AChE/BChE-IN-41
AChE/BChE-IN-41 is an AChE and BChE inhibitor, with IC50 values of 64.58 nM and 35.19 nM, respectively. AChE/BChE-IN-41 exhibits anticancer effects against breast cancer and colon cancer.
For research use only. We do not sell to patients.
- Formula: C23H25FN2O2
- Molecular Weight:380.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
AChE 64.58 nM (IC50) |
BChE 35.19 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | IC50 |
20.78 μM
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Cytotoxicity against human MDA-MB-231 cells assessed as viability reduction incubated 72 hrs by MTT assay.
Cytotoxicity against human MDA-MB-231 cells assessed as viability reduction incubated 72 hrs by MTT assay.
|
42730239 |
| BT-20 | IC50 |
22.35 μM
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Cytotoxicity against human BT-20 cells assessed as viability reduction incubated 72 hrs by MTT assay.
Cytotoxicity against human BT-20 cells assessed as viability reduction incubated 72 hrs by MTT assay.
|
42730239 |
| HT-29 | IC50 |
10.37 μM
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Cytotoxicity against human HT-29 cells assessed as viability reduction incubated 72 hrs by MTT assay.
Cytotoxicity against human HT-29 cells assessed as viability reduction incubated 72 hrs by MTT assay.
|
42730239 |
| MCF7 | IC50 |
29.34 μM
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Cytotoxicity against human MCF-7 cells assessed as viability reduction incubated 72 hrs by MTT assay.
Cytotoxicity against human MCF-7 cells assessed as viability reduction incubated 72 hrs by MTT assay.
|
42730239 |
| BT-549 | IC50 |
14.92 μM
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Cytotoxicity against human BT-549 cells assessed as viability reduction incubated 72 hrs by MTT assay.
Cytotoxicity against human BT-549 cells assessed as viability reduction incubated 72 hrs by MTT assay.
|
42730239 |
In Vitro
AChE/BChE-IN-41 (up to 100 μM; 72 h) exhibits cytotoxicity against MDA-MB-231, BT-20, HT-29, MCF-7, and BT-549 cells, with IC50 values of 20.78, 22.35, 10.37, 29.34, and 14.92 μM, respectively[1].
AChE/BChE-IN-41 (Compound ECK) (10-30 μg/mL; 20 min) inhibits AChE and BChE, with IC50 values of 64.58 nM and 35.19 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231, BT-20, BT-549 (TNBC), MCF-7 (ER+), and HT-29 (colon cancer)
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Concentration:up to 100 μM
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Incubation Time:72 h
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Result:IC50 values were 20.78 μM for MDA-MB-231, 22.35 μM for BT-20, 10.37 μM for HT-29, 29.34 μM for MCF-7, and 14.92 μM for BT-549.
Chemical Information
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Molecular Weight 380.46
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Formula C23H25FN2O2
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SMILES
CCC1=CC=CC2=C1NC3=C2CCOC3(CC)CC(NC4=CC=C(F)C=C4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE/BChE-IN-41 Related Classifications
HY-189803 Related Classifications
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