Tyrosinase

Related Products

Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.

Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.

Tyrosinase Related Products (303)
Antibodies (9)

By Effects:	Inhibitors (261) Degrader (1) Substrates (6) Antagonist (1) Activators (10) Modulator (1) Inducer (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-N19646

[8]-Dehydrogingerdione	Inhibitor
[8]-Dehydrogingerdione is a Hydroxyphenylalkanone. [8]-Dehydrogingerdione can be isolated from the seeds of Aframomum melegueta and the rhizomes of Curcuma xanthorrhia. [8]-Dehydrogingerdione acts as an inhibitor of α-glucosidase and Tyrosinase, with an IC₅₀ value of 19.5 μM against α-glucosidase and an approximate IC₅₀ value of 100 μM against tyrosinase. [8]-Dehydrogingerdione can be used in diabetes-related research.

HY-162894

Tyrosinase-IN-37	Inhibitor
Tyrosinase-IN-37 (Compound 3c) is an effective Tyrosinase inhibitor with an IC₅₀ of 1.02 μM, exhibiting 14 times the inhibitory effect of kojic acid (Kojic acid, HY-W050154), which has an IC₅₀ of 14.74 μM. Tyrosinase-IN-37 can effectively prevent the browning of Rosa roxburghii. Additionally, Tyrosinase-IN-37 can also inhibit browning that is not caused by Tyrosinase.

HY-131327

Azo-resveratrol	Inhibitor
Azo-resveratrol, an Azo compound, inhibits Mushroom tyrosinase (IC₅₀=36.28 μM).

HY-169328

Tyrosinase-IN-39	Inhibitor
Tyrosinase-IN-39 (compound 5r) is a competitive tyrosinase inhibitor with the IC₅₀ of 6.4 μM and can be used for study of skin diseases.

HY-168302

BTK ligand 10	Degrader
BTK ligand 10 is the ligand of BTK. BTK ligand 10 can be used to synthesize NX-2127 (HY-153220).

HY-161241

Tyrosinase-IN-23	Inhibitor
Tyrosinase-IN-23 (Compd 11m) is a tyrosinase inhibitor with an IC₅₀ of 55.39±4.93 µM. Tyrosinase-IN-23 can be used for research of melanin biosynthesis.

HY-N1750R

3-(2,4-Dihydroxyphenyl)propanoic acid (Standard)	Inhibitor
Garenoxacin (Standard) is the analytical standard of Garenoxacin. This product is intended for research and analytical applications. Garenoxacin (BMS284756) is an orally active quinolone antibiotic and has a broad spectrum of activity against a wide array of gram-positive and gram-negative bacteria, anaerobes, and fastidious organisms.

HY-W099579R

Kojic acid dipalmitate (Standard)	Inhibitor
Kojic acid dipalmitate (Standard) is the analytical standard of Kojic acid dipalmitate. This product is intended for research and analytical applications. Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research.

HY-135743

Apovincamine	Inhibitor
Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity.

HY-124827

Tec-IN-1	Inhibitor
Tec-IN-1 (Compound 21) is a Tec inhibitor (IC₅₀s of 11.7 μM). Tec-IN-1 inhibits Tec-mediated tyrosine phosphorylation of FGF2, and inhibits FGF2 secretion from cells.

HY-161969

Tyrosinase-IN-34	Inhibitor
Tyrosinase-IN-34 (compound 5a) is a human tyrosinase inhibitor (IC₅₀: 3.5 μM) with the potential to control melanogenesis and pigmentation.

HY-161612

Mycosporine 2 glycine	Inhibitor
Mycosporine 2 glycine is an anti-inflammatory agent and TYRP1 inhibitor. Mycosporine 2 glycine inhibits the expression of inflammatory genes and reduces nitric oxide production. Mycosporine 2 glycine binds tightly to the active pocket of TYRP1 and inhibits the activity of melanogenesis-related enzymes. Mycosporine 2 glycine can be used in the research of hyperpigmentation and inflammation-related diseases.

HY-173223

Tyrosinase-IN-41	Inhibitor
Tyrosinase-IN-41 (compound 7) is a Tyrosinase inhibitor, with an IC₅₀ of 9.45 μM.

HY-W017212S

Methyl cinnamate-d₇	Inhibitor
Methyl cinnamate-d₇ is deuterated labeled Methyl cinnamate (HY-W017212). Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway.

HY-W017212R

Methyl cinnamate (Standard)	Inhibitor
Methyl cinnamate (Methyl 3-phenylpropenoate), an active component of Zanthoxylum armatum, is a widely used natural flavor compound. Methyl cinnamate (Methyl 3-phenylpropenoate) possesses antimicrobial activity and is a tyrosinase inhibitor that can prevent food browning. Methyl cinnamate (Methyl 3-phenylpropenoate) has antiadipogenic activity through mechanisms mediated, in part, by the CaMKK2-AMPK signaling pathway.

HY-W015309R

Decanoic acid (Standard)	Inhibitor
Decanoic acid (Standard) is the analytical standard of Decanoic acid. This product is intended for research and analytical applications. Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces tyrosinase activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy.

HY-141555

5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione	Inhibitor
5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione is a weak inhibitor for snake venom and human recombinant phosphodiesterase 1 with IC₅₀ of 429 and 467 μM. 5,5′-(1,3-Propanediyl)bis-1,3,4-oxadiazole-2(3H)-thione inhibits mushroom tyrosinase weakly, with K_i of 1.9 μM.

HY-W013673R

2,3-Diaminopropionic acid hydrochloride (Standard)	Inhibitor
2,3-Diaminopropionic acid hydrochloride is the precursor of antibiotics and the siderophore staphyloferrin B. 2,3-Diaminopropionic acid hydrochloride is the inhibitor for polyphenoloxidase (PPO).

HY-W015782R

4-Ethylresorcinol (Standard)	Substrate
4-Ethylresorcinol (Standard) is the analytical standard of 4-Ethylresorcinol (HY-W015782). This product is intended for research and analytical applications. 4-Ethylresorcinol is a derivative of resorcinol and can serve as a substrate for tyrosinase. 4-Ethylresorcinol has anti-hyperpigmentation and antioxidant effects and can inhibit melanin synthesis. 4-Ethylresorcinol has potential whitening value.

HY-123898

Cepharadione B	Inhibitor
Cepharadione B (compound 22) is a natural compound isolated from the leaves of Piper sanctum. Cepharadione B is a tyrosinase inhibitor with an IC₅₀ value of 170 μM, and inhibits cell growth in A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cells.

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Tyrosinase

Tyrosinase

Tyrosinase Related Products (303)

Antibodies (9)

Tyrosinase Related Products (303):