Virus Protease
Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.
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Virus Protease Related Products (404)
Related Products (404)
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Antibodies (1)
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Mpro ligand 2
0 ImagesCat. No.: HY-161791CAS No.: 2816967-14-1
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SARS-CoV-2 Mpro-IN-4
0 ImagesCat. No.: HY-151900SARS-CoV-2 Mpro-IN-4 is a dual Inhibitor of Main Protease (MPro) and Cathepsin L (CatL), with IC50s of 900 nM and 60 nM respectively. SARS-CoV-2 Mpro-IN-4 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-4 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC50 value of 8.2 nM.
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HCVcc-IN-1
0 ImagesCat. No.: HY-151581CAS No.: 2977251-08-2HCVcc-IN-1 is a benzothiazole-2-thiophene S-glycoside derivative with low toxic and antiviral activity.
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4-Methylanisole-d3
0 ImagesCat. No.: HY-W012835S1CAS No.: 14202-49-4Synonyms: 4-Methoxytoluene-d34-Methylanisole-d3 is the deuterium labeled 4-Methylanisole. 4-Methylanisole (4-Methoxytoluene) is food flavoring agent and can be naturally found in Ylang Ylang fragrance oil.
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TMP1
0 ImagesCat. No.: HY-175344TMP1 is an orally active bispecific inhibitor of M pro (IC50 = 312.5 nM)/TMPRSS2 (IC50 = 1.28 μM, KD = 10.10 μM). TMP1 exhibits broad protection against different SARS-CoV-2 variants in vitro. TMP1 cross-protects against highly pathogenic coronaviruses (SARS-CoV-1, SARS-CoV-2, and MERS-CoV) in vivo and effectively blocks the transmission of SARS-CoV-2. TMP1 can inhibit infection by SARS-CoV-2 escape mutants that are resistant to Nivolumab (HY-P9903). TMP1 can be used in coronavirus research.
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FGA145
0 ImagesCat. No.: HY-161244FGA145 is a dual, selective inhibitor for Mpro and human Cathepsin L, with Kis of 3.71 μM, 9.82 μM and 53 nM, for Mal-Mpro, pET21-Mpro and Cathepsin L, respectively. FGA145 reveals a multitarget effects in the antiviral activity.
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JMX0254
0 ImagesCat. No.: HY-149467CAS No.: 2375960-04-4JMX0254 is an orally active and potent inhibitor of the dengue virus NS4B protein. JMX0254’s EC50 for DENV-1, DENV-2, and DENV-3 are 0.78 µM, 0.16 µM, and 0.035 µM, respectively. JMX0254 can be used for research on viral infections.
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L-Lysine-13C6,15N2,d9 dihydrochloride
0 ImagesL-Lysine-13C6,15N2,d9 (dihydrochloride) is the deuterium, 13C-, and 15-labeled L-Lysine hydrochloride. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
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Phenytoin-15N2,13C
0 ImagesPhenytoin-15N2,13C is the 13C and 15N labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
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Dutacatib
0 ImagesCat. No.: HY-100701CAS No.: 501000-36-8Dutacatib is inhibitor for SARS-CoV-2 3CLpro and cathepsin K, which exhibits antiviral activity and ameliorates the cancer-induced bone diseases.
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SARS-CoV-2-IN-58
0 ImagesCat. No.: HY-156008CAS No.: 3052692-38-0SARS-CoV-2-IN-58 (Compound 21H) is an antiviral agent against SARS-CoV-2 (EC50: 18 μM). SARS-CoV-2-IN-58 inhibits SARS-CoV-2 Mpro with an IC50 of 0.35 μM.
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CYP2C9/CYP2C19-IN-1
0 ImagesCat. No.: HY-151251CAS No.: 3010895-55-0CYP2C9/CYP2C19-IN-1 (compound 22d) is a potent CYP2C9/CYP2C19 inhibitor, possessing no hepatotoxicity and ames toxicity. CYP2C9/CYP2C19-IN-1 can be used in study of anti-ZIKV.
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ZIKV-IN-4
0 ImagesCat. No.: HY-151447CAS No.: 3033697-91-2ZIKV-IN-4 (compound 5b) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=3.49 μM). ZIKV-IN-4 effectively inhibits the activity of ZIKV NS5 MTase.
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L-Lysine hydrochloride (Standard)
0 ImagesL-Lysine hydrochloride (Standard) is the analytical standard of L-Lysine hydrochloride. This product is intended for research and analytical applications. L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, increasing calcium absorption, reducing diabetes-related illnesses and improving gut health.
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SARS-CoV-2-IN-107
0 ImagesCat. No.: HY-169974CAS No.: 3087307-24-9SARS-CoV-2-IN-107 (Compound A7) is the inhibitor for SARS-CoV-2 3CLpro with an IC50 of 261.3 nM. SARS-CoV-2-IN-107 inhibits the SARS-CoV-2 replication with an EC50 of 11.7 μM. SARS-CoV-2-IN-107 exhibits anti-inflammatory activity with a NO inhibition rate of 68.6% in LPS (HY-D1056)-stimulated RAW264.7 macrophages.
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DEMAMP
0 ImagesCat. No.: HY-181176DEMAMP is an antioxidant. DEMAMP exhibits scavenging effects on DPPH and H2O2 free radicals, with IC50 values of 0.60 and 0.48 mg/mL, respectively. Molecular docking simulations show that DEMAMP potently inhibits NADPH oxidase and the Mpro and RdRp proteins of SARS-CoV-2, and ADMET analysis confirms that it has favorable oral bioavailability. DEMAMP can be used in studies related to COVID-19.
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β-Herpesvirus protease-IN-1
0 ImagesCat. No.: HY-155379CAS No.: 3054032-05-9β-Herpesvirus protease-IN-1 (compound 19) is a β-herpesvirus protease inhibitor with IC50s of 2.5 μM and 0.33 μM for HCMVPro and HHV6Pro, respectively.
