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Cat. No.: HY-189408

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AChE/BChE-IN-43

BChE-IN-54 is a dual AChE/BChE inhibitor (Electrophorus electricus AChE (K_i = 29.05 nM) and equine serum BChE (K_i = 28.68 nM)). BChE-IN-54 can be used in the research of Alzheimer's disease.

For research use only. We do not sell to patients.

Formula: C₃₁H₂₇F₃N₄O₄
Molecular Weight:576.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AChE/BChE-IN-43 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

electric eel AChE

29.05 nM (Ki)

equine serum BChE

28.68 nM (Ki)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	IC50	41.53 μM	Cytotoxicity against human neuroblastoma SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by crystal violet staining method. Cytotoxicity against human neuroblastoma SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by crystal violet staining method.	42585890

In Vitro

BChE-IN-54 (Compound 6) (3.125-200 μM; 24 h) exhibits low cytotoxicity against SH-SY5Y neuronal cells with an IC₅₀ of 41.53 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 576.57
Formula C₃₁H₂₇F₃N₄O₄
SMILES

COC1=CC(/C=N/NC(C2=CC=C(C=C2)OC3=NC=CC=C3C(F)(F)F)=O)=CC(CN4CC5=C(C=CC=C5)CC4)=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Şenol H, et al. Development of novel diaryl ether-phenolic Mannich Base derivatives with potent cholinesterase inhibition and low neuronal toxicity. Bioorganic chemistry. 2026 Oct 05;181:110354.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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