppresses inflammatory responses at the systemic level. Tirzepatide sodium can be used for research on myocardial infarction, colon cancer, diabetes, diabetic cognitive impairment, neurodegeneration, diabetes-related neuropathy, and obesity.
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BMS-986118
0 ImagesArt. -Nr.: HY-12413ACAS. Nr.: 1610562-74-7BMS-986118 is an orally active and selective GPR40 full agonist (EC50 = 0.07 μM). BMS-986118 induces GLP-1 secretion and increases GLP-1 and insulin levels when combined with DPP-4 inhibitors. BMS-986118 shows sustained glucose-lowering effects. BMS-986118 can be used for research on type 2 diabetes.
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[Tyr0] Gastric Inhibitory Peptide (23-42), human
![[Tyr0] Gastric Inhibitory Peptide (23-42), human](https://file.medchemexpress.com/product_pic/hy-p3577.gif "Click to View [Tyr0] Gastric Inhibitory Peptide (23-42), human Product Detail")
0 ImagesArt. -Nr.: HY-P3577CAS. Nr.: 121765-67-1[Tyr0] Gastric Inhibitory Peptide (23-42), human, a glucose-dependent insulinotropic polypeptide (GIP), is a weak inhibitor of gastric acid secretion that also stimulates insulin secretion. [Tyr0] Gastric Inhibitory Peptide (23-42), human can be used in diabetes, obesity research.
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IRS-1 Peptide, FAM labeled
0 ImagesArt. -Nr.: HY-P5433FCAS. Nr.: 1600503-54-5IRS-1 Peptide, FAM labeled is a biological active peptide. (Insulin receptor substrate)
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GTx-134
0 ImagesArt. -Nr.: HY-13312ACAS. Nr.: 1008448-19-8GTx-134 is a dual insulin-like growth factor 1 receptor/insulin receptor (IGF-1R/IR) inhibitor with an IC50 values for IGF-1R and IR of 97 and 187 nM respectively. GTx-134 inhibits the autophosphorylation of IGF-1R and its downstream signaling pathway (Akt), thereby blocking the proliferation and survival signals of tumor cells. GTx-134 has broad-spectrum inhibitory activity against multiple myeloma cell lines and can induce apoptosis in sensitive cells. GTx-134 significantly inhibits tumor growth in mice with MM1.S cell transplantation. GTx-134 works in synergy with existing therapies (such as protease preparations, immunomodulators). GTx-134 can be used in high-risk myeloma research.
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CPF-7
0 ImagesArt. -Nr.: HY-P5291CAS. Nr.: 103238-06-8Synonyms: Caerulein precursor fragmentCPF-7 (Caerulein precursor fragment) is an insulin-releasing peptide that stimulates the release of insulin. CPF-7 can induce epithelial-mesenchymal transition by upregulating Snai1 expression in PANC-1 ductal cells. CPF-7 also induces exocrine plasticity by upregulating Ngn3 expression. CPF-7 can be used in the research of type 2 diabetes.
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BM-131246
0 ImagesArt. -Nr.: HY-101758CAS. Nr.: 103787-97-9BM-131246 is an oral antidiabetic agent.
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Semaglutide, Cy5 labeled
0 ImagesArt. -Nr.: HY-114118F5Synonyms: Semaglutide-Cys(Cy5)Semaglutide, Cy5-labeled (Semaglutide-Cys(Cy5)) is a CY5 (HY-D0821) -labeled version of Semaglutide (HY-114118) (Ex/Em = 633/670 nm). Semaglutide, Cy5-labeled can be used for studies on Semaglutide receptor binding (GLP-1R), cellular uptake and endocytosis, in vivo tissue distribution, and the targeting efficiency of delivery systems.
