Tyrosinase
Tyrosinase is a copper-containing metalloprotein belonging to the type-3 copper protein family, together with haemocyanins and catechol oxidases. Tyrosinases are the catalysts in mammals responsible for the formation of melanin in skin and hair color, as well as browning in fruit and vegetables following cell damage.
Tyrosinases are found in various prokaryotes as well as in plants, fungi, arthropods, and mammals and are responsible for pigmentation, wound healing, radiation protection, and primary immune response. Tyrosinases perform two sequential enzymatic reactions: hydroxylation of monophenols and oxidation of diphenols to form quinones which polymerize spontaneously to melanin. In plants, sponges, and many invertebrates, tyrosinases are important for wound healing and primary immune responses; in arthropods, they play a role in sclerotization, and in bacteria, tyrosinases protect DNA from UV damage.
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Tyrosinase Inhibitors
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Tyrosinase Antagonist
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Tyrosinase Activators
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Tyrosinase Modulator
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Tyrosinase Inducer
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Tyrosinase Degrader
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Tyrosinase Substrates
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Tyrosinase Ligand
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Tyrosinase Related Products (325)
Related Products (325)
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Antibodies (9)
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Puerarin 6''-O-Xyloside (Standard)
0 ImagesCat. No.: HY-N2135RCAS No.: 114240-18-5Puerarin 6''-O-Xyloside (Standard) is the analytical standard of Puerarin 6''-O-Xyloside (HY-N2135). This product is intended for research and analytical applications. Puerarin 6''-O-Xyloside is one of the major iso-flavones found in P. lobata. Puerarin 6''-O-Xyloside inhibits cancer cells proliferation, induces apoptosis by upregulating cleaved caspase-3, 7, 9, Bax and downregulating Bcl-2 levles and inhibits tumor growth in mice. Puerarin 6''-O-Xyloside has anti-osteoporotic activity in ovariectomized mice. Puerarin 6''-O-Xyloside inhibits mushroom tyrosinase with an IC50 of 513.8 μM. Puerarin 6''-O-Xyloside can be used for the research of human lung carcinoma, osteoporosis, melanosis and melanomar.
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Glutathione trisulfide TFA
0 ImagesCat. No.: HY-160906APurity: 99.08%Synonyms: GSSSG TFAGlutathione trisulfide TFA (GSSSG TFA) is an orally active, blood-brain barrier permeable neuroprotective agent. Glutathione trisulfide TFA inactivates intracellular tyrosinase, regulates the expression of Cars2, Cbs, MITF and TYR, inhibits α-MSH (HY-P0252)-induced melanogenesis, and restores intracellular persulfide levels reduced by α-MSH. Glutathione trisulfide TFA scavenges free radicals, quenches ROS, reduces Paclitaxel (HY-B0015)-induced superoxide production, upregulates the expression of antioxidant protein genes, and inhibits oxidative stress-induced cell death. Glutathione trisulfide TFA promotes ERK1/2 activation, prevents NF-κB p65 activation, inhibits TAK1 phosphorylation, reduces pro-inflammatory cytokine expression, and blocks microglial activation. Glutathione trisulfide TFA can be used in research related to dry age-related macular degeneration, inflammation-associated eye diseases, Alzheimer's disease, Parkinson's disease, etc.
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Allamandicin
0 ImagesCat. No.: HY-N2839CAS No.: 51838-83-6Allamandicin is an iridoid lactones. Allamandicin can be isolated from the roots of Allamanda cathartica. Allamandicin is an inhibitor of tyrosinase.
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Tyrosinase (192-200), human mouse
0 ImagesCat. No.: HY-P3742CAS No.: 170294-35-6Tyrosinase (192-200), human mouse is a HLA-B*4403-restricted tyrosinase epitope with affinity for HLA-B4403 and HLA-B4402. Tyrosinase (192-200), human mouse binds to HLA-B*4403 to form a complex, which is recognized by the autologous cytotoxic T lymphocyte clone 22/31 derived from melanoma. Tyrosinase (192-200), human mouse binds to HLA-B4402 to form a complex, which is recognized by the CTL clone 329B/5 derived from healthy HLA-B4402 donors. Tyrosinase (192-200), human mouse is applicable to melanoma-related research.
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Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside
0 ImagesCat. No.: HY-N17896CAS No.: 123564-49-8Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is a lignan compound and a melanogenesis inhibitor with low cytotoxicity. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is isolable from the stem bark of Acer buergerianum (Acer buergerianum). Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside effectively inhibits the melanogenesis process in α-MSH (HY-P0252)-stimulated B16 melanoma cells. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside exhibits extremely high safety towards normal cells, and serves as an ideal tool molecule for studying melanoma mechanisms and developing related whitening products.
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LY2457546
0 ImagesCat. No.: HY-107144CAS No.: 908265-94-1LY2457546 is a potent and orally active multi-targeted anti-angiogenic tyrosine kinases inhibitor. LY2457546 demonstrates potent activity against targets that include VEGFR2, PDGFRβ, FLT-3, Tie-2 and members of the Eph family of receptors. LY2457546 can be used for the research of cancer, such as leukemia.
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Delphinidin-3-O-galactoside chloride (Standard)
0 ImagesCat. No.: HY-N6606RCAS No.: 28500-00-7Delphinidin-3-O-galactoside chloride (Standard) is the analytical standard of Delphinidin-3-O-galactoside chloride (HY-N6606). This product is intended for research and analytical applications. Delphinidin-3-O-galactoside chloride is an anthocyanin found in abbiteye blueberry. Delphinidin-3-O-galactoside chloride show inhibitory activitiesagainst α-glucosidase with an IC50 of 68.33 μM, and tyrosinase with an IC50 of 34.14 μM. Delphinidin-3-O-galactoside chloride attenuates HO-1 and HSP70 messenger RNA down-regulation, suppresses cytotoxicity, reduces endoplasmic reticulum stress responses, scavenges free radicals, reduces intracellular triglyceride levels and lipid droplet accumulation. Delphinidin-3-O-galactoside chloride can be used for the researches of diabesity, melanoma and inflammation.
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JAK3-IN-18
0 ImagesCat. No.: HY-174999CAS No.: 2914873-59-7JAK3-IN-18 is an orally active JAK3 and TEC inhibitor, with IC50s of 0.5391 nM and 12.40 nM, respectively. JAK3-IN-18 demonstrates outstanding selectivity over AK1, AK2, and TYk2, with selectivity ratios exceeding 10,000-fold. JAK3-IN-18 demonstrates excellent therapeutic efficacy in the experimental autoimmune encephalomyelitis (EAE) mouse model. JAK3-IN-18 can be used for the study of multiple sclerosis.
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Trifolirhizin (Standard)
0 ImagesTrifolirhizin (Standard) is the analytical standard of Trifolirhizin. This product is intended for research and analytical applications. Trifolirhizin is a pterocarpan flavonoid isolated from the roots of Sophora flavescens. Trifolirhizin possesses potent tyrosinase inhibitory activity with an IC50 of 506 μM. Trifolirhizin exhibits potential anti-inflammatory and anticancer activities.
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Persiconin
0 ImagesCat. No.: HY-N3091CAS No.: 28978-03-2Persiconin is a tyrosinase Inhibitor. Persiconin can be isolated from Prunus persica. Persiconin has tyrosinase inhibitory activity of 46% at 500 μM. Persiconin can be used in whitening research.
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1,2,4,6-Tetra-O-galloyl-β-D-glucose
0 ImagesCat. No.: HY-N15572CAS No.: 84297-49-41,2,4,6-Tetra-O-galloyl-β-D-glucose is an acetylcholinesterase inhibitor with an IC50 of 1.5 μM against human targets. 1,2,4,6-Tetra-O-galloyl-β-D-glucose inhibits the aggregation of amyloid-β. 1,2,4,6-Tetra-O-galloyl-β-D-glucose exhibits anti-herpesvirus activity against both HSV-1 and HSV-2 in vitro. 1,2,4,6-Tetra-O-galloyl-β-D-glucose possesses superoxide dismutase-like antioxidant activity, and also inhibits tyrosinase and hyaluronidase. 1,2,4,6-Tetra-O-galloyl-β-D-glucose can be used in studies related to Alzheimer's disease, herpesvirus infection and antioxidation.
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Moracin M 3'-O-β-D-glucopyranoside
0 ImagesCat. No.: HY-N21974CAS No.: 152041-26-4Moracin M 3'-O-β-D-glucopyranoside is a natural product with multiple activities such as hypoglycemic and antitumor effects. Moracin M 3'-O-β-D-glucopyranoside acts as an inhibitor of mushroom tyrosinase with an IC50 of 127.5 μM, and also functions as an inhibitor of soluble epoxide hydrolase with an IC50 of 7.7 μM. Moracin M 3'-O-β-D-glucopyranoside can be used in studies related to hyperglycemia and skin tumors.
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2-Ketoglutaric acid-13C2
0 ImagesCat. No.: HY-W013636S4CAS No.: 123953-28-6Synonyms: Alpha-Ketoglutaric acid-13C22-Ketoglutaric acid-13C2 (Alpha-Ketoglutaric acid-13C2) is a 13C labeled 2-Ketoglutaric acid (HY-W013636). 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM).
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Taxiphyllin
0 ImagesCat. No.: HY-N1170CAS No.: 21401-21-8Synonyms: (2R)-TaxiphyllinTaxiphyllin (2R-Taxiphyllin) is a plant cyanogenic glycoside, which exhibits inhibitory activity for tyrosinase. Taxiphyllin exhibits cytotoxicity in BRL-3A cellls with an IC50 of 18.75 μm and antimicrobial activities against Staphylococcus aureus with an EC50 of 0.96 μM.
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Kurarinol
0 ImagesCat. No.: HY-122933CAS No.: 855746-98-4Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase.
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MHY884
0 ImagesCat. No.: HY-116145CAS No.: 1393371-35-1MHY884 is a tyrosinase inhibitor that suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. MHY884 suppresses oxidative stress in the melanoma cells and attenuates UVB-induced oxidative stress, resulting in reduced NF-κB activity in irradiated mice. MHY884 is promising for research of UVB-induced skin damage.
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2,3-Diaminopropionic acid
0 Images2,3-Diaminopropionic acid is the precursor of antibiotics and the siderophore staphyloferrin B. 2,3-Diaminopropionic acid is the inhibitor for polyphenoloxidase (PPO).
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hTYR/AbTYR-IN-1
0 ImageshTYR/AbTYR-IN-1 (Compound 7) is a hTYR/AbTYR dual inhibitor, with IC50s of 5.4 μM and 3.52 μM for hTYR and AbTYR respectively.
