Neuropeptide Y Receptor
NPY receptor
Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.
Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).
Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.
Neuropeptide Y Receptor Isoform Specific Products
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Neuropeptide Y Receptor Inhibitors
(15)
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Neuropeptide Y Receptor Agonists
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Neuropeptide Y Receptor Antagonists
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Neuropeptide Y Receptor Activators
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Neuropeptide Y Receptor Modulators
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Neuropeptide Y Receptor Control
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Neuropeptide Y Receptor Related Products (181)
Related Products (181)
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Antibodies (8)
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Neuropeptide Y Receptor Isoform Comparison
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Levitide
0 ImagesCat. No.: HY-P2019CAS No.: 114281-19-5Levitide is a neurohormone-like peptide, can be isolated from skin secretions of the South African frog Xenopus laevis. Levitide comes from preprolevitide, is 88 residues long and contains contains the levitide peptide at the C terminus (Glu-Gly-Met-Ile-Gly-Thr-Leu-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2) and the putative signal sequence at the N terminus.
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[D-His26]-Neuropeptide Y, human, rat
![[D-His26]-Neuropeptide Y, human, rat](https://file.medchemexpress.com/product_pic/hy-p10545.gif "Click to View [D-His26]-Neuropeptide Y, human, rat Product Detail")
0 ImagesCat. No.: HY-P10545[D-His26]-Neuropeptide Y, human, rat is a synthetic variant of neuropeptide Y (NPY). [D-His26]-Neuropeptide Y, human, rat acts as a Y1R agonist that can prevent the development of anxiety, social impairment, and depressive symptoms, and has the potential to be used as an early intervention treatment for post-traumatic stress reactions.
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Pancreatic Polypeptide, rat
0 ImagesCat. No.: HY-P1532CAS No.: 90419-12-8Synonyms: Rat pancreatic polypeptidePancreatic Polypeptide, rat (Rat pancreatic polypeptide) is a rat-derived Pancreatic Polypeptide. Pancreatic Polypeptide is a preferential agonist of NPYR4. Pancreatic Polypeptide, rat protects cells against Streptozotocin (HY-13753)-induced DNA damage. Pancreatic Polypeptide, rat inhibits glucose-stimulated insulin secretion. Pancreatic Polypeptide, rat (TFA) can be used in diabetes-related research.
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(R)-JNJ-31020028
0 ImagesCat. No.: HY-107479CAS No.: 1094873-17-2(R)-JNJ-31020028 is a high affinity, selective brain penetrant neuropeptide Y Y2 receptor antagonist, with pIC50 values of 8.07, 8.22 and 8.21 for human, rat, and mouse Y2 receptor, respectively. (R)-JNJ-31020028 shows >100-fold selective versus human Y1, Y4, and Y5 receptors. (R)-JNJ-31020028 has antidepressant like effects.
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Ala5-Galanin (2-11)
0 ImagesCat. No.: HY-P5896CAS No.: 859843-84-8Ala5-Galanin (2-11) is a galanin receptor 2 (GAL2R) specific agonist with a Ki of 258 nM.
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Neuropeptide Y (2-36) (porcine)
0 ImagesCat. No.: HY-P3677CAS No.: 102961-52-4Neuropeptide Y (2-36) (porcine) is a porcine-derived neuropeptide with 97.14% homology to rat/human origin. Neuropeptide Y (2-36) (porcine) is also a rat neuropeptide receptor agonist, with EC50 values of 1.2, 1.6 and 3.4 nM for receptor of Y5, Y2 and Y1 respectively. Neuropeptide Y (2-36) (porcine) can be used in studies related to obesity and eating disorders.
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Neuropeptide SF(mouse,rat) TFA
0 ImagesCat. No.: HY-P1249ANeuropeptide SF (mouse,rat) TFA is a potent neuropeptide FF receptor agonist with Ki values are 48.4 nM and 12.1 nM for NPFF1 and NPFF2, respectively. Neuropeptide SF TFA increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) .
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Galanin-Like Peptide (porcine)
0 ImagesCat. No.: HY-P5064CAS No.: 245114-96-9Galanin-Like Peptide (porcine) is a 60 amino acid neuropeptide that was first isolated from the porcine hypothalamus. Galanin-Like Peptide (porcine) has a high affinity for the GALR2 receptor (IC50 of 0.24 nM) and a lower affinity for the GALR1 receptor (IC50 of 4.3 nM).
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Neuropeptide Y (human) free acid
0 ImagesCat. No.: HY-P10290CAS No.: 99575-89-0Neuropeptide Y (human) free acid is the deamidated form of Neuropeptide Y (human, rat, mouse) (HY-P0198). The amidation of Neuropeptide Y C-terminal tyrosine is critical for its function. Non-amidated Neuropeptide Y fails to elicit G protein signaling.
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Y4R agonist-2
0 ImagesCat. No.: HY-P3360CAS No.: 2757328-63-3Y4R agonist-2 is a Y4R agonist with a Ki of 0.033 nM.
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Npy4r Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09519Npy4r Rat Pre-designed siRNA Set A contains three designed siRNAs for Npy4r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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GR231118
0 ImagesCat. No.: HY-P1321CAS No.: 158859-98-4Synonyms: 1229U91; GW1229GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pKi of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC50=8.6; pKi=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pKi= 8.8).
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BIBO3304 free base
0 ImagesCat. No.: HY-120096CAS No.: 191868-13-0BIBO3304 free base is a nonpeptide neuropeptide Y Y1 receptor antagonist. BIBO3304 free base displays subnanomolar affinity for both the human and the rat Y1 receptor, with IC50 values of 0.38 nM and 0.72 nM, respectively. BIBO3304 free base significantly inhibits food intake induced by application of NPY or by fasting.
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Neuropeptide S(Rat) TFA
0 ImagesCat. No.: HY-P1438ANeuropeptide S(Rat) TFA is a potent endogenous neuropeptide S receptor (NSPR) agonist (EC50=3.2 nM). Neuropeptide S(Rat) TFA increases locomotor activity and wakefulness in mice. Neuropeptide S(Rat) TFA also reduces anxiety-like behavior in mice.
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Pancreatic Polypeptide, rat TFA
0 ImagesCat. No.: HY-P1532APurity: 98.05%Synonyms: Rat pancreatic polypeptide TFAPancreatic Polypeptide, rat TFA (Rat pancreatic polypeptide TFA) is a rat-derived Pancreatic Polypeptide. Pancreatic Polypeptide is a preferential agonist of NPYR4. Pancreatic Polypeptide, rat TFA protects cells against Streptozotocin (HY-13753)-induced DNA damage. Pancreatic Polypeptide, rat inhibits glucose-stimulated insulin secretion. Pancreatic Polypeptide, rat (TFA) can be used in diabetes-related research.
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M1145 TFA
0 ImagesCat. No.: HY-P1135AM1145 TFA, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 TFA shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 TFA has an additive effect on the signal transduction of galanin.
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Neuropeptide Y (22-36)
0 ImagesCat. No.: HY-P1818CAS No.: 119019-65-7Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y. Neuropeptide Y (22-36) acts on Y2 receptor and retains subnanomolar affinity for the Y2 receptor.
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NPY4R Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09517NPY4R Human Pre-designed siRNA Set A contains three designed siRNAs for NPY4R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Npy4r Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS09518Npy4r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npy4r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
