1. GPCR/G Protein
  2. GNRH Receptor
  3. Abarelix Acetate

Abarelix Acetate (Synonyms: PPI 149 Acetate; R 3827 Acetate)

Cat. No.: HY-13534A Purity: 99.62%
Handling Instructions

Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research.

For research use only. We do not sell to patients.

Abarelix Acetate Chemical Structure

Abarelix Acetate Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 487 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 300 In-stock
Estimated Time of Arrival: December 31
25 mg USD 660 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1140 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Abarelix Acetate (PPI 149 Acetate; R 3827 Acetate) is a potent gonadotrophin-releasing hormone (GnRH) antagonist, used for prostate cancer research[1].

IC50 & Target

GnRH[1]

Clinical Trial
Molecular Weight

1476.12

Formula

C₇₄H₉₉ClN₁₄O₁₆

SMILES

CC(O)=O.C[[email protected]](C(N)=O)NC([[email protected]]1N(C([[email protected]](CCCCNC(C)C)NC([[email protected]](CC(C)C)NC([[email protected]@H](CC(N)=O)NC([[email protected]](CC2=CC=C(C=C2)O)N(C([[email protected]](CO)NC([[email protected]@H](CC3=CC=CN=C3)NC([[email protected]@H](CC4=CC=C(Cl)C=C4)NC([[email protected]@H](CC5=CC=C6C=CC=CC6=C5)NC(C)=O)=O)=O)=O)=O)C)=O)=O)=O)=O)CCC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (67.75 mM)

H2O : 25 mg/mL (16.94 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6775 mL 3.3873 mL 6.7745 mL
5 mM 0.1355 mL 0.6775 mL 1.3549 mL
10 mM 0.0677 mL 0.3387 mL 0.6775 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.69 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.69 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AbarelixPPI 149R 3827PPI149PPI-149R3827R-3827GNRH ReceptorGonadotropin releasing hormone receptorGNRHRInhibitorinhibitorinhibit

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Product name:
Abarelix Acetate
Cat. No.:
HY-13534A
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