Monoamine Oxidase Inhibitor

BW1370U87 is an inhibitor of monoamine oxidase-A with anti-depression activity.

3-Amino-2-oxazolidinone (Standard) (AOZ (Standard)) is the analytical standard of 3-Amino-2-oxazolidinone (HY-W012982). This product is intended for research and analytical applications. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo. 3-Amino-2-oxazolidinone is orally active.

Harmane-d₄ is deuterium-labeled Harmane (HY-101392).

6-Acetonyl-N-methyldihydrodecarine is a natural alkaloid that can be isolated from roots of Zanthoxylum rigidum. An inhibitor of monoamine oxidases.

Tedizolid phosphate (TR-701FA) sodium is a MAO-A and MAO-B inhibitor with activity against Gram-positive bacteria.

Rasagiline (mesylate) (Standard) is the analytical standard of Rasagiline (mesylate). This product is intended for research and analytical applications. Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43?nM and 412?nM for rat brain MAO B and A activity, respectively. Rasagiline (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

MD 220661 is a semicarbazide-sensitive amine oxidase (SSAO) and monoamine oxidase (MAO) inhibitor, and serves as a major metabolite of MD 240928 in rat brain. MD 220661 acts as a substrate for SSAO and exhibits reversible, selective MAO-B inhibition in rat tissues; in the absence of semicarbazide, its inhibitory potency against MAO-A activity decreases with prolonged pre-incubation time. MD 220661 is applicable to studies related to enzyme-catalyzed metabolism.

Moclobemide (Standard) is the analytical standard of Moclobemide. This product is intended for research and analytical applications. Moclobemide (Ro111163) is a brain-penetrant and reversible monoamine oxidase (MAO-A) inhibitor with an IC₅₀ of 6.061 μM for hMAO-A.Moclobemide up-regulates proliferation of hippocampal progenitor cells in chronically stressed mice.

NW-1172 (free base) (compound 22b) is a 5-HT3 receptor antagonist with performance-enhancing activity in a delayed matching task in monkeys, with the (R) isomer producing more systematic improvements than the (S) isomer, a difference paralleled by the higher affinity of the (R) enantiomer for the 5-HT3 receptor.

SZV-558 is a potent and selective MAO-B inhibitor with IC₅₀ values of 50 and 60 nM for rats and humans, respectively. SZV-558 can be used in studies of Parkinson's disease (PD) models.

MAO-A/B-IN-4 is an orally active MAO-A/B inhibitor, with IC₅₀ values of 51.3 μM and 47.0 μM, respectively. MAO-A/B-IN-4 exhibits potent activity against S. aureus, MSSA, MRSA, LRSA, and LREFa. MAO-A/B-IN-4 demonstrates potent antibacterial efficacy in a mouse model of LRSA peritonitis infection. MAO-A/B-IN-4 can be used for the study of bacterial infections.

DL-Thyroxine, a thyroid hormone, is a monoamine oxidase inhibitor.

(±)-Selegiline (Deprenyl) is the racemic of Selegiline (HY-14198). Selegiline is a potent, selective and irreversible inhibitor of MAO-B, with an IC₅₀ of 51 nM. Selegiline exhibits 450-flod selectivity for MAO-B over MAO-A (IC₅₀=23 μM). Selegiline can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder.

Minaprine dihydrochloride (Standard) is the analytical standard of Minaprine dihydrochloride (HY-B0884A). This product is intended for research and analytical applications. Minaprine dihydrochloride is a brain-penetrant monoamine oxidase inhibitor. Minaprine dihydrochloride also weakly inhibits acetylcholinesterase (AChE) activity. Minaprine dihydrochloride reduces intraneuronal dopamine metabolism, lowers striatal homovanillic acid and dihydroxyphenylacetic acid levels, and raises striatal 3-methoxytyramine and 5-hydroxytryptamine levels. Minaprine dihydrochloride exhibits convulsant, antidepressant properties.

NW-1772 (methanesulfonate) (compound 22b) is a potent and selective monoamine oxidase (MAO) B inhibitor. NW-1772 has some advantages, such as rapid blood-brain barrier penetration, short-acting and reversible inhibitory activity, slight inhibition of selected cytochrome P450s, and low in vitro toxicity. NW-1772 can be used for the research of neurodegenerative diseases.

Lilly 51641 (LY-51641) is a selective and orally active Type A monoamine oxidase inhibitor. Lilly 51641 has the potential for the research of depressed and schizophrenic.

hMAO-A-IN-1 (compound 8) is a potent hMAO-A inhibitor, with an IC₅₀ of 90 nM. hMAO-A-IN-1 can be used for the research of anxiety and depression.

5-(2-Aminopropyl)indole is an orally active psychoactive substance, that shows inhibitory activity against monoamine oxidase (MAO) and long-lasting stimulatory properties.

Safinamide (Standard) is the analytical standard of Safinamide. This product is intended for research and analytical applications. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC₅₀=0.098 µM) over MAO-A (IC₅₀=580 µM). Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC₅₀=8 µM) than at resting (IC₅₀=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al.

Brofaromine (hydrochloride) is a monoamine oxidase A (MAO-A) inhibitor and a 5-HT uptake inhibitor. Brofaromine (hydrochloride) shows antidepressant-like activity in the social conflict test in rats.