iGluR
Ionotropic glutamate receptors
iGluR (ionotropic glutamate receptor) is a ligand-gated ion channel that is activated by the neurotransmitter glutamate. iGluR are integral membrane proteins compose of four large subunits that form a central ion channel pore. Sequence similarity among all known glutamate receptor subunits, including the AMPA, kainate, NMDA, and δ receptors.
AMPA receptors are the main charge carriers during basal transmission, permitting influx of sodium ions to depolarise the postsynaptic membrane. NMDA receptors are blocked by magnesium ions and therefore only permit ion flux following prior depolarisation. This enables them to act as coincidence detectors for synaptic plasticity. Calcium influx through NMDA receptors leads to persistent modifications in the strength of synaptic transmission.
iGluR Isoform Specific Products
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iGluR Inhibitors
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iGluR Agonists
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iGluR Antagonists
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iGluR Activators
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iGluR Modulators
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iGluR MDM2 Inhibitor
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iGluR Controls
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iGluR Ligands
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iGluR Related Products (830)
Related Products (830)
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Antibodies (11)
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iGluR Isoform Comparison
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NMDA receptor modulator 2
0 ImagesCat. No.: HY-143390CAS No.: 2758255-05-7NMDA receptor modulator 2 (Compound 1) is a potent NMDA receptor modulator. NMDA receptor modulator 2 can be used for neurological disorder research.
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Risevistinel
0 ImagesCat. No.: HY-156634CAS No.: 2591344-26-0Synonyms: NYX-783Risevistinel (NYX-783) is a positive allosteric modulator of N-methyl-D-aspartate (NMDA) receptor. Nevadistinel can be used to inhibit cognitive impairment associated with neurodegenerative diseases, such as mild cognitive impairment, mild Alzheimer's disease, Parkinson's disease, Lewy body disease.
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CX516-d10
0 ImagesCat. No.: HY-10933SCAS No.: 1286653-21-1Synonyms: BDP 12-d10CX516-d10 is the deuterium labeled CX516. CX516 (BDP 12) is an ampakine and acts as an AMPA receptor positive allosteric modulator for the research of Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI).
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UBP710
0 ImagesCat. No.: HY-124264CAS No.: 1333111-40-2UBP710 is a selective NMDA receptor modulator. UBP710 displays greater activity in potentiating GluN2B-containing receptors than those containing GluN2A.
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EMD 21657
0 ImagesCat. No.: HY-114987CAS No.: 61711-37-3EMD 21657 is a derivative of Piracetam (HY-B0585). EMD 21657 inhibits LOT compound action potential, and enhances the local anesthetic effect of Hexanol (HY-W032022). EMD 21657 exhibits hemolytic effect, and can be used in research about alcoholic encephalopathy syndrome.
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NMDA receptor modulator 5
0 ImagesCat. No.: HY-143396CAS No.: 2758256-97-0NMDA receptor modulator 5 (Compound 195) is a potent NMDA receptor modulator. NMDA receptor modulator 5 can be used for neurological disorder research.
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CNS0042
0 ImagesCat. No.: HY-183948CAS No.: 2419233-87-5CNS0042 is an allosteric modulator of NMDA receptor. CNS0042 can be used for the research of NMDA receptor-mediated neurological or psychiatric disease.
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LSP-GR3
0 ImagesCat. No.: HY-148828CAS No.: 1235945-37-5LSP-GR3 is a novel chemically-modified RNA oligonucleotides, called splice modulating oligomers (SMOs), which potently and specifically modulate GluR alternative splicing to GluR3-flip expression throughout the CNS.
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Dual Nav/NMDAR-IN-1
0 ImagesCat. No.: HY-184718Dual Nav/NMDAR-IN-1 (compound 11a) is a dual-target modulator of Nav and NMDAR. Dual Nav/NMDAR-IN-1 increases the thermal stability of Nav and NMDAR and slows their proteolytic degradation, indicating that it binds to both Nav and NMDAR simultaneously. Dual Nav/NMDAR-IN-1 exhibits anticonvulsant activity in a pentylenetetrazole-induced mouse model of seizures and can be used in epilepsy-related research.
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PF-4778574
0 ImagesCat. No.: HY-14451CAS No.: 1219633-99-4PF-4778574 is a positive allosteric modulation of AMPA receptor with EC50 of 45 to 919 nM in differenct cells.
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BRD3290
0 ImagesCat. No.: HY-187700BRD3290 is a GluA3-preferring AMPA receptor positive allosteric modulator with brain exposure in Mus musculus (mice) following peripheral administration. BRD3290 preferentially potentiates GluA3-containing AMPA receptors over GluA1/2-containing AMPA receptors. BRD3290 increases cerebellar cGMP levels in Mus musculus (mice). BRD3290 does not induce convulsions, alter motor function, or improve novel object recognition task performance in Mus musculus (mice) at tested doses. BRD3290 can be used for the research of schizophrenia.
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Nooglutil
0 ImagesCat. No.: HY-114576CAS No.: 112193-35-8Synonyms: Nooglutyl; ONK-10Nooglutil (Nooglutyl; ONK-10) is a positive modulator of AMPA-type glutamate receptors (AMPARs). Nooglutil also regulates dopamine D2 receptor function to exert anxiolytic effects. Nooglutil is promising for research of neurodegenerative disorders (e.g., Alzheimer’s disease).
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AMPA receptor modulator-5
0 ImagesCat. No.: HY-154798CAS No.: 2034182-22-2AMPA receptor modulator-5 (Example 217) is an AMPA receptor modulator. AMPA receptor modulator-5 can be used for research of neurological disease.
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AMPA receptor modulator-7
0 ImagesCat. No.: HY-161090AMPA receptor modulator-7 (compound 36) is a modulator of AMPA receptor. AMPA receptor modulator-7 has oral activity and can penetrate the blood-brain barrier.
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Piracetam (Standard)
0 ImagesPiracetam (Standard) is the analytical standard of Piracetam. This product is intended for research and analytical applications. Piracetam (UCB-6215) is a cyclic derivative of the neurotransmitter gamma-aminobutyric acid (GABA), used in treatment of a wide range of cognitive disorders.
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Nevadistinel
0 ImagesCat. No.: HY-156626CAS No.: 2181816-92-0Synonyms: NYX-458; NYX-3054Nevadistinel (NYX-458; NYX-3054) is a positive allosteric modulator of N-methyl-D-aspartate (NMDA) receptor. Nevadistinel can be used to inhibit cognitive impairment associated with neurodegenerative diseases, such as mild cognitive impairment, mild Alzheimer's disease, Parkinson's disease, Lewy body disease.
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NMDA receptor potentiator-1
0 ImagesCat. No.: HY-147352CAS No.: 486427-18-3NMDA receptor potentiator-1 (Compound 1368) is a subunit selective NMDA receptor potentiator with IC50s of 4 μM and 5 μM against NR2C and NR2D expression, respectively.
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NMDA receptor modulator 4
0 ImagesCat. No.: HY-143393CAS No.: 2758256-71-0NMDA receptor modulator 4 (Compound 169) is a potent NMDA receptor modulator. NMDA receptor modulator 4 can be used for neurological disorder research.
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NMDA receptor modulator 3
0 ImagesCat. No.: HY-143391CAS No.: 2758256-02-7NMDA receptor modulator 3 (Compound 99) is a potent NMDA receptor modulator. NMDA receptor modulator 3 can be used for neurological disorder research.
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NMDA receptor modulator 6
0 ImagesCat. No.: HY-143397CAS No.: 2758256-85-6NMDA receptor modulator 6 (Compound 183) is a potent NMDA receptor modulator. NMDA receptor modulator 6 can be used for neurological disorder research.
