Transmembrane Glycoprotein Inhibitor

Anti-Rat CD86 Antibody (OX-48) recognizes CD86, thereby blocking the binding of CD86 to CD28, and thus inhibiting T cell proliferation. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).

Anti-Mouse CD318 Antibody (9a2) reacts with the mouse that selectively recognized native CD318 protein on both human and mouse cell surfaces in flow cytometry assays.

DNP002 is a humanized IgG1 monoclonal antibody targeting tumor-associated CEACAM6. DNP002 binds to CEACAM1, CEACAM5 and CEACAM6, and exhibits antibody-dependent cellular cytotoxicity against tumor cells overexpressing these targets. DNP002 binds to CEACAM6 on the surface of tumor-associated neutrophils (including MDSCs) to reverse the immunosuppressive effect in the tumor microenvironment. DNP002 shows anti-tumor activity in advanced solid tumors. DNP002 can be used for the research of advanced solid tumors. The recommended isotype control is human IgG1 kappa (HY-P99001).

CD36 Peptide P (139-155), Cys conjugated is a Cys labelled CD36 Peptide, and can inhibit the immunoadsorption of CD36 by OKM5.

Anti-Mouse TIM-1/CD365 Antibody (RMT1-10) reacts with mouse T cell immunoglobulin and mucin domain 1 (TIM-1). Anti-Mouse TIM-1/CD365 Antibody (RMT1-10) is effective in promoting allograft survival through blocking TIM-1. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).

Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse ICOSL/CD275. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) is a chimeric antibody of the original HK5.3 antibody (HY-P990123). Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) contains the D265A mutation region. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) can neutralize ICOSL. Anti-Mouse ICOSL/CD275 (D265A) Antibody (HK5.3) can be used for researches of inflammation and infection.

PP6373 Antibody is a human IgG1 kappa monoclonal CD24 antibody. The recommended isotype control is HY-P99001.

Anti-Mouse CD80 Antibody (16-10A1) reacts with mouse CD80 that can block CD80 in vivo. Recommend Isotype Controls: Polyclonal Armenian hamster IgG, Isotype Control (HY-P990305).

BDC2.5 mimotope 1040-31 TFA, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg⁺ T cells.

Zolimomab is an anti-human monoclonal antibody targeting-CD5. Zolimomab binds to the CD5 antigen found on mature T-cells. Zolimomab can be used for the research of graft-versus-host disease (GVHD).

ST2485 is a monoclonal antitenascin antibody. ST2485 shows additivity in tenascin C binding in vitro as well as in a xenograft model. ST2485 binds human tenascin at an epitope partially shared with BC2. ST2485 cross-reacts with murine tenascin. ST2485 can be studied in antitumor research.

Anti-Mouse CD155 Antibody (4.24) reacts with the mouse CD155. CD155 is a member of a subfamily of immunoglobulin-like adhesion receptors. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).

MTRX1011A is a humanized IgG1 monoclonal antibody inhibitor targeting CD4. MTRX1011A can be used for rheumatoid arthritis (RA) research.

Anti-Mouse CD8 Antibody (HB-129) is a mouse-derived IgG2a κ type antibody inhibitor, targeting to mouse CD8. Anti-Mouse CD8 Antibody (HB-129) can deplete CD8⁺ T cells. Anti-Mouse CD8 Antibody (HB-129) can be used for the researches of cancer, inflammation, immunology and metabolic disease, such as P815 tumor, experimental autoimmune thyroiditis (EAT) and graft versus host disease (GVHD).

Anti-CD318/CDCP1 Antibody (25A11) is an anti-CDCP1 antibody. Anti-CD318/CDCP1 Antibody (25A11) drives the internalization of antibody-CDCP1 complexes, inhibits cancer cell migration and invasion, and blocks downstream migration/invasion signaling pathways. When conjugated with saponin, Anti-CD318/CDCP1 Antibody (25A11) mediates the killing of prostate cancer cells. When conjugated with saponin, this antibody acts as an immunotoxin to inhibit the growth and metastasis of primary prostate tumors in mouse xenograft models. Anti-CD318/CDCP1 Antibody (25A11) is applicable to prostate cancer-related research.

MAI1738 is a human monoclonal antibody targeting PODXL. MAI1738 can be used for cancer-related research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

Anti-CEACAM7 Antibody (P3-7B) is a kind of mouse IgG1 κ chimeric antibody, targeting to human CEACAM7. Anti-CEACAM7 Antibody (P3-7B) reacts with human carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7). Anti-CEACAM7 Antibody (P3-7B) can be used for detecting CEACAM7 in cancer.

HA-CD44 interaction inhibitor 3 (compound 5d) is a Hyaluronic acid (HY-B0633A) (HA)-CD44 interaction inhibitor with antiproliferative activities. HA-CD44 interaction inhibitor 3 inhibits MDA-MB-231 (CD44++) cells and MCF-7 cells (CD44--) with EC₅₀s of 4.24 μM and 14.74 μM, respectively. HA-CD44 interaction inhibitor 3 shows the potential for cancer research.

MEN1112 (OBT357NF; OBT357) is a defucosylated humanized monoclonal antibody targeting Bst1/CD157, with an EC₅₀ of 0.4 nM. MEN1112 binds to Bst1/CD157 on acute myeloid leukemia cells, triggers slow antigen internalization, induces antibody-dependent cell-mediated cytotoxicity, and mediates the lysis of acute myeloid leukemia cells and blasts. MEN1112 is applicable for research related to acute myeloid leukemia.

Anti-Mouse CD4 Antibody (YTS 177) reacts with the mouse CD4. Anti-Mouse CD4 Antibody (YTS 177) shows non-depleting but binding does induce rapid internalization of CD4 on both CD4⁺ Foxp3- T cells and Foxp3⁺ regulatory T cells. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).