Phospholipase
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Phospholipase Related Products (235)
Related Products (235)
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Ro 31-4639
0 ImagesCat. No.: HY-115855CAS No.: 125131-65-9Ro 31-4639 is a potent phospholipase A2 inhibitor with an IC50 of 1.5 μM.
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AK106-001616
0 ImagesCat. No.: HY-127110CAS No.: 590416-75-4AK106-001616 is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) (IC50=3.8 nmol/L). AK106-001616 is able to reduce the production of prostaglandins (PG) E2 and leukotrienes (LT) B4 by stimulated cells. AK106-001616 can be used in the study of inflammatory diseases, neuropathic pain and pulmonary fibrosis.
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Fuzapladib potassium
0 ImagesCat. No.: HY-19151BCAS No.: 141284-74-4Synonyms: IS-741 potassiumFuzapladib (IS-741) potassium, an orally active leukocyte-function-associated antigen type 1 (LFA-1) activation inhibitor, is a leukocyte adhesion molecule. Fuzapladib potassium is also a phospholipase A2 (PLA2) inhibitor. Fuzapladib potassium exerts anti-inflammatory effects by inhibiting leukocyte migration into the inflammatory site.
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U-73122 (Standard)
0 ImagesCat. No.: HY-13419RCAS No.: 112648-68-7U-73122 (Standard) is the analytical standard of U-73122 (HY-13419). This product is intended for research and analytical applications. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50of 1-2.1 µM for PLC.
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Pyrrophenone (Standard)
0 ImagesCat. No.: HY-111376RCAS No.: 341973-06-6Pyrrophenone (Standard) is the analytical standard of Pyrrophenone (HY-111376). This product is intended for research and analytical applications. Pyrrophenone is a potent and specific cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 4.2 nM.
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BAPTA tetrapotassium (Standard)
0 ImagesCat. No.: HY-100168BRCAS No.: 73630-08-7BAPTA tetrapotassium (Standard) is the analytical standard of BAPTA tetrapotassium (HY-100168B). This product is intended for research and analytical applications. BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA tetrapotassium, as calcium indicator, has high selectivity against magnesium and calcium. BAPTA tetrapotassium is widely used as an intracellular buffer for investigating the effects of Ca2+ release from intracellular stores or influx via Ca2+-permeable channels in the plasma membrane. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
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SMases D-IN-1
0 ImagesCat. No.: HY-182413CAS No.: 849020-48-0SMases D-IN-1 is an inhibitor of SMase D (sphingomyelinase D) from Loxosceles (brown recluse spider), with a Ki value of 0.54 μM. SMases D-IN-1 inhibits the hydrolysis of sphingomyelin substrates by recombinant and native SMases D, reduces the binding ability of SMases D to human red blood cells, and prevents the shedding of glycophorin C from the surface of human red blood cells. SMases D-IN-1 partially inhibits Loxosceles venom-induced death of human keratinocytes and also suppresses systemic reactions triggered by Loxosceles venom. SMases D-IN-1 can be used in studies related to recluse spider envenomation.
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PLC thio-PIP2 trisodium
0 ImagesCat. No.: HY-172567PLC thio-PIP2 trisodium is an analog of naturally occurring PIP2. PLC thio-PIP2 trisodium can simulate the process of PIP2 being hydrolyzed by PLC in in vitro experiments, and then quantitatively analyze the activity of PLC by detecting the free thiol produced by hydrolysis.
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CCT129957 (Standard)
0 ImagesCat. No.: HY-111208RCAS No.: 883098-58-6CCT129957 (Standard) is the analytical standard of CCT129957 (HY-111208). This product is intended for research and analytical applications. CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM.
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MAFP (Standard)
0 ImagesCat. No.: HY-103334RCAS No.: 188404-10-6Synonyms: Methyl Arachidonyl Fluorophosphonate (Standard)MAFP (Standard) is the analytical standard of MAFP (HY-103334). This product is intended for research and analytical applications. MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase.
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Methyl γ-linolenyl fluorophosphonate
0 ImagesCat. No.: HY-158734CAS No.: 1370451-91-4Synonyms: MγLnFPMethyl γ-linolenyl fluorophosphonate (MγLnFP) is a close analog of a well-characterized, irreversible inhibitor of phospholipases, methyl arachidonyl fluorophosphonate (MAFP).
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Sphingolactone-24
0 ImagesCat. No.: HY-136994CAS No.: 881177-99-7Synonyms: Sph-24Sphingolactone-24 (Sph-24) is a selective and irreversible neutral sphingomyelinase (nSMase) inhibitor. Sphingolactone-24 has the potential for the research of acute lung injury.
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GK470
0 ImagesCat. No.: HY-120050CAS No.: 1621517-53-0GK470 (compound 28) is an inhibitor of group IVA cytosolic phospholipase A2 (GIVA cPLA2) with an IC50 of 300 nM in vesicle assays. GK470 has anti-inflammatory activity, inhibiting the release of arachidonic acid in SW982 fibroblast-like synoviocytes with an IC50 value of 0.6 μM. GK470 exhibits comparable anti-inflammatory effects to Methotrexate (HY-14519) in a preventive collagen-induced arthritis model and significantly reduces plasma PGE2 levels.
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VU0359595 (Standard)
0 ImagesCat. No.: HY-101293RCAS No.: 1246303-14-9Synonyms: CID-53361951 (Standard); ML-270 (Standard)VU0359595 (Standard) is the analytical standard of VU0359595 (HY-101293). This product is intended for research and analytical applications. VU0359595 (CID-53361951; ML-270) is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC50 of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC50 of 6.4 μM). VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases.
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DPPI-4,5-P2 ammonium
0 ImagesCat. No.: HY-172326CAS No.: 1902292-78-7DPPI-4,5-P2 ammonium is a sudstrate of Phosphoinositide-specific phospholipase C-δ1 (PI-PLC-δ1).
