MMP
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matrix components and regulate extracellular protein turnover[1]. Mechanistically, MMPs also cleave cell-surface molecules and pericellular non-matrix proteins, thereby regulating cell behavior beyond matrix degradation[1]. In disease models, abnormal MMP and TIMP regulation contributes to inflammation, tissue destruction, fibrosis, abnormal wound repair, vascular disease, and cancer progression[2]. Compared with related isoforms, MMP-2 and MMP-9 are gelatinases, while MMP-14 is a membrane-associated MT1-MMP that supports localized pericellular matrix remodeling[3]. For experimental applications, active-MMP profiling can use batimastat affinity resin to capture active MMPs and related ADAMs for mass-spectrometry identification[3].
References:
- [1]. Sternlicht MD, et al. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001;17:463-516. [Content Brief]
- [2]. Cabral-Pacheco GA, et al. The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases. Int J Mol Sci. 2020 Dec 20;21(24):9739. [Content Brief]
- [3]. Chang M. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. doi: 10.1039/d2ra07005g. PMID: 36825288; PMCID: PMC9942564. et al. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. [Content Brief]
All Product Categories
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MMP Related Products (446)
Related Products (446)
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MMP7 Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS08551MMP7 Human Pre-designed siRNA Set A contains three designed siRNAs for MMP7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Anti-ADAM17 Antibody
0 ImagesCat. No.: HY-P992185
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BT1769
0 ImagesCat. No.: HY-P10775BT1769 is a MT1-MMP-targeted (KD = 3.35 nM) Bicycle toxin conjugate. BT1769 can be used in the study for osteosarcoma. BT1769 consists of a novel bicyclic targeting peptide that selectively binds MT1-MMP; a cytotoxin MMAE; and an enzymatically cleavable dipeptide linker.
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PTIQ
0 ImagesCat. No.: HY-107617CAS No.: 1032822-42-6PTIQ can suppress MMP-3 production, can enter the brain and provide neuroprotection. PTIQ has anti-inflammatory effects on microglial cells.
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SH491
0 ImagesCat. No.: HY-155960CAS No.: 2975285-28-8SH491 (Compound 33) is an antiosteoporosis agent. SH491 inhibits RANKL-induced osteoclast differentiation on bone-marrow-derived monocytes (BMMs) (IC50: 11.8 nM). SH491 inhibits the expression of osteoclastogenesis-related marker genes (TRAP, CTSK, MMP-9, and ATPase v0d2) and proteins (TRAP, CTSK, MMP-9).
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MMP13-IN-5
0 ImagesCat. No.: HY-149378MMP13-IN-5 (compound 13m) is a potent and selective inhibitor of MMP-2/MMP-13 (IC50=3.6 μM/14.6 μM)，involved in osteoarthritis (OA).
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Actinonin (Standard)
0 ImagesCat. No.: HY-113952RCAS No.: 13434-13-4Synonyms: (-)-Actinonin (Standard)Actinonin (Standard) is the analytical standard of Actinonin. This product is intended for research and analytical applications. Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].
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Isoliquiritin apioside (Standard)
0 ImagesCat. No.: HY-N2497RCAS No.: 120926-46-7Isoliquiritin apioside (Standard) is the analytical standard of Isoliquiritin apioside. This product is intended for research and analytical applications. Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.
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Mmp12 Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS08523Mmp12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mmp12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
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YYRADDA
0 ImagesCat. No.: HY-P5263CAS No.: 1082226-36-5YYRADDA is a polypeptide. YYRADDA stimulates the growth of collagen in the extracellular matrix of the skin. YYRADDA improves the appearance of the skin and promotes the healing of damaged skin.
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BAY-7598
0 ImagesCat. No.: HY-120944CAS No.: 1816257-74-5BAY-7598, a chemical probe, is a potent, orally bioavailable, and selective MMP12 inhibitor with IC50s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.
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Anti-ADMAST4 Antibody
0 ImagesCat. No.: HY-P992186
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Highly purified Type IX collagen, from chick articular cartilage
0 ImagesCat. No.: HY-NP114Synonyms: Chick Type IX collagen, immunization gradeHighly purified Type IX collagen, from chick articular cartilage (Chick Type IX collagen, immunization grade) is an immune grade collagen derived from chick articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
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Rilpivirine hydrochloride (Standard)
0 ImagesSynonyms: TMC-278 hydrochloride (Standard); TMC278 hydrochloride (Standard); TMC 278 hydrochloride (Standard)Rilpivirine (hydrochloride) (Standard) is the analytical standard of Rilpivirine (hydrochloride). This product is intended for research and analytical applications. Rilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV.
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Highly purified Type V collagen, from mouse intestine
0 ImagesCat. No.: HY-NP111Synonyms: Mouse Type V collagen, immunization gradeHighly purified Type V collagen, from mouse intestine (Mouse Type II collagen, immunization grade) is an immune grade collagen derived from mouse intestine, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
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ZM-32
0 ImagesCat. No.: HY-163760CAS No.: 2667585-44-4ZM-32 is an inhibitor for human antigen R (HuR), that downregulates the expression of VEGF-A and MMP9, and thus inhibits breast cancer tumor angiogenesis. ZM-32 exhibits broad-spectrum anti-proliferative effects in a variety of cancer cell lines, and exhibits antitumor efficacy against MDA-MB-231 in mouse models.
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Mmp12 Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS08524Mmp12 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mmp12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Antitumor agent-132
0 ImagesCat. No.: HY-162131Antitumor agent-132 (Compound F9) is an antitumor agent. Antitumor agent-132 induces cell apoptosis and increases intracellular reactive oxygen species and reduces MMP.
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2-Methoxy-2,4-diphenylfuran-3-one
0 ImagesCat. No.: HY-W277900CAS No.: 50632-57-0
