Pancreatic Polypeptide, rat TFA
Based on 1 Customer Validation
Pancreatic Polypeptide, rat TFA (Rat pancreatic polypeptide TFA) is a rat-derived Pancreatic Polypeptide. Pancreatic Polypeptide is a preferential agonist of NPYR4. Pancreatic Polypeptide, rat TFA protects cells against Streptozotocin (HY-13753)-induced DNA damage. Pancreatic Polypeptide, rat inhibits glucose-stimulated insulin secretion. Pancreatic Polypeptide, rat (TFA) can be used in diabetes-related research.
For research use only. We do not sell to patients.
- Formula: C195H298N58O57S·xC2HF3O2
- Molecular Weight:4398.87 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[2]|
NPY Y4 receptor |
In Vitro
Pancreatic Polypeptide, rat (0.1 μM-1 μM) TFA inhibits glucose-stimulated insulin secretion in rat BRIN BD11 β-cells, with no effect at lower concentrations or under basal glucose levels[2].
Pancreatic Polypeptide, rat (1 μM; 2 h) TFA completely protects rat BRIN BD11 β-cells against Streptozotocin (HY-13753)-induced DNA damage[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 4398.87 (free base)
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Formula C195H298N58O57S·xC2HF3O2
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SMILES
O=C(N1[C@@H](CCC1)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N2[C@@H](CCC2)C(N[C@@H](CCSC)C(N[C@@H](CC3=CC=C(C=C3)O)C(N4[C@@H](CCC4)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC8=CC=C(C=C8)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCCNC(N)=N)C(N9[C@@H](CCC9)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N.OC(C(F)(F)F)=O.[x]
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Synonyms
Rat pancreatic polypeptide TFA
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Sequence
Ala-Pro-Leu-Glu-Pro-Met-Tyr-Pro-Gly-Asp-Tyr-Ala-Thr-His-Glu-Gln-Arg-Ala-Gln-Tyr-Glu-Thr-Gln-Leu-Arg-Arg-Tyr-Ile-Asn-Thr-Leu-Thr-Arg-Pro-Arg-Tyr-NH2
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Sequence Shortening
APLEPMYPGDYATHEQRAQYETQLRRYINTLTRPRY-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
References
[1]. Kimmel JR, et al. Pancreatic polypeptide from rat pancreas. Endocrinology. 1984 May;114(5):1725-31.
[2]. Khan D, et al. Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival. Biochimica et biophysica acta. General subjects. 2017 Apr;1861(4):749-758. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pancreatic Polypeptide, rat TFA Related Classifications
HY-P1532A Related Classifications
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Keywords
- Pancreatic Polypeptide, rat
- Rat pancreatic polypeptide
- Neuropeptide Y Receptor
- DNA/RNA Synthesis
- NPYR4
- beta-cell
- C57BL/6 mouse islets
- glucose-stimulated insulin secretion
- pancreatic polypeptide
- neuropeptide Y receptor 4
- rat BRIN BD11 beta-cells
- human 1.1B4 beta-cells
- diabetes
- streptozotocin
- Inhibitor
- inhibitor
- inhibit