αIIbβ3 Activator
-
A2P5P
0 ImagesA2P5P (2',5'-ADP) is a P2Y1 purinergic receptor antagonist and ribonuclease inhibitor. A2P5P selectively blocks Adenosine 5'-diphosphate (ADP) (HY-W010918)-induced P2Y1-mediated phospholipase C activation and intracellular Ca2+ mobilization, is selective for P2Y2/P2Y4 with no significant effect on P2Y11, thereby inhibiting platelet shape change, aggregation, actin (Actin) polymerization, early αIIbβ3 activation, granule centralization, filopodia formation, and serotonin secretion, without affecting Thrombin (MW 37kDa) (HY-114164)-induced aggregation. A2P5P also binds to the catalytic site of RNase A (HY-129046), EDN, and ECP, inhibiting ribonucleolytic activity through water-mediated hydrogen bonds and transglycosidic/ribose conformations, stabilizing the inactive catalytic histidine conformation. A2P5P can be used for research on platelet function and ribonuclease-related studies.
