Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Related Products (4062)
Related Products (4062)
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4-APDB hydrochloride
0 ImagesCat. No.: HY-129864ACAS No.: 1203342-42-04-APDB hydrochloride is a benzofuran.
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Tinazoline
0 ImagesCat. No.: HY-W720736CAS No.: 62882-99-9Tinazoline, imidazole derivative, is a vasoconstrictor. Tinazoline can as nasal decongestant for the research of common cold.
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N-Desmethyl Regorafenib-d3
0 ImagesCat. No.: HY-120422SN-Desmethyl Regorafenib-d3 is the deuterated-labeled N-Desmethyl Regorafenib (HY-120422). N-Desmethyl Regorafenib is a demethylated metabolite of Regorafenib (HY-10331), formed by N-demethylation, and is found in feces and occasionally in plasma as a trace component. N-Desmethyl Regorafenib is a substrate for amide hydrolysis.
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4-Hydroxythonningianin B
0 ImagesCat. No.: HY-N17162CAS No.: 2329726-95-4Synonyms: 4'-O-(4,6-O-Hexahydroxydiphenoyl-β-D-glucopyranosyl)phloretin4-Hydroxythonningianin B (4'-O-(4,6-O-Hexahydroxydiphenoyl-β-D-glucopyranosyl)phloretin) is a natural chalcone.
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Epoxyligustilide
0 ImagesCat. No.: HY-N21613CAS No.: 106533-40-8Epoxyligustilide is a phthalide derivative found in the rhizomes of Ligusticum wallichii. Epoxyligustilide is the non-Z configuration of (Z)-6,7-Epoxyligustilide (HY-N17975).
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Tetrantoin
0 ImagesCat. No.: HY-122400CAS No.: 52094-70-9Synonyms: SpirodonTetrantoin (Spirodon) is a spirocyclic hydantoin and anticonvulsant with an approximate ED50 of 54 mg/kg.Tetrantoin inhibits and prevents convulsions induced by maximum electric shock test.Tetrantoin can be used for the research of epilepsy.
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1,2,3,6,7-Pentamethoxyxanthone
0 ImagesCat. No.: HY-N8772CAS No.: 64756-86-11,2,3,6,7-Pentamethoxyxanthone is a natural xanthone.
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Bromobutide
0 ImagesCat. No.: HY-116802CAS No.: 74712-19-9Bromobutide is an active ingredient in herbicides that kill weeds. Bromobutide has the highest control effect on Scirpus juncoides and Monochloa vaginalis, but has no inhibitory effect on weed seed germination. The main metabolites of bromobutide in rats are alcohol or phenol glucuronides, which enter the enterohepatic circulation.
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MS2126
0 ImagesCat. No.: HY-124395CAS No.: 16078-42-5MS2126 is an active compound.
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Neuroprotective agent 17
0 ImagesCat. No.: HY-186092CAS No.: 2243170-47-8Neuroprotective agent 17 (Derivative 15) is a phenylpiperazine derivative. Neuroprotective agent 17 can be used for the research of neurological diseases such as Parkinson's disease and Alzheimer's disease.
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Averionol
0 ImagesCat. No.: HY-W876243CAS No.: 1244-78-6Averionol (Compound 26) is a flavonoid compound. Averionol has no significant inhibitory activity against HIV integrase. Averionol can be used in the development of anti-HIV agents.
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Lotrifen
0 ImagesCat. No.: HY-122349CAS No.: 66535-86-2Synonyms: L-12717Lotrifen is a non-hormonal compound with abortifacient effects. Lotrifen is most effective when used on the 20th day of pregnancy in beagle and mongrel dogs.
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(2S)-Pinocembrin 7-O-[cinnamoyl(1→5)-β-D-apiosyl(1→2)]-β-D-glucoside
![(2S)-Pinocembrin 7-O-[cinnamoyl(1→5)-β-D-apiosyl(1→2)]-β-D-glucoside](https://file.medchemexpress.com/product_pic/hy-n16923.gif "Click to View (2S)-Pinocembrin 7-O-[cinnamoyl(1→5)-β-D-apiosyl(1→2)]-β-D-glucoside Product Detail")
0 ImagesCat. No.: HY-N16923CAS No.: 773899-29-9(2S)-Pinocembrin 7-O-[cinnamoyl(1→5)-β-D-apiosyl(1→2)]-β-D-glucoside is a natural flavonoid.
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Rapamycin-butyl ester
0 ImagesCat. No.: HY-181873Synonyms: Sirolimus-butyl esterRapamycin-butyl ester (Sirolimus-butyl ester) (Compound 9) is a derivative of Rapamycin (HY-10219). Rapamycin-butyl ester exhibits antiproliferative effects against liver cancer cells and renal cancer cells. Rapamycin-butyl ester can be used in research related to liver cancer and renal cancer.
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Ustusol C
0 ImagesCat. No.: HY-N9100CAS No.: 1188398-13-1Ustusol C is a natural sesquiterpene.
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Aspergillumarin B
0 ImagesCat. No.: HY-N16401CAS No.: 1392495-07-6Aspergillumarin B (Compound 2) is a derivative of dihydroisocoumarin. Aspergillumarin B can be isolated from the endophytic fungus Aspergillus sp.. Aspergillumarin B has a weak antibacterial activity against Staphylococcus aureus and Bacillus subtilis.
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6-O-Acetylacteoside
0 ImagesCat. No.: HY-N18355CAS No.: 441769-43-3Synonyms: 6-O-Acetylact6-O-Acetylacteoside (6-O-Acetylact) is a Acteoside (HY-N0021) analog. 6-O-Acetylacteoside can scavenge radical.
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Anethole trithione derivative-1
0 ImagesCat. No.: HY-189057Anethole trithione derivative-1 is a derivative of Anethole trithione (HY-B1223), and also a regulator of sulfide:quinone oxidoreductase (SQR) and uncoupling protein 2 (UCP2), with mitochondrial uncoupling-inducing activity and neuroprotective activity. Anethole trithione derivative-1 mediates mitochondrial uncoupling via SQR-dependent reverse electron transport of complex I, ROS-dependent UCP2 activation, and reduction of mitochondrial membrane potential. Anethole trithione derivative-1 reduces brain damage and improves function in mouse models of ischemic and hemorrhagic stroke. Anethole trithione derivative-1 can be used in stroke research.
