2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PANK
  5. PANK Isoform

PANK

 

PANK Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-139729
    HOPan
    		Substrate 99.83%
    HOPan is a PanK substrate and Pantothenate (HY-B0430) analog. HOPan inhibits CoA levels.
  • HY-124634
    PZ-2891
    		Modulator 99.68%
    PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.
  • HY-144734
    Pantothenate kinase-IN-1
    		Inhibitor 98.20%
    Pantothenate kinase-IN-1 is a PANK3 inhibitor with an IC50 of 0.51 μM. Pantothenate kinase-IN-1 acts as a pantothenate-competitive inhibitor, which occupies the pantothenate-binding site of PANK3 and binds to both protomers in the PANK3 dimer. Pantothenate kinase-IN-1 exhibits metabolic stability in mouse and rat plasma. Pantothenate kinase-IN-1 can be used in the research of pantothenate kinase-associated neurodegenerative diseases and metabolic diseases.
  • HY-164909
    PZ-3022
    PZ-3022 is an orally active and allosteric PanK activator that counteracts C3-CoA inhibition. PZ-3022 increases hepatic CoASH and C2-CoA and decreases C3-CoA in the propionic acidemia mouse model. PZ-3022 can be used for research of mitochondrial defect in propionic acidemia.