Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Controls
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Drug Derivative Related Products (4062)
Related Products (4062)
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1,3,5,7-Tetrahydroxy-8-isoprenylxanthone
0 ImagesCat. No.: HY-N17015CAS No.: 444004-76-61,3,5,7-Tetrahydroxy-8-isoprenylxanthone is a natural xanthone.
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Stacofylline
0 ImagesSynonyms: S 9977 free base; S 9977-2 free baseStacofylline (S 9977 free base; S 9977-2 free base), a Xanthine (HY-W017389) derivative, is a potent AChE inhibitor with an IC50 of 5-50 nM. Stacofylline shows anti-amnesic and promnesic activities.
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Lyciumin C
0 ImagesCat. No.: HY-N17415CAS No.: 150394-23-3Lyciumin C is a monocyclic octapeptide containing a novel C-N linkage between tryptophan N1 and glycine Cα, and can be found in the root bark of Lycium chinense MILL.
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Lyso-Monosialoganglioside GM3
0 ImagesCat. No.: HY-171443CAS No.: 94458-63-6Synonyms: Lyso-GM3Lyso-Monosialoganglioside GM3 (Lyso-GM3) is an analogue of Ganglioside GM3 (HY-114456) with antitumor activities. Lyso-Monosialoganglioside inhibits EGF-induced increases in EGFR kinase activity in A431 epithelial cancer cells.
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BW-AQ-113
0 ImagesCat. No.: HY-177208CAS No.: 1537900-10-9BW-AQ-113 is an Anthraquinone (HY-N0354) derivative. BW-AQ-113 can specifically degrade MDM2 and activate the p53 pathway. BW-AQ-113 can induce apoptosis by downregulating anti-apoptotic gene Bcl-2 and regulating pro-apoptotic gene Bax and CASP3. BW-AQ-113 can be used for research of p53 wild-type hematological malignancies.
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Cucurbitaxanthin A
0 ImagesCat. No.: HY-W782495CAS No.: 103955-77-7Synonyms: CapsoluteinCucurbitaxanthin A (Capsolutein) is a peculiar carotenoid containing an 3,6-oxabicycloheptane end group. Cucurbitaxanthin A is a carotenoid pigment.
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1-Hydroxy-3,4,5-trimethoxyxanthone
0 ImagesCat. No.: HY-N7908CAS No.: 23251-63-01-Hydroxy-3,4,5-trimethoxyxanthone is a natural product that can be found in Rubia cordifolia?L..
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Antiproliferative agent-69
0 ImagesCat. No.: HY-N15577CAS No.: 1859979-00-2Antiproliferative agent-69 (Compound 1) is a prenylated kaempferol derivative found in the fresh bud’s fur of Platanus acerifolia. Antiproliferative agent-69 shows significant antiproliferative effects against human breast cancer cells (MCF-7) and human hepatocellular carcinoma cells (Hep-G2) with IC50 values of 38.2 μM and 39.5 μM, respectively. Antiproliferative agent-69 is promising for research of breast cancer and liver cancer.
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Ro 31-2201
0 ImagesCat. No.: HY-123180CAS No.: 88851-65-4Ro 31-2201 is an active compound.
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Minisecolide D
0 ImagesCat. No.: HY-N13762CAS No.: 1967030-78-9Minisecolide D is a natural steroid.
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7-epi-Teucrenone
0 ImagesCat. No.: HY-N16678ACAS No.: 165898-48-67-epi-Teucrenone is a natural sesquiterpene.
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Dicyclonon
0 ImagesCat. No.: HY-121274CAS No.: 79260-71-2Synonyms: BAS-145138; LAB 145138; LAB 145138HDicyclonon is an active compound.
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Baccatin X
0 ImagesCat. No.: HY-N16920CAS No.: 1623069-76-0Baccatin X is a natural diterpene.
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(+)-Fargesin
0 ImagesCat. No.: HY-N9700CAS No.: 68296-27-5(+)-Fargesin is a natural lignan.
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RU 23686 free base
0 ImagesCat. No.: HY-W052248CAS No.: 52157-82-1RU 23686 free base is a piperidinylindole derivative. RU 23686 free base can be used to investigate the extent to which different neurotransmitters by the interaction with pharmacological agents.
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Neotame (Standard)
0 ImagesCat. No.: HY-W011053RCAS No.: 165450-17-9Neotame (Standard) is the analytical standard of Neotame (HY-W011053). This product is intended for research and analytical applications. Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar. Neotame causes intestinal epithelial cell death at high concentrations. Neotame induces Apoptosis of Caco-2 cells.
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SM-21
0 ImagesCat. No.: HY-14223CAS No.: 155058-71-2SM-21 is a derivative of R-(+)-hyoscyamine with potent antinociceptive and cognitive enhancing activities. SM-21 works by affecting the release of acetylcholine.
