MMP
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that degrade extracellular matrix components and regulate extracellular protein turnover[1]. Mechanistically, MMPs also cleave cell-surface molecules and pericellular non-matrix proteins, thereby regulating cell behavior beyond matrix degradation[1]. In disease models, abnormal MMP and TIMP regulation contributes to inflammation, tissue destruction, fibrosis, abnormal wound repair, vascular disease, and cancer progression[2]. Compared with related isoforms, MMP-2 and MMP-9 are gelatinases, while MMP-14 is a membrane-associated MT1-MMP that supports localized pericellular matrix remodeling[3]. For experimental applications, active-MMP profiling can use batimastat affinity resin to capture active MMPs and related ADAMs for mass-spectrometry identification[3].
References:
- [1]. Sternlicht MD, et al. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 2001;17:463-516. [Content Brief]
- [2]. Cabral-Pacheco GA, et al. The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases. Int J Mol Sci. 2020 Dec 20;21(24):9739. [Content Brief]
- [3]. Chang M. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. doi: 10.1039/d2ra07005g. PMID: 36825288; PMCID: PMC9942564. et al. Matrix metalloproteinase profiling and their roles in disease. RSC Adv. 2023 Feb 21;13(9):6304-6316. [Content Brief]
All Product Categories
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MMP Related Products (441)
Related Products (441)
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PDZ1i
0 ImagesSynonyms: 113B7PDZ1i (113B7) is a inhibitor of MDA-9/Syntenin, with selective binding to the PDZ1 domain. PDZ1i inhibits radiation-induced invasion of glioblastoma (GBM) cells, radiosensitizes GBM cells, and impairs GBM-related signaling pathways (including Src/EphA2, EGFRvIII/FAK, and NF-κB). PDZ1i reduces radiation-induced secretion of invasion-related proteases (MMP-2, MMP-9, ADAM9). PDZ1i shows anti-tumor effects in nude mice bearing intracranial U1242-luc xenografts or GBM xenografts. PDZ1i can be used for the study of glioblastoma (GBM), breast cancer and prostate cancer.
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H-Gly-Pro-Hyp-OH
0 ImagesH-Gly-Pro-Hyp-OH is a collagen-derived peptide and also a dipeptidyl peptidase-4 inhibitor.\nH-Gly-Pro-Hyp-OH inhibits the activity of dipeptidyl peptidase-4 in vitro. H-Gly-Pro-Hyp-OH binds to the DNA-binding site of the JUN/FOS complex, blocks the formation of the DNA-JUN/FOS complex, and inhibits transcriptional activity. H-Gly-Pro-Hyp-OH is applicable to research related to skin photoaging, UVB-induced skin aging/photoaging, and thrombosis.
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Highly purified Type II collagen, from chick sternal cartilage
0 ImagesCat. No.: HY-NP113Purity: 99.00%Synonyms: Chick Type II collagen, immunization gradeHighly purified Type II collagen, from chick sternal cartilage (Chick Type II collagen, immunization grade) is an immune grade collagen derived from chick sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
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Triolein-d5
0 ImagesCat. No.: HY-N1981S1CAS No.: 60892-83-3Triolein-d5 is the deuterium labeled Triolein. Triolein is a symmetrical triacylglycerol, reduces MMP-1 upregulation, with strong antioxidant and anti-inflammatory properties.
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Methacrylated Type I collagen
0 ImagesCat. No.: HY-158225Synonyms: Col1MAMethacrylated Type I collagen (Col1MA) is a methacrylated tissue engineering scaffold material that retains the basic properties of natural collagen. Methacrylated Type I collagen needs to self-assemble into fibrous hydrogel under the action of photoinitiator LAP (HY-44076), and target bioactive adhesion sites, play an inherent supporting role for tissue cells and biodegradable activity.
Application: cell culture, biological 3D printing, tissue engineering, etc.
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Doxycycline hyclate (Standard)
0 ImagesCat. No.: HY-N0565BRCAS No.: 24390-14-5Synonyms: Doxycycline hydrochloride hemiethanolate hemihydrate (Standard); WC2031 (Standard)Doxycycline hyclate (Standard) is the analytical standard of Doxycycline hyclate (HY-N0565B). This product is intended for research and analytical applications. Doxycycline hyclate is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline hyclate is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline hyclate also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline hyclate induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline hyclate also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline hyclate has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers.
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Cyanidin 3-sambubioside chloride
0 ImagesSynonyms: Cyanidin-3-O-sambubioside chlorideCyanidin 3-sambubioside chloride (Cyanidin-3-O-sambubioside chloride), a major anthocyanin, a natural colorant, and is a potent NO inhibitor. Cyanidin 3-sambubioside chloride is a H274Y mutation inhibitor, and inhibits influenza neuraminidase activity with an IC50 of 72 μM. Cyanidin 3-sambubioside chloride inhibits angiotensin-converting enzyme (ACE) activity and has antioxidant, anti-angiogenic and antiviral properties.
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(-)-Epigallocatechin (Standard)
0 ImagesSynonyms: Epigallocatechin(Standard); L-Epigallocatechin (Standard)(-)-Epigallocatechin (Standard) is the analytical standard of (-)-Epigallocatechin. This product is intended for research and analytical applications. (-)-Epigallocatechin (Epigallocatechin) is the most abundant flavonoid in green tea, can bind to unfolded native polypeptides and prevent conversion to amyloid fibrils.
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GPLGIAGQ
0 ImagesGPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).
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Tranexamic acid (Standard)
0 ImagesTranexamic acid (Standard) is the analytical standard of Tranexamic acid. This product is intended for research and analytical applications. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .
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Hexapeptide-11
0 ImagesHexapeptide-11 is an anti-aging peptide that can protect fibroblasts from premature cell senescence mediated by oxidative stress. Hexapeptide-11 is also a potential stimulator of hyaluronic acid in keratinocytes, and can enhance skin barrier function by upregulating the expression of HAS2 and EGR3, and downregulating the expression of HYAL2. Hexapeptide-11 can also improve skin elasticity.
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DL-erythro-Dihydrosphingosine
0 ImagesDL-erythro-Dihydrosphingosine is a sphingosine-based PKC inhibitor. DL-erythro-Dihydrosphingosine directly inhibits the enzymatic activity of PLA2. DL-erythro-Dihydrosphingosine inhibits the activity of Bcl-2 protein involved in apoptosis. DL-erythro-Dihydrosphingosine inhibits the activity of matrix metalloproteinases (MMP). DL-erythro-Dihydrosphingosine is applicable for research on cancer and inflammatory diseases.
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PTPσ Inhibitor, ISP
0 ImagesCat. No.: HY-P5982PTPσ Inhibitor, ISP is a PTPσ intracellular wedge domain mimetic peptide containing a TAT cell-penetrating domain, which acts as a PTPσ inhibitor. PTPσ Inhibitor, ISP binds to and inhibits PTPσ, thereby relieving CSPG-mediated axonal growth inhibition. PTPσ Inhibitor, ISP enhances CSPG degradation by promoting the secretion of Cathepsin B or MMP-2, and promotes DRG axonal growth, OPC migration and remyelination. PTPσ Inhibitor, ISP promotes nerve regeneration and improves sensory, motor and urinary functions in animal models of spinal cord injury, dorsal root injury and multiple sclerosis. PTPσ Inhibitor, ISP also increases the phosphorylation of ERK and AKT in colorectal cancer cells. PTPσ Inhibitor, ISP can be used in studies related to PTPσ/CSPG signaling, nerve regeneration, demyelinating diseases and RAS/ERK signaling.
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Rilpivirine hydrochloride
0 ImagesSynonyms: TMC-278 hydrochlorideRilpivirine (R278474) hydrochloride is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine hydrochloride has high antiviral activity against wild-type HIV (EC50=0.4 nM) and mutant viruses (EC50=0.1-2.0 nM). Rilpivirine hydrochloride has a high genetic barrier to resistance development of HIV.
