2. Signaling Pathways
  3. Anti-infection
  4. RSV

RSV

Respiratory syncytial virus

RSV

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RSV (Respiratory syncytial virus) is a leading cause of acute respiratory infections. RSV can exploit host immunity and cause a strong inflammatory response that leads to lung damage and virus dissemination. There is a single RSV serotype with two major antigenic subgroups, A and B.

RSV is a non-segmented negative-sense single-stranded enveloped RNA virus that belongs to the family of Paramyxoviridae, genus Pneumovirus, subfamily Pneumovirinae. Its 10 genes encode 11 proteins since two overlapping open reading frames in the M2 mRNA yield two distinct matrix proteins, M2-1 and M2-2. The viral envelope contains three proteins, the G glycoprotein, the fusion (F) glycoprotein, and the small hydrophobic (SH) protein. The RSV virus comprises five other structural proteins, the large (L) protein, nucleocapsid (N), phosphoprotein (P), matrix (M), and M2-1, and two non-structural proteins (NS1 and NS2).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-161771
    JNJ-7184
    		Inhibitor
    JNJ-7184 is a non-nucleoside inhibitor of the RSV-Large (L) polymerase, with the pEC50 and pCC50 of 7.86 and 4.29 in Hela cells, respectively. JNJ-7184 prevents RSV replication and transcription by inhibiting initiation or early elongation.
    JNJ-7184
  • HY-104032R
    Ac-CoA Synthase-IN-1 (Standard)
    		Inhibitor
    Ac-CoA Synthase-IN-1 (Standard) is the analytical standard of Ac-CoA Synthase-IN-1 (HY-104032). This product is intended for research and analytical applications. Ac-CoA Synthase-IN-1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC50 of 0.6 μM. Ac-CoA Synthase-IN-1 inhibits the respiratory syncytial virus (RSV).
    Ac-CoA Synthase-IN-1 (Standard)
  • HY-158824B
    Asvasiran sodium scrambled negative control
    Asvasiran sodium scrambled negative control is the sequence scrambled negative control of Asvasiran sodium.
    Asvasiran sodium scrambled negative control
  • HY-158824
    Asvasiran
    Asvasiran is a siRNA that targets the respiratory syncytial virus (RSV) N gene and inhibits viral replication.
    Asvasiran
  • HY-124052
    AZ-27
    		Inhibitor
    AZ-27 is a respiratory syncytial virus (RSV) inhibitor. AZ-27 can differentially suppress various RSV polymerase activities at the promoter, thereby inhibiting the early stages of mRNA transcription and genome replication by targeting the promoter.
    AZ-27
  • HY-172452
    RSV L-protein-6
    		Inhibitor
    RSV L-protein-6 (Compound 19a) is a respiratory syncytial virus polymerase inhibitor, with an IC50 of 13 nM in SPA primer extensions enzymatic assay. RSV L-protein-6 can inhibit RSV replication in Hela cells.
    RSV L-protein-6
  • HY-120660
    AZD4316
    		Inhibitor
    AZD-4316 is a respiratory syncytial virus (RSV) L protein inhibitor. AZD-4316 has an inhibitory effect on RSV A subtypes (such as strain A2) and can effectively block viral replication in the early stage of infection (the viral entry stage). AZD-4316 is inactive when administered 12-24 hours after infection. AZD-4316 can be used for the research of RSV infection.
    AZD4316
  • HY-109004R
    Enzaplatovir (Standard)
    		Inhibitor
    Enzaplatovir (Standard) is the analytical standard of Enzaplatovir (HY-109004). This product is intended for research and analytical applications. Enzaplatovir (BTA-C585) is an orally bioavailable Inhibitor for respiratory syncytial virus (RSV) infection.
    Enzaplatovir (Standard)
  • HY-171983
    RSV-IN-13
    		Inhibitor
    RSV-IN-13 (compound 24) is a selective RSV fusion protein inhibitor with antiviral activity. RSV-IN-13 has an EC50 of 444.2 nM against RSV A2 strain and a CC90 of 23.7 μM in HepG2 cells. RSV-IN-13 can block the virus from entering host cells. RSV-IN-13 can be used to study RSV infection.
    RSV-IN-13
  • HY-121075R
    Alizarin complexone (Standard)
    		Inhibitor
    Alizarin complexone (Standard) is the analytical standard of Alizarin complexone (HY-121075). This product is intended for research and analytical applications. Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens.
    Alizarin complexone (Standard)
  • HY-12283R
    Rostafuroxin (Standard)
    		Inhibitor
    Rostafuroxin (Standard) is the analytical standard of Rostafuroxin. This product is intended for research and analytical applications. Rostafuroxin (PST 2238), a digitoxigenin derivative, is an orally active and potent Na+,K+-ATPase (ATP1A1) antognist. Rostafuroxin binds specifically to the ATP1A1 extracellular domain and blocks respiratory syncytial virus (RSV)-triggered EGFR Tyr845 phosphorylation. Rostafuroxin has antihypertensive and anti-RSV activity.
    Rostafuroxin (Standard)
  • HY-108002
    A 33903
    		Inhibitor
    A 33903 is a respiratory syncytial virus (RSV) replication inhibitor. A 33903 can be used for the research of RSV-infection.
    A 33903
  • HY-102038R
    PC786 (Standard)
    		Inhibitor
    PC786 (Standard) is the analytical standard of PC786 (HY-102038). This product is intended for research and analytical applications. PC786 is an inhaled respiratory syncytial virus (RSV) L protein polymerase inhibitor. PC786 demonstrates potent antiviral activity against RSV-A (IC50 <0.09 to 0.71 nM) and RSV-B (IC50, 1.3 to 50.6 nM).
    PC786 (Standard)
  • HY-B1724R
    Perflubron (Standard)
    		Inhibitor
    Perflubron (Standard) is the analytical standard of Perflubron. This product is intended for research and analytical applications. Perflubron (Perfluorooctyl bromide) is a contrast medium for magnetic resonance imaging and sonography. Perflubron can be emulsified with egg phospholipids (EYP) and shows exceptionally fast excretion characteristics.
    Perflubron (Standard)
  • HY-N12305
    4,5-O-Dicaffeoyl quinic acid methyl ester
    		Inhibitor
    4,5-O-Dicaffeoyl quinic acid methyl ester (compound 4), a dicaffeoylquinic acid, has potent antiviral activity against respiratory syncytial virus (RSV) with an IC50 of 0.63 μg/mL and a CC50 of 118.68 μg/mL.
    4,5-O-Dicaffeoyl quinic acid methyl ester
  • HY-181025
    JNJ-6231
    		Inhibitor
    JNJ-6231 is a long-acting RSV inhibitor.
    JNJ-6231
  • HY-109004AR
    (S)-Enzaplatovir (Standard)
    		Inhibitor
    (S)-Enzaplatovir (Standard) is the analytical standard of (S)-Enzaplatovir (HY-109004A). This product is intended for research and analytical applications. (S)-Enzaplatovir ((S)-BTA-C585) is the S-enantiomer of Enzaplatovir. (S)-Enzaplatovir shows antiviral activities with an EC50 of 56 nM for respiratory syncytial viral (RSV) (patent WO2011094823A1 compound 77).
    (S)-Enzaplatovir (Standard)
  • HY-168616
    CL-A3-7
    		Inhibitor
    CL-A3-7 is a virus-cell fusion inhibitor targeting the RSV F protein. It exerts its effect by blocking the interaction between the virus and the host IGF1R, effectively inhibiting infections of both wild-type RSV and the K394R variant. It is applicable to anti-RSV drug development and resistance-related research.
    CL-A3-7
  • HY-130627
    RSV/IAV-IN-2
    		Inhibitor
    RSV/IAV-IN-2 (compound 14c) is a potent and dual inhibitor of RSV/IAV. RSV/IAV-IN-2 has lesser cytotoxicity than the clinical agent, Ribavirin. RSV/IAV-IN-2 has the potential for the research of RSV and/or IAV infections.
    RSV/IAV-IN-2
  • HY-130626
    RSV/IAV-IN-1
    		Inhibitor
    RSV/IAV-IN-1 (compound 14e) is a potent and dual inhibitor of RSV/IAV. RSV/IAV-IN-1 has lesser cytotoxicity than the clinical agent, Ribavirin. RSV/IAV-IN-1 has the potential for the research of RSV and/or IAV infections.
    RSV/IAV-IN-1
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity