1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. Vinconate

Vinconate (Synonyms: Chanodesethylapovinc​amine)

Cat. No.: HY-U00316
Handling Instructions

Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.

For research use only. We do not sell to patients.

Vinconate Chemical Structure

Vinconate Chemical Structure

CAS No. : 70704-03-9

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Description

Vinconate is an indolonaphthyridine derivative and can stimulate the muscariic acetylcholine receptor.

IC50 & Target

muscariic acetylcholine receptor[1]

In Vivo

Treatment with Vinconate (50 to 200 mg/kg p.o.) significantly increases dopamine concentrations in dialysate. Daily treatment with Vinconate (25 mg/kg) for 7 days also significantly increases dopamine and serotonin concentrations in dialysate[1]. Chronic treatment with Vinconate at a 10 mg/kg significantly ameliorats the reduction in [3H]QNB binding in the nucleus accumbens and cerebellum. Furthermore, this Vinconate treatment significantly enhances [3H]QNB binding in the frontal cortex and hippocampus compare with the vehicle-treated aged animals. Also, chronic treatment with Vinconate at the higher dose significantly elevates [3H]QNB binding in the hippocampal CA3 sector and dentate gyrus compare with the vehicle-treated aged animals. Chronic treatment with Vinconate at a dose of 10 mg/kg shows a significant reduction in [3H]HC binding only in the hippocampal CA1 sector compare with the vehicle-treated aged rats[2].

Molecular Weight

296.36

Formula

C₁₈H₂₀N₂O₂

CAS No.

70704-03-9

SMILES

O=C(C1=CCC2N(CC)CCC3=C2N1C4=C3C=CC=C4)OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[2]

344 male rats, 6 months (adult) and 24 months (aged) of age, are allowed food and water ad lib throughout the experiments. Rats are divided into four groups; (1) 6-month-old; (2) vehicle (distilled water) is administered intraperitoneally (i.p.) once a day for 4 weeks before decapitation; (3) Vinconate at a dose of 10 mg/kg is administered i.p. once a day for 4 weeks before decapitation; (4) Vinconate at a dose of 30 mg/kg is administered i.p. once a day for 4 weeks before decapitation. Rats in groups (2) to (4) are 24 months old. Each group contains 6 to 7 rats. In addition, there are no significant differences among the three aged animal groups in body weight after drug or vehicle treatment[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

VinconateChanodesethylapovinc​aminemAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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