2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. Acoltremon

Acoltremon  (Synonyms: WS-12; AR-15512; AVX-012)

Cat. No.: HY-108449 Purity: 99.90%
COA Handling Instructions

Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research.

For research use only. We do not sell to patients.

Acoltremon Chemical Structure

Acoltremon Chemical Structure

CAS No. : 68489-09-8

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10 mM * 1 mL in DMSO USD 109 In-stock
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Based on 1 publication(s) in Google Scholar

Acoltremon Related Antibodies

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TRPC TRPM TRPV TRPA TRPML

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Description

Acoltremon (WS-12; AR-15512) is a potent and selective TRPM8 agonist, the menthol derivative, as a cooling agent. Acoltremon shows analgesic effect, and can be used in chronic neuropathic pain research[1][2].

IC50 & Target[1]

TRPM8

 

In Vitro

Acoltremon (10 μM) shows TRPM8 agonism in tests on heterologously expressed TRP ion channels[1].
Acoltremon (1 or 10 μM; 0-250 s) shows highly potent and specific TRPM8 channel agonist in DRG neurons[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Acoltremon Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK293T cells
Concentration: 10 μM
Incubation Time:
Result: Activated mouse TRPM8 (mTRPM8), but neither activated nor inhibited mTRPA1.

Cell Viability Assay[1]

Cell Line: Cultured mouse DRG neurons
Concentration: 1 or 10 μM
Incubation Time: 0-250 s
Result: Showed approximately 10% to 14% of cultured wild-type neurons responsive to WS-12.
In Vivo

Acoltremon (intraperitoneal injection; 10 mg/kg; once) shows analgesic effect by selective TRPM8 activation in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Trpm8–/– mice and mice injected with Capsaicin[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg; once
Result: Produced an obvious analgesic effect, and this effect abolished in Trpm8–/– mice.
Showed no change falling latencies in mice in the rotarod test.
Reduced Capsaicin-induced nocifensive behavior.
Clinical Trial
Molecular Weight

289.41

Appearance

Solid

Formula

C18H27NO2
CAS No.
SMILES

O=C([C@H]1[C@H](C(C)C)CC[C@@H](C)C1)NC2=CC=C(OC)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (69.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4553 mL 17.2765 mL 34.5531 mL
5 mM 0.6911 mL 3.4553 mL 6.9106 mL
10 mM 0.3455 mL 1.7277 mL 3.4553 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (6.91 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Acoltremon Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

Acoltremon68489-09-8WS-12 AR-15512 AVX-012WS12WS 12AR15512AR 15512AR-15512AVX012AVX 012AVX-012TRP ChannelTransient receptor potential channelsanalgesic effectchronic neuropathic painHEK293Tcultured mouse DRG neuronsInhibitorinhibitorinhibit

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