Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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1-(β-D-Xylofuranosyl)-N6-Isopentenyladenine
0 ImagesCat. No.: HY-1524011-(β-D-Xylofuranosyl)-N6-Isopentenyladenine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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7-Cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-ribofuranosyl)guanine
0 ImagesCat. No.: HY-152491CAS No.: 2763085-07-87-Cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-ribofuranosyl)guanine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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MMT-2'-O-Methyl adenosine (n-bz) CED phosphoramidite
0 ImagesCat. No.: HY-157339CAS No.: 2645354-88-5MMT-2'-O-Methyl adenosine (n-bz) CED phosphoramidite (compound 1) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies.
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Pseudouridine-13C,15N2
0 ImagesCat. No.: HY-W768571CAS No.: 2230887-15-5Pseudouridine-13C,15N2 is the 13C- and 15N-labeled Pseudouridine (HY-113061). Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia..
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2’-Bromo-2’-deoxy-5-fluorouridine
0 ImagesCat. No.: HY-154609CAS No.: 32791-82-52’-Bromo-2’-deoxy-5-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N7-Methyl-2’-beta-C-methyl guanosine
0 ImagesCat. No.: HY-152566N7-Methyl-2’-beta-C-methyl guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’,3’-Dideoxy-5-fluorocytidine
0 ImagesCat. No.: HY-152662CAS No.: 107036-62-42’,3’-Dideoxy-5-fluorocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3'-O-tert-Butyldimethylsilyl-5'-O-DMT-2'-deoxyadenosine
0 ImagesCat. No.: HY-154309CAS No.: 89947-86-43'-O-tert-Butyldimethylsilyl-5'-O-DMT-2'-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’(R)-C-Methyluridine
0 ImagesCat. No.: HY-152777CAS No.: 72159-54-7
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5’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-5-fluoro-uridine
0 ImagesCat. No.: HY-154555CAS No.: 160203-74-75’-O-Acetyl-2’,3’-dideoxy-2’,3’-didehydro-5-fluoro-uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N2-iBu-2’,3’-bis-O-TBDMS guanosine
0 ImagesCat. No.: HY-154235CAS No.: 79974-70-2N2-iBu-2’,3’-bis-O-TBDMS guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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A(5')ppp(5')(2'-OMeA)pG tetraammonium
0 ImagesCat. No.: HY-185611A(5')ppp(5')(2'-OMeA)pG tetraammonium is an anti-reverse Cap 1 reagent, used for co-transcriptional capping of in vitro transcribed mRNA. A(5')ppp(5')(2'-OMeA)pG tetraammonium does not compete with GTP to initiate transcription in the reaction system, thus effectively avoiding the reduction of the proportion of capped mRNA while maintaining a high GTP concentration. A(5')ppp(5')(2'-OMeA)pG tetraammonium can be used for efficient synthesis of high-quality in vitro transcribed mRNA.
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2’-Deoxy-N6-(4-methoxybenzyl)adenosine
0 ImagesCat. No.: HY-154457CAS No.: 157640-47-62’-Deoxy-N6-(4-methoxybenzyl)adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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6-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
![6-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine](https://file.medchemexpress.com/product_pic/hy-152443.gif "Click to View 6-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine Product Detail")
0 ImagesCat. No.: HY-1524436-Amino-3-(furan-2-yl)-4-methoxy-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N6-(5-Oxo-D-isoleucyl)-L-lysine
0 ImagesCat. No.: HY-180759CAS No.: 1307310-94-6N6-(5-Oxo-D-isoleucyl)-L-lysine is a nucleoside metabolite.
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1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione
0 ImagesCat. No.: HY-152676CAS No.: 83546-42-31-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-ethyl-2,4(1H,3H)-pyrimidinedione is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
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1,2-Di-O-acetyl-3,5-di-O-benzyl-D-xylofuranose
0 ImagesCat. No.: HY-154667CAS No.: 146986-45-01,2-Di-O-acetyl-3,5-di-O-benzyl-D-xylofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)uridine
![1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)uridine](https://file.medchemexpress.com/product_pic/hy-154526.gif "Click to View 1-(3’-O-[4,4’-Dimethoxytrityl]-alpha-L-threofuranosyl)uridine Product Detail")
0 ImagesCat. No.: HY-154526CAS No.: 325683-90-71-(3’-O-[4,4’-dimethoxytrityl]-alpha-L-threofuranosyl)uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)-5-methyluridine
0 ImagesCat. No.: HY-154384CAS No.: 2095417-53-95’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
