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Beta-lactamase Related Products (198)
Related Products (198)
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Sulopenem (Standard)
0 ImagesCat. No.: HY-105284RCAS No.: 120788-07-0Synonyms: CP-70429 (Standard)N-Acetylneuraminic acid (Standard) is the analytical standard of N-Acetylneuraminic acid. This product is intended for research and analytical applications. N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia.
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ZN148
0 ImagesCat. No.: HY-176565CAS No.: 2190527-04-7ZN148 is a zinc-chelating synthetic metallo-β-lactamase (MBL) inhibitor which attenuates MBL-mediated carbapenem resistance. ZN148 can restore the in vitro clinical susceptibility to carbapenems in >98% of a large international collection of MBL-producing clinical Enterobacterales strains. ZN148 can be utilized in research on anti MBL-producing bacteria.
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β-Lactamase-IN-8
0 ImagesCat. No.: HY-146075CAS No.: 1929555-36-1β-Lactamase-IN-8 (compound 20) is a potent and oral bioavailable broad-spectrum cyclic boronate β-lactamase inhibitor. β-Lactamase-IN-8 can be used for researching antibacteria.
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β-Lactamase-IN-7
0 ImagesCat. No.: HY-144100CAS No.: 2419903-21-0β-Lactamase-IN-7 (compound 14) is a potent VIM-Type metallo-β-lactamase inhibitor, with Kis of 1.26 μM and 0.54 μM for VIM-1 and VIM-4, respectively. β-Lactamase-IN-7 can effectively inhibit Klebsiella pneumoniae.
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Pilabactam
0 ImagesCat. No.: HY-147349ACAS No.: 2410688-60-5Synonyms: ANT3310Pilabactam (ANT3310) is a broad-spectrum covalent Serine β-Lactamase inhibitor, with IC50 values ranging from 1 nM to 175 nM (a panel of Serine β-Lactamase). Pilabactam potentiates activity of β-lactam antibiotics against Carbapenem-Resistant Enterobacterales (CRE) and Acinetobacter baumannii (CRAB). Pilabactam can be used in the research of bacterial infection.
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Metallo-β-lactamase-IN-11
0 ImagesCat. No.: HY-155504CAS No.: 3038740-18-7Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC50=45 µM). Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance.
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β-Lactamase-IN-5
0 ImagesCat. No.: HY-139779CAS No.: 1463521-39-2β-Lactamase-IN-5 is a β-lactamase inhibitor extracted from patent WO2013149121A1, compound 720. β-Lactamase-IN-5 can be used for the research of bacterial infections.
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β-Lactamase-IN-6
0 ImagesCat. No.: HY-115872CAS No.: 2326468-84-0β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.
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GT-055 free base
0 ImagesCat. No.: HY-187939CAS No.: 2092930-66-8Synonyms: LCB18-055 free baseGT-055 free base (LCB18-055 free base) is a broad-spectrum β-lactamase inhibitor and penicillin-binding protein 2 (PBP2) inhibitor. GT-055 free base inactivates β-lactamase, protects GT-1 from hydrolysis, and binds tightly to PBP2, thereby inhibiting cell wall biosynthesis. GT-055 free base can be used for research on bacterial infections.
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ANT2681
0 ImagesCat. No.: HY-176519CAS No.: 2270184-16-0ANT2681 is a potent NDM inhibitor with a Ki value of 0.04 μM against NDM-1. ANT2681 also inhibits other MBLs, such as VIM-1 and IMP-1 with Ki values of 0.63 μM and 3.81 μM, respectively. ANT2681 can be used in combination with Meropenem (HY-13678) to inhibit infections caused by NDM-producing Enterobacteriaceae.
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Avibactam-13C5,15N sodium
0 ImagesCat. No.: HY-14879S7Synonyms: NXL-104-13C5,15N sodium
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β-Lactamase-IN-10
0 ImagesCat. No.: HY-178975β-Lactamase-IN-10 (Compound CB1) is a dual-metal β-lactamase (MLB) and serine β-lactamase (SLB) inhibitor. β-Lactamase-IN-10 exhibits antibacterial (antibacterial) activity against various drug-resistant bacteria. β-Lactamase-IN-10 can be used in the research of Gram-negative superbug infections.
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Metallo-β-lactamase-IN-9
0 ImagesCat. No.: HY-152105CAS No.: 1802363-75-2Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC50s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively.
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NDM-1-IN-12
0 ImagesCat. No.: HY-179709NDM-1-IN-12 (Compound 10c) is an inhibitor of NDM-1 metallo-β-lactamase, with an IC50 value of 9 nM. NDM-1-IN-12 effectively reverses bacterial resistance to β-lactam antibiotics and shows an additive effect when used in combination with antibiotics and SBL inhibitors. NDM-1-IN-12 can be used in the research of anti-multi-drug resistant bacteria.
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Nacubactam (Standard)
0 ImagesCat. No.: HY-109008RCAS No.: 1452458-86-4Synonyms: OP0595 free acid (Standard)Nacubactam (Standard) is the analytical standard of Nacubactam (HY-109008). This product is intended for research and analytical applications. Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and C β-lactamases. Nacubactam acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs. Nacubactam potentiates the antimicrobial activities of Piperacillin (HY-B1923), Cefepime (HY-B0692), and Meropenem (HY-13678) against CTX-M-15-positive Escherichia coli and KPC-positive Klebsiella pneumoniae.
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Cefditoren pivoxil-d3
0 ImagesCat. No.: HY-17452ASSynonyms: Cefditoren pivoxyl-d3; Cefditoren pivaloyloxymethyl ester-d3; ME 1207-d3Cefditoren Pivoxil-d3 (Cefditoren pivoxyl-d3) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
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Cefotaxime sodium (Standard)
0 ImagesCat. No.: HY-A0088RCAS No.: 64485-93-4Synonyms: Cefotaxim sodium (Standard); HR-756 sodium (Standard)Cefotaxime (sodium) (Standard) is the analytical standard of Cefotaxime (sodium). This product is intended for research and analytical applications. Cefotaxime (Cefotaxim) sodium, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.
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Fmoc-FFC
0 ImagesCat. No.: HY-189634Fmoc-FFC is a competitive MBL (NDM-1, VIM-2, and IMP-1) inhibitor with Ki values of 2.3, 6.0, and 7.1 μM, respectively. Fmoc-FFC alone has no antibacterial activity, but acts synergistically with Meropenem (HY-13678) to restore antibacterial activity against MBL/NDM-1-producing E. coli. Fmoc-FFC supports cell-cell adhesion and can serve as a scaffold for cell culture growth. Fmoc-FFC can be used in research on systemic infections caused by NDM-1-producing E. coli.
