Sodium Channel
Na channels; Na+ channels
Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.
Sodium Channel Isoform Specific Products
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Sodium Channel
(629)
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Nav1.1
(12)
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Nav1.2
(17)
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Nav1.3
(15)
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Nav1.4
(15)
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Nav1.5
(27)
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Nav1.6
(13)
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Nav1.7
(63)
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Nav1.8
(42)
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Nav1.9
(3)
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All Product Categories
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Sodium Channel Inhibitors
(627)
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Sodium Channel Agonists
(10)
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Sodium Channel Antagonists
(30)
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Sodium Channel Activators
(35)
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Sodium Channel Modulators
(30)
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Sodium Channel Controls
(5)
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Sodium Channel Ligands
(3)
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Sodium Channel Related Products (810)
Related Products (810)
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Antibodies (9)
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Related Compound Screening Libraries (1)
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Sodium Channel Isoform Comparison
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Jasmolin II
0 ImagesCat. No.: HY-W740651CAS No.: 1172-63-0Jasmolin II is an insecticide targeting voltage-gated sodium channels in insects. Jasmolin II leads to neuronal hyperexcitation and insect paralysis. Jasmolin II is promising for research of agricultural pests.
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Etidocaine
0 ImagesCat. No.: HY-B2080CAS No.: 36637-18-0Synonyms: EDCEtidocaine (EDC) is a long aminoamide local anesthetic.
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Nav1.8-IN-13
0 ImagesCat. No.: HY-161572CAS No.: 2785391-79-7Nav1.8-IN-13 (compound 16) is a Nav1.8 inhibitor (pIC50=7.9).
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GpTx-1
0 ImagesCat. No.: HY-P1681CAS No.: 1661050-12-9GpTx-1 is a peptide-based NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. GpTx-1 demonstrates potent inhibitory activity against the NaV1.7 channel with an IC50 value of 10 nM, while exhibiting excellent selectivity for NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM), showing >20-fold and >950-fold selectivity respectively.
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Ropivacaine-d7 hydrochloride
0 ImagesCat. No.: HY-B0563BSCAS No.: 1217667-10-1Ropivacaine-d7 hydrochloride is a deuterium labeled Ropivacaine (hydrochloride) (HY-B0563B). Ropivacaine hydrochloride is a potent sodium channel blocker and blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibrese. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is widely used for neuropathic pain management in vivo.
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BI 1265162
0 ImagesCat. No.: HY-161085CAS No.: 3042822-44-3BI 1265162 is a potent inhibitor of endothelial sodium channel (ENaC) that plays an important role in cystic fibrosis research.
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VGSC blocker-1
0 ImagesCat. No.: HY-126005CAS No.: 2230472-55-4
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Jingzhaotoxin-IX
0 ImagesCat. No.: HY-P5771Jingzhaotoxin-IX, a C-terminally amidated peptide composed of 35 amino acid residues, is a neurotoxin. Jingzhaotoxin-IX inhibits voltage-gated sodium channels (both tetrodotoxin-resistant and tetrodotoxin-sensitive isoforms) and Kv2.1 channel. Jingzhaotoxin-IX has no effect on delayed rectifier potassium channel Kv1.1, 1.2 and 1.3.
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Articaine hydrochloride (Standard)
0 ImagesSynonyms: Hoe-045 (Standard)Articaine (Hoe-045) hydrochloride (Standard) is the analytical standard of Articaine hydrochloride (HY-B0516). This product is intended for research and analytical applications. Articaine (Hoe-045) hydrochloride is a selective inhibitor of voltage-gated sodium channels (such as rNav1.4, hNav1.7, and rNav1.8), with an IC50 of 15.8 μM for open-state Na+ channels, and IC50 of 40.6 μM and 378 μM for inactivated and resting-state Na+ channels, respectively. Articaine hydrochloride exerts local anesthetic activity by inhibiting Na+ influx to block nerve impulse conduction, and can also inhibit NF-κB activation and NLRP3 inflammasome pathways, exhibiting anti-inflammatory function. Articaine hydrochloride can be used in the study of dental local anesthesia and inflammatory-related diseases (such as acute kidney injury).
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mHuwentoxin-IV
0 ImagesCat. No.: HY-P5868mHuwentoxin-IV is a naturally modified Huwentoxin-IV (HY-P1220). mHuwentoxin-IV inhibits tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels of dorsal root ganglion neurons with an IC50 of 54.16 nM. mHuwentoxin-IV inhibition of tetrodotoxin-sensitive sodium channels is not reversed by strong depolarization voltages.
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Jingzhaotoxin-III
0 ImagesCat. No.: HY-P1219CAS No.: 925463-91-8Synonyms: β-TRTX-Cj1αJingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype.
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Anti-SLC34A2 (Lifastuzumab)-MC-Vc-PAB-SN38
0 ImagesCat. No.: HY-171738Anti-SLC34A2 (Lifastuzumab)-MC-Vc-PAB-SN38 is an antibody-drug conjugate (ADC) consisting of the humanized anti-SLC34A2 (sodium-dependent phosphate transporter 2) antibody Lifastuzumab (HY-P99970) conjugated to the linker Mc-VC-PAB and the topoisomerase I inhibitor SN38 (HY-13704). The ADC toxic molecule and linker part are Mc-VC-PAB-SN38 (HY-131057). Anti-SLC34A2 (Lifastuzumab)-MC-Vc-PAB-SN38 can be used in cancer research.
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Antho-Rwamide II
0 ImagesCat. No.: HY-P10595CAS No.: 118904-15-7Antho-Rwamide II is a neuropeptide that can be isolated from the sea anemone Anthopleura elegantissima. Antho-Rwamide II can induce contraction of the endothelial muscles of the sea anemone and participate in neurotransmission. Antho-Rwamide II can be used to explore the function of the nervous system in invertebrates.
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Aneratrigine hydrochloride
0 ImagesCat. No.: HY-156596ACAS No.: 2097163-75-0Aneratrigine hydrochloride is a selective Nav1.7 inhibitor with an IC50 of 19 nM. Aneratrigine hydrochloride is applicable for pain-related research.
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Transcainide
0 ImagesCat. No.: HY-123427CAS No.: 88296-62-2Synonyms: R 54718Transcainide (R 54718) is an orally active antiarrhythmic agent.
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NHE3-IN-3
0 ImagesCat. No.: HY-151360CAS No.: 543734-50-5NHE3-IN-3 (Compound 1) is a Na+/H+ exchanger isoform 3 (NHE3) inhibitor with pIC50 of 6.2 and 6.6 against human and rat NHE3, respectively. NHE3-IN-3 shows high (98%) oral bioavailability in Sprague–Dawley rats.
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Hainantoxin-III
0 ImagesCat. No.: HY-P5180CAS No.: 1809149-40-3Jingzhaotoxin-V is a peptide that inhibits potassium currents in Xenopus laevis oocytes with an IC50 value of 604.2 nM. Jingzhaotoxin-V also inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodium currents in rat dorsal root ganglion neurons with IC50 values of 27.6 and 30.2 nM, respectively.
