Thyroid Hormone Receptor
THR
Thyroid hormone receptor is a member of the nuclear receptor superfamily that shuttles between the cytosol and nucleus. Thyroid hormone receptors are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Thyroid hormone receptors are encoded by two genes, one for TRα and another for TRβ, which encode the major isoforms of TR, including TRα1, TRα2, TRβ1, and TRβ2. The thyroid hormone receptors mediate the pleiotropic activities of the thyroid hormone (T3) in growth, development, and differentiation and in maintaining metabolic homeostasis.
Thyroid hormone receptors are zinc finger transcription factors in the erbA superfamily that bind DNA at specific response element sequences (thyroid hormone response elements, TREs) and activate gene expression in response to thyroid hormone (T3). Thyroid hormone receptors have been shown to bind DNA as monomers, homodimers, or heterodimers with another erbA superfamily member, the retinoid X receptor (RXR).
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Thyroid Hormone Receptor Inhibitors
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Thyroid Hormone Receptor Ligand
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Thyroid Hormone Receptor Related Products (188)
Related Products (188)
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Antibodies (5)
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Reverse T3 (Standard)
0 ImagesCat. No.: HY-W010696RCAS No.: 5817-39-0Synonyms: 3′,5′,3-Triiodothyronine (Standard)Reverse T3 (Standard) is the analytical standard of Reverse T3. This product is intended for research and analytical applications. Reverse T3 is a thyroid hormone that can be generated by deiodination of the prohormone thyroxine. Reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes.
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Thyroxine methyl ester
0 ImagesCat. No.: HY-131499CAS No.: 32180-11-3Thyroxine methyl ester is a Thyroxine derivative.
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L-Thyroxine-13C6
0 ImagesCat. No.: HY-18341S2CAS No.: 720710-30-5L-Thyroxine-13C6 is the 13C labeled L-Thyroxine. L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
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Omzotirome
0 ImagesSynonyms: TRC-150094Omzotirome (TRC150094), a functional analog of iodothyronines, can be used for the research of hyperlipidaemia (WO2008149379).
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THR-β agonist 2
0 ImagesTHR-β agonist 2 is a potent agonist of THR-β. THR-β agonist 2 has the potential for the research of metabolic diseases such as obesity, hyperlipidemia, hypercholesterolemia, diabetes and other conditions such as steatosis and non-alcoholic steatohepatitis (NASH), atherosclerosis and other related conditions and diseases (extracted from patent WO2021121210A1, compound 3).
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Methimazole-d3
0 ImagesSynonyms: Thiamazole-d3Methimazole-d3 is a deuterium labeled Methimazole (HY-B0208). Methimazole (Thiamazole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity.
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T4-ATA (S-isomer)
0 ImagesT4-ATA S-isomer is the S-isomer of T4-ATA, which is the active form of the thyroid hormone.
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(E)-Octinoxate-d3
0 ImagesCat. No.: HY-W713284CAS No.: 2734919-82-3Synonyms: (E)-Octyl methoxycinnamate-d3Octinoxate-d3 is the deuterium labeled Octinoxate (HY-B1234). Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka. Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment. Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes. Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo.
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Glp-Asn-Pro-AMC
0 ImagesGlp-Asn-Pro-AMC is an inhibitor of thyrotropin-releasing hormone degrading enzyme (TRH-DE) with a Ki value of 0.97 μM.
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Thyroxine sulfate (Standard)
0 ImagesSynonyms: T4 Sulfate (Standard)Thyroxine sulfate (Standard) is the analytical standard of Thyroxine sulfate. This product is intended for research and analytical applications. Thyroxine sulfate is a thyroid hormone metabolite.
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Liothyronine-13C9,15N
0 ImagesCat. No.: HY-A0070AS1CAS No.: 1213569-04-0Synonyms: Triiodothyronine-13C9,15N; 3,3',5-Triiodo-L-thyronine-13C9,15N; T3-13C9,15NLiothyronine-13C9,15N is the 13C and 15N labeled Liothyronine. Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
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Liothyronine-13C6-1
0 ImagesSynonyms: Triiodothyronine-13C6-1; 3,3',5-Triiodo-L-thyronine-13C6-1; T3-13C6-1Liothyronine-13C6-1 is a 13C-labeled Liothyronine. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
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THR-β agonist 1
0 ImagesTHR-β Agonist 1 is a potent and selective agonist of THRβ. Thyroid hormone receptor mediates the physiological activity of thyroid hormones which plays a key role in normal growth and development of the body and in maintaining metabolic balance. THR-β Agonist 1 has the potential for the research of thyroid hormone receptor-related diseases (extracted from patent WO2021104288A1, compound 2).
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pTH (44-68) (human)
0 ImagesCat. No.: HY-P4697CAS No.: 64421-69-8pTH (44-68) (human) is apTH ((Human parathyroid hormone) fragment.
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Liothyronine hydrochloride
0 ImagesSynonyms: Triiodothyronine hydrochloride; 3,3',5-Triiodo-L-thyronine hydrochloride; T3 hydrochlorideLiothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively.
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Parathyroid hormone (1-34) (rat) acetate
0 ImagesCat. No.: HY-P2279APurity: 99.87%Parathyroid hormone (1-34) (rat) (acetate) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis.
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Progoitrin
0 ImagesProgoitrin is an orally active glucosinolate. As the precursor of goitrin (HY-N0224A), an antithyroid compound, progoitrin releases goitrin via hydrolysis by myrosinase or gastrointestinal glucosidase. Progoitrin converts to goitrin in vivo and exerts antithyroid activity by inhibiting the accumulation of radioactive iodine in the thyroid gland. Progoitrin can be used in the research of Graves' disease (thyrotoxicosis).
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Metamizole
0 ImagesCat. No.: HY-148147CAS No.: 50567-35-6Synonyms: Dipyrone free base; MethamizoleMetamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity.
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Calcitonin, eel TFA
0 ImagesCat. No.: HY-P1463APurity: 99.91%Synonyms: Thyrocalcitonin eel TFACalcitonin, eel TFA is the thyroid hormone peptide that contributes to the regulation of calcium homeostasis, widely used in the research of postmenopausal osteoporosis.
