MMP
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matrix components and regulate extracellular protein turnover[1]. Mechanistically, MMPs also cleave cell-surface molecules and pericellular non-matrix proteins, thereby regulating cell behavior beyond matrix degradation[1]. In disease models, abnormal MMP and TIMP regulation contributes to inflammation, tissue destruction, fibrosis, abnormal wound repair, vascular disease, and cancer progression[2]. Compared with related isoforms, MMP-2 and MMP-9 are gelatinases, while MMP-14 is a membrane-associated MT1-MMP that supports localized pericellular matrix remodeling[3]. For experimental applications, active-MMP profiling can use batimastat affinity resin to capture active MMPs and related ADAMs for mass-spectrometry identification[3].
References:
- [1]. Sternlicht MD, et al. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001;17:463-516. [Content Brief]
- [2]. Cabral-Pacheco GA, et al. The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases. Int J Mol Sci. 2020 Dec 20;21(24):9739. [Content Brief]
- [3]. Chang M. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. doi: 10.1039/d2ra07005g. PMID: 36825288; PMCID: PMC9942564. et al. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. [Content Brief]
All Product Categories
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MMP Related Products (446)
Related Products (446)
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Edaravone sulfate-d5
0 ImagesCat. No.: HY-W801479SEdaravone sulfate-d5 is the deuterium labeled Edaravone sulfate. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.
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Mmp13 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS08527Mmp13 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp13 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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3-Ethyltoluene
0 ImagesSynonyms: 3-Methylethylbenzene3-Ethyltoluene (3-Methylethylbenzene) is an isomer of Ethyltoluenes. 3-Ethyltoluene inhibits cell survival and proliferation and increases ROS production. 3-Ethyltoluene upregulates cellular inflammatory gene expression. 3-Ethyltoluene induces cell fibrosis with increased level of AST, FGF-23, Cyt-7 p21, TGFβ, TIMP2, and MMP2. 3-Ethyltoluene can be used for liver diseases such as NAFLD research.
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Mmp10 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS08519Mmp10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Highly purified Type IX collagen, from bovine articular cartilage
0 ImagesCat. No.: HY-NP105Synonyms: Bovine Type IX collagen, immunization gradeHighly purified Type IX collagen, from bovine articular cartilage (Bovine Type IX collagen, immunization grade) is an immune grade collagen derived from bovine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
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MMP Inhibitor 4
0 ImagesCat. No.: HY-168560MMP Inhibitor 4 (compound 4 B) is a potent MMP inhibitor. MMP Inhibitor 4 shows antiproliferative activity. MMP Inhibitor 4 induces cell cycle arrest at subG1 phase. MMP Inhibitor 4 decreases the mRNA expression of MMP2, MMP9 and VEGFA.
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Anticancer agent 204
0 ImagesCat. No.: HY-162453CAS No.: 3034640-70-2Anticancer agent 204 (Compound 6), a cinnamide fluorinated derivative, possesses anticancer activity. Anticancer agent 204 can arrest the cell cycle of HepG2 cells in the G1 phase and induce apoptosis by reducing the level of mitochondrial membrane polarization (MMP).
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TNO211 TFA
0 ImagesCat. No.: HY-P5380ASynonyms: Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2 TFATNO211 (Dabcyl-GABA-Pro-Gln-Gly-Leu-Glu(EDANS)-Ala-Lys-NH2) TFA is a fluorogenic substrate, containing the MMP cleavable Gly-Leu bond and EDANS/Dabcyl as fluorophore/quencer combination. TNO211 TFA can specifically detect MMP activity (Ex/Em = 340/485 nm).
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Ro 32-7315
0 ImagesCat. No.: HY-123736CAS No.: 219613-02-2Ro 32-7315 is a TNF-α converting enzyme (TACE) inhibitor.
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Mca-AQTLTL-Dpa-RSSSQ-NH2
0 ImagesCat. No.: HY-P12222Mca-AQTLTL-Dpa-RSSSQ-NH2 is a fluorescent substrate peptide for TNF-α converting enzyme (TACE), with its peptide sequence spanning the TACE cleavage site of tmTNF. In its intact state, the fluorescence of Mca-AQTLTL-Dpa-RSSSQ-NH2 is quenched; upon cleavage by TACE, a fluorescent signal is released, thereby reflecting TACE enzymatic activity. Mca-AQTLTL-Dpa-RSSSQ-NH2 can be used for studies related to TACE activity and TACE inhibition.
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Anti-TIMP-1 Antibody
0 ImagesCat. No.: HY-P992307
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GPVGPS
0 ImagesCat. No.: HY-P11890CAS No.: 1154403-54-9GPVGPS is a low-molecular-weight fish collagen peptide. GPVGPS upregulates the expression of vascular endothelial growth factor (VEGF), PCNA, hepatocyte growth factor, epidermal growth factor (EGF) , and insulin-like growth factor 1 (IGF-1), and downregulates the expression of negative regulatory proteins associated with hair health. GPVGPS inhibits MMP-1, MMP-2, and MMP-9, increases skin water content, reduces wrinkles, and improves oxidative stress status and pro-inflammatory cytokine levels. GPVGPS can be used in studies related to hair loss and UVB-induced skin photoaging.
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RLVT-14-02
0 ImagesCat. No.: HY-P991478RLVT-14-02 is a human monoclonal antibody (mAb) targeting MMP14. RLVT-14-02 can be used in neuropathic pain research.
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Tubulin/MMP-IN-3
0 ImagesCat. No.: HY-172088Tubulin/MMP-IN-3 (Compound 15j) is the dual inhibitor for tubulin polymerization and MMP, and inhibits MMP-2 and MMP-9 with IC50 of 21.13 μM and 19.24 μM. Tubulin/MMP-IN-3 inhibits NF-κB signaling pathway, causes mitochondrial dysfunction and the apoptosis through a mitochondrial-dependent pathway. Tubulin/MMP-IN-3 exhibits antiproliferative activity in a variety of cancer cells, arrests the cell cycle at G2/M phase, and exhibits antitumor efficacy in mouse models.
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Highly purified Type II collagen, from goat articular cartilage
0 ImagesCat. No.: HY-NP130Synonyms: Goat Type II collagen, immunization gradeHighly purified Type II collagen, from goat articular cartilage (Goat Type II collagen, immunization grade) is an immune grade collagen derived from goat articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
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Dnp-PLGLWAr-NH2 acetate
0 ImagesCat. No.: HY-P10139APurity: 98.86%Dnp-PLGLWAr-NH2 acetate is a synthetic collagenase/gelatinase substrate. Dnp-PLGLWAr-NH2 acetate can be used to quantify total MMP activity in APMA-activated conditioned medium samples.
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T-5224-d8
0 ImagesCat. No.: HY-12270ST-5224-d8 is the deuterium labeled T-5224 (HY-12270). T-5224 is a transcription factor c-Fos/activator protein (AP)-1 inhibitor with anti-inflammatory effects, which specifically inhibits the DNA binding activity of c-Fos/c-Jun without affecting other transcription factors. T-5224 inhibits the IL-1β-induced up-regulation of Mmp-3, Mmp-13 and Adamts-5 transcription.
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U27391
0 ImagesCat. No.: HY-114581CAS No.: 106314-87-8U27391 is a metalloproteinase inhibitor. U27391 inhibits rhIL-1β Induced proteoglycan loss.
